Results 31 to 40 of about 7,203,845 (300)

Curvilinear tool path generation for pocket machining

open access: yes, 2011
In this paper, a curvilinear tool path generation method with implicit moving boundaries is presented for pocket machining. The pocket profile is implicitly embedded into a higher-dimensional function, namely the level set function, and is represented ...
Z-H Xiong, H Ding, C-G Zhuang
core   +1 more source

Automated tool-path generation for rapid manufacturing and numerical simulation of additive manufacturing LMD geometries

open access: yes, 2020
6 S.In additive manufacturing (AM) Laser Metal Deposition (LMD), parts are built by welding layers of powder feedstock onto a substrate. Applications for steel powders include forging tools and structural components for various industries.
Biegler, Max   +3 more
core   +1 more source

Structure‐forward targeting of claudins with synthetic binders

open access: yesFEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Path Planning Method for Wire-Based Additive Manufacturing Processes

open access: yesModelling
The relevance of creating specialized computer programs that convert a virtual 3D model of an object into machine code (G-code) for controlling the process of 3D printing products from wire raw materials is substantiated.
Alexey Shcherbakov   +5 more
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

open access: yesFEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee   +2 more
wiley   +1 more source

Process design and tool path generation for end milling considering tool life

open access: yesJournal of Advanced Mechanical Design, Systems, and Manufacturing
In mass production, the tool life of cutting tools is generally controlled by the number of parts to be machined and the machining time, making it difficult to operate each tool to its full life.
Rei MATSUMURA   +2 more
doaj   +1 more source

Comparative study on path interval determinations in filleted end milling

open access: yesEngineering and Applied Science Research, 2022
This study provides several findings obtained from the comparisons of path interval determinations in filleted end milling with a tool inclination. CNC milling machine is one of the core technologies in practical manufacturing.
Tsutomu Sekine, Kyoko Kameya
doaj  

Tool path generation for rough machining using STEP.

open access: yes, 1995
The production efficiency has been significantly improved over the years due to the rapid advancement in CAD and CAM. Very often, however, the production cycle is still unacceptably long. This has been frequently caused by the bottleneck link between CAD
Ahamed, Shafee.
core   +1 more source

Soft motions encoded by the fold and mediated by conserved hinge sites drive V‐ATPase allosteric machinery and autoinhibition

open access: yesFEBS Letters, EarlyView.
Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana   +3 more
wiley   +1 more source

Research and Application of CNC Machining Method Based on CAD/CAM/Robot Integration

open access: yesAdvances in Multimedia, 2022
In order to improve the effect of intelligent CNC machining, this paper combines the CAD/CAM/Robot integration method to improve the CNC machining method and analyzes the tool path planning method and the path generation algorithm of the five-axis CNC ...
Xiangsong Yan
doaj   +1 more source

Home - About - Disclaimer - Privacy