Results 41 to 50 of about 512,570 (308)

Improving Energy Transition Analysis Tool through Hydropower Statistical Modelling

Energies, 2020
Reservoir and pumped hydro storage facilities represent one of the best options for providing flexibility at low marginal cost and very low life cycle carbon emissions.
Cristobal Gallego-Castillo, Marta Victoria   +1 more
doaj   +1 more source

Guidelines for Pediatric Radiotherapy Simulation: A Report From the Children's Oncology Group Radiation Oncology Discipline

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Pediatric radiation therapy presents unique challenges compared to adult treatments, including those of immobilization, potential need for sedation, and the critical importance of accurate, reproducible positioning. Additionally, heightened attention to imaging doses is necessary to minimize long‐term toxicity in survivors.
Parham Alaei, Stephen Mihalcik, Sujith Baliga, Young Kwok, Dana Casey, Eric Ehler, Christiane Burton, John C. Breneman, Daphne A. Haas‐Kogan, Suzanne L. Wolden, Arnold C. Paulino, Nadia N. Laack, Natia Esiashvili, Sarah Milgrom, Christine Hill‐Kayser, Thomas J. Fitzgerald, John A. Kalapurakal, Chia‐Ho Hua   +17 more
wiley   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Path Planning Method for Wire-Based Additive Manufacturing Processes

Modelling
The relevance of creating specialized computer programs that convert a virtual 3D model of an object into machine code (G-code) for controlling the process of 3D printing products from wire raw materials is substantiated.
Alexey Shcherbakov, Alexander Gudenko, Andrey Sliva, Daria Gaponova, Artem Marchenkov, Alexey Goncharov   +5 more
doaj   +1 more source

Development of a New Computer Aided Manufacturing System for Variable Pitch Screws Fabrication [PDF]

한국정밀공학회지, 2020
The study focused on the development of the CAM system restricted to the fabrication of variable pitch screws by using turning centers. To develop the dedicated CAM system at a low cost, open source programming language was used as much as possible.
Yuta Nabeta, Samyak Jain, Anthony Beaucamp, Yoshimi Takeuchi   +3 more
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Process design and tool path generation for end milling considering tool life

Journal of Advanced Mechanical Design, Systems, and Manufacturing
In mass production, the tool life of cutting tools is generally controlled by the number of parts to be machined and the machining time, making it difficult to operate each tool to its full life.
Rei MATSUMURA, Isamu NISHIDA, Keiichi SHIRASE   +2 more
doaj   +1 more source

Comparative study on path interval determinations in filleted end milling

Engineering and Applied Science Research, 2022
This study provides several findings obtained from the comparisons of path interval determinations in filleted end milling with a tool inclination. CNC milling machine is one of the core technologies in practical manufacturing.
Tsutomu Sekine, Kyoko Kameya
doaj  

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source