Results 101 to 110 of about 9,334,973 (302)
Study of the cosmic ray primary composition at E0 ~ 1000 TeV by EAS-TOP and MACRO at Gran Sasso
, 1994 An analysis of the coincident deep underground muon data and of the e.m. component of Extensive Air Showers (EAS) as measured by the MACRO and EAS-TOP experiments at Gran Sasso is presented. Constraints on the primary cosmic ray composition are obtained,
BARBARINO, GIANCARLO +3 more
core +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
IO-Top-k: Index-access Optimized Top-k Query Processing.
, 2006 Top-k query processing is an important building block for ranked retrieval, with applications ranging from text and data integration to distributed aggregation of network logs and sensor data. Top-k queries operate on index lists for a query's elementary conditions and aggregate scores for result candidates.
Hannah Bast +4 more
openaire +3 more sources
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Efficient Top-k Spatial Dataset Search Processing
Applied SciencesIn this paper, we introduce two novel top-k spatial dataset search schemes, KSDS and KSDS+. The core innovation of these schemes lies in partitioning the spatial datasets into grids and assessing similarity based on the distribution of points within ...
Jie Sun +6 more
doaj +1 more source
Top-k SAS : on reliable retrieval of top-k tags
, 2020 above method is quite challenging. To address this problem, we propose a learning-based method which applies machine learning models to estimate whether the k most frequent tags are qualified to be the top-k tags. Experiment on the same datasets demonstrate that the learning-based method achieves comparable performance while overcoming the difficulty of ...
openaire +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Efficient Authentication of Multi-Dimensional Top-
IEEE Access, 2019 With the increasing popularity of cloud computing, query outsourcing services are becoming widely available for many business applications. However, the third-party cloud server which provides query service is untrusted, and thus the correctness of query
Xiaoyu Zhu +4 more
doaj +1 more source
Top-k Spatio-Textual Similarity Join
, 2016 With the development of location-based services (LBS), LBS users are generating more and more spatio-textual data, e.g., checkins and attraction reviews.
Zhiguo Gong (20046153) +6 more
core
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source