Results 41 to 50 of about 90,035 (265)

Evolutionary algorithms for generation and optimization of tool paths [PDF]

CIRP Annals, 2015
Abstract The efficiency of many manufacturing processes is dependent on the properties of the motion path that an end-effector or cutting tool follows. Consequently, algorithms have been developed for generating such tool paths with the aim of optimizing various objectives.
Aydin Nassehi, Wesley Essink, Jack Barclay   +2 more
openaire   +2 more sources

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

Path Planning Method for Wire-Based Additive Manufacturing Processes

Modelling
The relevance of creating specialized computer programs that convert a virtual 3D model of an object into machine code (G-code) for controlling the process of 3D printing products from wire raw materials is substantiated.
Alexey Shcherbakov, Alexander Gudenko, Andrey Sliva, Daria Gaponova, Artem Marchenkov, Alexey Goncharov   +5 more
doaj   +1 more source

Development of a New Computer Aided Manufacturing System for Variable Pitch Screws Fabrication [PDF]

한국정밀공학회지, 2020
The study focused on the development of the CAM system restricted to the fabrication of variable pitch screws by using turning centers. To develop the dedicated CAM system at a low cost, open source programming language was used as much as possible.
Yuta Nabeta, Samyak Jain, Anthony Beaucamp, Yoshimi Takeuchi   +3 more
doaj   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Process design and tool path generation for end milling considering tool life

Journal of Advanced Mechanical Design, Systems, and Manufacturing
In mass production, the tool life of cutting tools is generally controlled by the number of parts to be machined and the machining time, making it difficult to operate each tool to its full life.
Rei MATSUMURA, Isamu NISHIDA, Keiichi SHIRASE   +2 more
doaj   +1 more source

Comparative study on path interval determinations in filleted end milling

Engineering and Applied Science Research, 2022
This study provides several findings obtained from the comparisons of path interval determinations in filleted end milling with a tool inclination. CNC milling machine is one of the core technologies in practical manufacturing.
Tsutomu Sekine, Kyoko Kameya
doaj  

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Why human connection is the true metric of research success

FEBS Open Bio, EarlyView.
Human‐centred mentorship can be shaped by mentor attributes, actions, intrinsic drive and career ambition. Drawing on reflections across Singapore and France, as well as workshop insights from FEBS‐IUBMB ENABLE 2024, this article shows that human‐centred mentorship creates the conditions for sustainable growth, well‐being and retention in research ...
Timothy Lin Yun Tan, Mattias Wei Ren Kon, Xavier Coumoul, Fun Man Fung   +3 more
wiley   +1 more source