Results 51 to 60 of about 512,570 (308)

Research and Application of CNC Machining Method Based on CAD/CAM/Robot Integration

Advances in Multimedia, 2022
In order to improve the effect of intelligent CNC machining, this paper combines the CAD/CAM/Robot integration method to improve the CNC machining method and analyzes the tool path planning method and the path generation algorithm of the five-axis CNC ...
Xiangsong Yan
doaj   +1 more source

Investigation of Cutting Path Effect on Spindle Vibration and AE Signal Features for Tool Wear Monitoring in Micro Milling

Applied Sciences, 2023
In the development of a tool wear monitoring system in milling, the complex cutting path always brings challenges to the system’s reliability in the production line.
Ci-Rong Huang, Ming-Chyuan Lu
doaj   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

End-to-End Tool Path Generation for Triangular Mesh Surfaces in Five-Axis CNC Machining

AppliedMath
Triangular mesh surface representation is widely adopted in geometric design and reverse engineering applications. However, in high-precision Computer Numerical Control (CNC) machining, significant limitations persist in automated Computer-Aided ...
Shi-Chu Li, Hong-Yu Ma, Bo-Wen Zhang, Li-Yong Shen   +3 more
doaj   +1 more source

Tool-Path Problem in Direct Energy Deposition Metal-Additive Manufacturing: Sequence Strategy Generation

IEEE Access, 2020
The tool-path problem has been extensively studied in manufacturing technologies, as it has a considerable impact on production time. Additive manufacturing is one of these technologies; it takes time to fabricate parts, so the selection of optimal tool ...
Maialen Murua, Alfredo Suarez, Diego Galar, Roberto Santana   +3 more
doaj   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

Optimal Joint Path Planning of a New Virtual-Linkage-Based Redundant Finishing Stage for Additive-Finishing Integrated Manufacturing

Mathematics, 2023
This paper describes the optimal path planning of a redundant finishing mechanism developed for joint space-based additive-finishing integrated manufacturing (AFM). The research motivation results from an inevitable one-sided layout of a finishing stage (
Jiwon Yu, Haneul Jeon, Hyungjin Jeong, Donghun Lee   +3 more
doaj   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Intelligent process planning and control of DED (directed energy deposition) for rapid manufacturing

Journal of Advanced Mechanical Design, Systems, and Manufacturing, 2020
This research has been conducted to develop computer aided manufacturing software, which can generate NC programs for a five-axis directed energy deposition (DED) type additive manufacturing system with following three focuses: 1.
Masahiro UEDA, David CARTER, Kazuo YAMAZAKI, Yasuhiro KAKINUMA   +3 more
doaj   +1 more source