Results 31 to 40 of about 2,055 (160)

Tophaceous gout presented as a posterior cruciate ligament mass and addressed by posterior knee arthroscopy: A case report and literature review

Journal of Orthopaedic Reports
Background: Tophaceous gout, when manifested as a posterior cruciate ligament (PCL) mass within a joint, is uncommon. Differentiating it from other intraarticular pathologies, notably tenosynovial giant cell tumors (TGCT), previously known as pigmented ...
Osama Alzobi, Ayyoub Mohammed, Ashraf Hantouly, Ghislain Aminake, Theodorakys Marín, Bashir Zikria   +5 more
doaj   +1 more source

Tocilizumab improved clinical symptoms of a patient with systemic tophaceous gout who had symmetric polyarthritis and fever: An alternative treatment by blockade of interleukin-6 signaling

SAGE Open Medical Case Reports, 2014
Chronic tophaceous gout is the end stage of gout. We employed a blockade of interleukin-6 signaling therapy by tocilizumab instead of anakinra, an interleukin-1 receptor antagonist, for a 61-year-old Japanese woman diagnosed with tophaceous gout ...
Sho Mokuda, Masamoto Kanno, Kiyoshi Takasugi, Chikara Okumura, Yuki Ito, Junya Masumoto   +5 more
doaj   +1 more source

Actovegin administration in patients with ulcerated gout tophuses

Научно-практическая ревматология, 2005
Objective. To study actovegin efficacy in the treatment of chronic skin ulcers due to ulceration of tophuses in pts with chronic tophaceous gout. Materials and methods.
M S Eliseev, V G Barskova
doaj   +1 more source

TOPHACEOUS GOUT OF THE AXIAL SKELETON [PDF]

Australian and New Zealand Journal of Medicine, 1988
Abstract:A 72‐year‐old female with a recent episode of podagra, without peripheral tophi, presented with nocturnal back pain and a destructive lesion of the right lamina of L4. A tophus was excised at laminectomy. Evidence of an axial skeletal tophus causing an irritative radiculopathy via mass effect is presented.
Arnold, M. H., Savvas, P., Brooks, P. M., Ruff, S.   +3 more
openaire   +5 more sources

A Return to Normality: A Descriptive Qualitative Interview Study Exploring the Patient Experience of Gout Flare Resolution

Arthritis Care &Research, EarlyView.
Objective Although the definition of a gout flare is well established, the state of gout flare resolution has not yet been defined. This study aimed to explore patients’ experiences and perceptions of gout flare resolution. Methods Semistructured interviews were conducted with 24 people with gout, guided by open‐ended questions exploring their ...
Sarah Stewart, Anne Horne, Angelo Gaffo, Lisa K. Stamp, N. Lawrence Edwards, Nicola Dalbeth   +5 more
wiley   +1 more source

Chronic tophaceous gout with unusual large tophi: case report

The Pan African Medical Journal, 2015
Gout is a metabolic disease, which is characterized by acute or chronic arthritis, and deposition of monosodium urate crystals in joint, bones, soft tissues, and kidneys. But large tophi are unsual in chronic gout.
Nassira Aradoini, Sofia Talbi, Khadija Berrada, Fatima Zahra Abourazzak, Taoufik Harzy   +4 more
doaj   +1 more source

Identification of an Osteochondral Erosion Process in Gout Driven by Fibrinogen‐Integrin Activation and Local MSU Crystallization

Advanced Science, EarlyView.
Cartilage injury promotes local fibrinogen deposition, which accelerates monosodium urate crystallization and activates integrin‐mediated matrix‐degradation. This self‐amplifying cycle drives gout‐related cartilage erosion. Disrupting fibrinogen deposition or restoring the cartilage barrier could interrupt this vicious cycle.
Hanlin Xu, Simin Bi, Zhechen Liu, Xiaofeng Zhou, Hengwei Qin, Nicola Dalbeth, Minbiao Ji, Yinghui Hua   +7 more
wiley   +1 more source

Efficacy and Safety of Nanoencapsulated Sirolimus Plus Pegadricase: Results From the Randomized, Placebo‐Controlled Phase 3 Trials

Arthritis &Rheumatology, EarlyView.
Objective DISSOLVE I and II examined the efficacy and safety of nanoencapsulated sirolimus (NAS) plus pegadricase (NASP) in patients with uncontrolled gout (UG). Methods In these double‐blind, placebo‐controlled Phase 3 trials of NASP, patients were randomized 1:1:1 to infusions of high‐dose (HD) or low‐dose (LD) NAS plus pegadricase (HD NASP, LD NASP,
Herbert S. B. Baraf, Puja P. Khanna, Milan Petronijevic, Mamuka Lortkipanidze, Anand Patel, Kwabena Ayesu, Michael H. Pillinger, Atul Singhal, Joanna Sobierska, Jacquie Christie, Peter Traber, Rehan Azeem, Wesley DeHaan, Hugues Santin‐Janin, Bhavisha Desai, Alan Kivitz   +15 more
wiley   +1 more source

When Joint Aspiration Fails: Point‐of‐Care Ultrasound for Diagnosing Chronic Gout in Prolonged Monoarthritis

Journal of General and Family Medicine, Volume 27, Issue 5, September 2026.
ABSTRACT Background A 34‐year‐old man presented to our primary care clinic with persistent pain and swelling of the right first metatarsophalangeal joint lasting 3 months. A previous clinic had suspected gout based on hyperuricemia, but urate‐lowering therapy was repeatedly withheld because of ongoing inflammation, resulting in prolonged symptoms ...
Takayuki Yamada
wiley   +1 more source

Massive laryngeal gouty tophus: A case report and comprehensive literature review

Otolaryngology Case Reports
Laryngeal gout is an uncommon manifestation of chronic tophaceous crystal deposition. This report presents a case of a midline neck mass associated with gout affecting the thyroid cartilage.
Qi Fu, Yixin Jing, Weiming Liu, Lei Liu, Hongbo Xu   +4 more
doaj   +1 more source