Results 111 to 120 of about 632 (142)

Dose-dependent tissue tropism and efficacy of early BKI-1748 treatment in chronic <i>Toxoplasma gondii</i> infection in sheep. [PDF]

Food Waterborne Parasitol
Sánchez-Sánchez R, Calero-Bernal R, Velasco-Jiménez N, Gallego-Moreno I, Pérez-Díaz C, Bustamante R, Choi R, Hulverson MA, Hemphill A, Van Voorhis WC, Ortega-Mora LM.   +10 more
europepmc   +1 more source

Innovative prevention and control of coccidiosis: targeting sporogony for new control agent development. [PDF]

Poult Sci
Zhao D, Suo J, Liang L, Liang R, Zhou R, Ding J, Liu X, Suo X, Zhang S, Tang X.   +9 more
europepmc   +1 more source

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Pharmacokinetics of toltrazuril and its metabolite, toltrazuril sulfone, in suckling piglets following oral and intramuscular administrations

Journal of Veterinary Pharmacology and Therapeutics, 2023
AbstractToltrazuril (TZR) is currently the only registered chemotherapeutic drug in the European Union for the treatment of Cystoisospora suis. This study investigated the comparative pharmacokinetics and tissue concentration‐time profiles of TZR and its active metabolite, toltrazuril sulfone (TZR‐SO2), after oral (per os, p.o.) and intramuscular (i.m.)
Ta‐Wei Yeh, Tirawat Rairat, Chao‐Ming Wang, Ching‐Fen Wu, Szu‐Wei Huang, Chi‐Chung Chou, Hung‐Chih Kuo   +6 more
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Plasma disposition of toltrazuril and its metabolites, toltrazuril sulfoxide and toltrazuril sulfone, in rabbits after oral administration

Veterinary Parasitology, 2010
The objective of this study was to evaluate the pharmacokinetic profiles of toltrazuril (TZR), and its major metabolites toltrazuril sulfoxide (TZR x SO) and toltrazuril sulfone (TZR x SO(2)) in rabbits after oral administrations. Rabbits were dosed once with 10 and 20mg/kg TZR via stomach tube with manual restraint.
Myoung-Seok, Kim, Jong-Hwan, Lim, Youn-Hwan, Hwang, Byung-Kwon, Park, In-Bae, Song, Hyo-In, Yun   +5 more
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ACUTE TOXICITY STUDY BASED ON TOLTRAZURIL, TINIDAZOLE AND LEVAMISOLA

International Journal of Veterinary Medicine, 2022
As a result of the studies, it was found that the proposed drug based on toltrazuril, tinidazole and levamisole hydrochloride according to the average lethal oral dose in accordance with GOST 12.1.007–76 belongs to the fourth hazard class - low-hazard substances.
A. V. Butenko, V. A. Orobec, I. V. Kireev   +2 more
openaire   +1 more source

Experimental Treatment of Hepatozoon Infections with the Anticoccidial Agent Toltrazuril

Journal of Veterinary Medicine, Series B, 1988
SummaryA new in vivo test model for experimental anticoccidial drug research has been developed. Hepatozoon erhardovae, a very common flea‐borne hemogregarine species of the European bank vole, causes lethal infections when sufficient sporozoites are administered.
H E, Krampitz, A, Haberkorn
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Screening of Additives for Preparing 5% Toltrazuril Suspension Concentrate

Advanced Materials Research, 2013
Suitable additives are the essential parts of 5% toltrazuril suspension concentrate. This paper mainly focused on screening additives for preparing 5% toltrazuril suspension concentrate. Results show that xanthan gum is a suitable suspending agent, 1,2-propanediol is optimal wetting agent, and citric acid act excellently as flocculant.
Zhi Hui Hao, Ke Feng Xiao, Lei Lei Wang
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Immunity to coccidiosis after treatment with toltrazuril

Parasitology Research, 2000
Some characteristics of immune sera after toltrazuril treatment which may be involved in the enhancement of immunity are as follows. Firstly, toltrazuril acts against all intracellular parasite stages from 1 to 168 h post-infection: intracellular schizonts of generations I, II and III and also intracellular gamonts.
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Migration and toxicity of toltrazuril and its main metabolites in the environment

Chemosphere, 2022
Veterinary drugs heavily used in livestock are passed into the environment through different ways, resulting in risks to terrestrial environments and humans. The migration of toltrazuril (TOL), an important anticoccidial drug used intensively in livestock, and its main metabolites between the chicken manure compost, soil and vegetables was investigated,
Meixia Huo, Wenjin Ma, Kaixiang Zhou, Xiangyue Xu, Zhenli Liu, Lingli Huang   +5 more
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Toltrazuril does not show an effect against pigeon protozoal encephalitis

Parasitology Research, 2015
The protozoan parasite Sarcocystis calchasi causes a severe neurologic disease in domestic pigeons (Columba livia f. dom.) named pigeon protozoal encephalitis. Recently, the parasite has also been reported in psittacines causing a virtually identical disease with fatal outcome. So far, an etiological treatment of S.
Kristina, Maier, P, Olias, A D, Gruber, M, Lierz   +3 more
openaire   +2 more sources