Results 41 to 50 of about 2,655,093 (273)

Topical Administration of SLN-Based Gene Therapy for the Treatment of Corneal Inflammation by De Novo IL-10 Production

open access: yesPharmaceutics, 2020
One of the main challenges in gene therapy is the issue of delivery, and it is especially relevant for the success of gene therapy in the cornea. In the present work, eye drops containing biocompatible non-viral vectors based on solid lipid nanoparticles
Mónica Vicente-Pascual   +7 more
semanticscholar   +1 more source

Steroid induced osteonecrosis: An analysis of steroid dosing risk. [PDF]

open access: yes, 2010
Osteonecrosis is a serious condition involving bone destruction that frequently requires surgical treatment to rebuild the joint. While there is an abundance of literature documenting corticosteroid related osteonecrosis, there is no consensus as to the ...
Chang, Christopher   +4 more
core   +1 more source

Tear Film Pharmacokinetics and Systemic Absorption Following Topical Administration of 1% Prednisolone Acetate Ophthalmic Suspension in Dogs

open access: yesFrontiers in Veterinary Science, 2020
The study aimed to determine the tear film pharmacokinetics following topical administration of 1% prednisolone acetate—assessing whether two drops would provide a superior kinetic profile compared to one drop—and to determine the fraction of an eye drop
L. Sebbag   +3 more
semanticscholar   +1 more source

A Novel Model of Pain Sensation Using Superfused Gastrosplenic Omentum Preparation of Anesthetized Rats

open access: yesJournal of Pharmacological Sciences, 2008
A pain model for screening analgesics was established in anesthetized rats. The omenta of urethane-anesthetized rats were exteriorized, fixed in a plastic chamber, and superfused with Tyrode solution.
Shi-Jie Yang   +2 more
doaj   +1 more source

New patents on topical anesthetics. [PDF]

open access: yes, 2014
Anesthesia is defined as a total or partial loss of sensation and it may be general, local or topical, depending on the method of drug administration and area of the body affected.
CALVIERI, Stefano   +6 more
core   +1 more source

Novel locally active estrogens accelerate cutaneous wound healing-part 2 [PDF]

open access: yes, 2017
Estrogen deprivation is associated with delayed healing, while estrogen replacement therapy (ERT) accelerates acute wound healing and protects against development of chronic wounds.
Bartoli, Gabriele   +12 more
core   +2 more sources

Ice versus lidocaine 5% gel for topical anaesthesia of oral mucosa – a randomized cross-over study

open access: yesBMC Anesthesiology, 2019
Background Topical anaesthesia is important to optimize pain control during dental injection. Our aim was to describe a new simple method for topical anaesthesia of oral mucosa and to compare the effectiveness of ice and lidocaine 5% gel for topical ...
Nishma Hindocha   +3 more
doaj   +1 more source

Plasma pharmacokinetics of tigolaner, emodepside, and praziquantel following topical administration of a combination product (Felpreva®) and of intravenous administration of the individual active ingredients in cats

open access: yesCurrent Research in Parasitology and Vector-Borne Diseases, 2023
Felpreva® for cats contains the new acaricidal/insecticidal active ingredient tigolaner in a fixed combination with the nematocidal and cestocidal compounds emodepside and praziquantel, respectively.
Norbert Mencke   +5 more
doaj   +1 more source

Fungicidal activity plus reservoir effect allow short treatment courses with terbinafine in tinea pedis [PDF]

open access: yes, 2008
Terbinafine, a synthetic allylamine, exerts fungicidal activity against dermatophytes, the causative pathogens of tinea pedis. As proven in numerous clinical trials, tinea pedis can be effectively and safely treated by topical terbinafine.
Korting, Hans Christian   +2 more
core   +1 more source

Corneal Infection Therapy with Topical Bacteriophage Administration [PDF]

open access: yesThe Open Ophthalmology Journal, 2015
Staphylococcus aureus is a major pathogen in bacterial keratitis, a vision-threatening disease. Although the incidence of S. aureus keratitis varies worldwide, the increasing trend of resistance to certain antibiotics makes this condition an important, global, healthcare concern.
Fadlallah, Ali   +2 more
openaire   +2 more sources

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