Results 101 to 110 of about 1,611,945 (272)

Integrating Document Clustering and Topic Modeling [PDF]

arXiv, 2013
Document clustering and topic modeling are two closely related tasks which can mutually benefit each other. Topic modeling can project documents into a topic space which facilitates effective document clustering. Cluster labels discovered by document clustering can be incorporated into topic models to extract local topics specific to each cluster and ...
arxiv  

Integration of single‐cell and bulk RNA‐sequencing data reveals the prognostic potential of epithelial gene markers for prostate cancer

Molecular Oncology, EarlyView.
Prostate cancer is a leading malignancy with significant clinical heterogeneity in men. An 11‐gene signature derived from dysregulated epithelial cell markers effectively predicted biochemical recurrence‐free survival in patients who underwent radical surgery or radiotherapy.
Zhuofan Mou, Lorna W. Harries
wiley   +1 more source

Lifelong Neural Topic Learning in Contextualized Autoregressive Topic Models of Language via Informative Transfers [PDF]

arXiv, 2019
Topic models such as LDA, DocNADE, iDocNADEe have been popular in document analysis. However, the traditional topic models have several limitations including: (1) Bag-of-words (BoW) assumption, where they ignore word ordering, (2) Data sparsity, where the application of topic models is challenging due to limited word co-occurrences, leading to ...
arxiv  

Etoposide‐induced cancer cell death: roles of mitochondrial VDAC1 and calpain, and resistance mechanisms

Molecular Oncology, EarlyView.
The complex mode of action of the topoisomerase II inhibitor etoposide in triggering apoptosis involves several mechanisms: overexpression of the mitochondrial protein VDAC1, leading to its oligomerization and formation of a large channel that mediates the release of pro‐apoptotic protein; and overexpression of the apoptosis regulators p53, Bax, and ...
Aditya Karunanithi Nivedita, Varda Shoshan‐Barmatz   +1 more
wiley   +1 more source

Topic analysis using a finite mixture model [PDF]

, 2000
Hang Li, Kenji Yamanishi
openalex   +1 more source

Using an explicit query and a topic model for scientific article recommendation. [PDF]

Educ Inf Technol (Dordr), 2023
Smail B, Aliane H, Abdeldjalil O.
europepmc   +1 more source

Respiratory complex I‐mediated NAD+ regeneration regulates cancer cell proliferation through the transcriptional and translational control of p21Cip1 expression by SIRT3 and SIRT7

Molecular Oncology, EarlyView.
NAD+ regeneration by mitochondrial complex I NADH dehydrogenase is important for cancer cell proliferation. Specifically, NAD+ is necessary for the activities of NAD+‐dependent deacetylases SIRT3 and SIRT7, which suppress the expression of p21Cip1 cyclin‐dependent kinase inhibitor, an antiproliferative molecule, at the translational and transcriptional
Masato Higurashi, Kazunori Mori, Hidetsugu Nakagawa, Momoko Uchida, Fumihiro Ishikawa, Motoko Shibanuma   +5 more
wiley   +1 more source

Empirical Comparison of Word Similarity Measures Based on Co-Occurrence, Context, and a Vector Space Model

Journal of Information Science Theory and Practice, 2020
Word similarity is often measured to enhance system performance in the information retrieval field and other related areas. This paper reports on an experimental comparison of values for word similarity measures that were computed based on 50 ...
Natsuki Kadowaki, Kazuaki Kishida
doaj   +1 more source

Quality indices for topic model selection and evaluation: a literature review and case study. [PDF]

BMC Med Inform Decis Mak, 2023
Meaney C, Stukel TA, Austin PC, Moineddin R, Greiver M, Escobar M.   +5 more
europepmc   +1 more source

Response to neoadjuvant chemotherapy in early breast cancers is associated with epithelial–mesenchymal transition and tumor‐infiltrating lymphocytes

Molecular Oncology, EarlyView.
Epithelial–mesenchymal transition (EMT) and tumor‐infiltrating lymphocytes (TILs) are associated with early breast cancer response to neoadjuvant chemotherapy (NAC). This study evaluated EMT and TIL shifts, with immunofluorescence and RNA sequencing, at diagnosis and in residual tumors as potential biomarkers associated with treatment response.
Françoise Derouane, Jérôme Ambroise, Cédric van Marcke, Mieke Van Bockstal, Martine Berlière, Christine Galant, Hélène Dano, Médina Lougué, Elena Benidovskaya, Guy Jerusalem, Vincent Bours, Claire Josse, Jérôme Thiry, Aurélie Daumerie, Caroline Bouzin, Cyril Corbet, François P. Duhoux   +16 more
wiley   +1 more source