Results 101 to 110 of about 1,485,493 (255)
FEBS Letters, EarlyView.CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens +8 more
wiley +1 more source
Information structure and its syntactic manifestation in Spanish: facts and proposals
Borealis: An International Journal of Hispanic Linguistics, 2016 This article presents the main facts about how information structure is syntactically codified in Spanish, with particular attention to the syntax of topics and foci.
Antonio Fábregas
doaj +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Topicalization in Japanese Cooking Discourse
Open Linguistics, 2019 A topic-wa-phrase is analyzed here in written recipes and the corresponding spoken instructional cooking discourse. Despite the possible assumption that the topic phrase is not used in recipes, the analysis shows that ingredients of a recipe are ...
Shimojo Mitsuaki
doaj +1 more source
Information-Seeking Chat: Dialogues Driven by Topic-Structure [PDF]
, 2004 Stede M, Schlangen D. Information-Seeking Chat: Dialogues Driven by Topic-Structure. In: Vallduv'ı E, ed. Proceedings of Catalog (the 8th workshop on the semantics and pragmatics of dialogue; SemDial04).
Schlangen, David ; https://orcid.org/ +2 more
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Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Utterances as tool-mediated specifications of affordances - ecological pragmatics
Psychology of Language and Communication, 2018 The established descriptions of information structure assume that the basic cognitive unit is a categorization, and that the basic semantic structure is a predication.
Borchmann Simon
doaj +1 more source
FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source
Human-competitive automatic topic indexing [PDF]
, 2009 Topic indexing is the task of identifying the main topics covered by a document. These are useful for many purposes: as subject headings in libraries, as keywords in academic publications and as tags on the web.
Medelyan, Olena
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