Results 81 to 90 of about 28,018 (262)
Efikasi dan Toleransi Monoterapi Topiramate pada Epilepsi
Sari Pediatri, 2016 Latar belakang. Epilepsi merupakan masalah besar dalam bidang pediatri, masih terdapat 10%-15% pasien yang resisten terhadap pengobatan. Topiramate sebagai obat antiepilepsi baru mempunyai spektrum luas untuk anti kejang.
Prastiya Indra Gunawan
doaj +1 more source
The efficacy of topiramate in alcohol dependence therapy – current research and prospects of use
, 2017 Alcohol dependence (AD) is a chronic and recurrent disease that is a major social and clinical problem. The Food and Drug Administration (FDA) has approved a few drugs for AD treatment like disulfiram, naltrexone and acamprosate.
Ewa Zwierzyńska +2 more
core +1 more source
Epilepsia, EarlyView.Abstract Objective To describe treatment decisions after first anti‐seizure medication (ASM) failure in focal epilepsy and describe how they have changed across two trial eras, and whether observed prescribing matched clinicians stated preferences. Methods We analyzed the focal epilepsy cohorts from two UK pragmatic, randomized trials, Standard and New
Isaac J. Egesa +4 more
wiley +1 more source
Inherited metabolic epilepsies–established diseases, new approaches
Epilepsia Open, EarlyView.Abstract Inherited metabolic epilepsies (IMEs) represent the inherited metabolic disorders (IMDs) in which epilepsy is a prevailing component, often determining other neurodevelopmental outcomes associated with the disorder. The different metabolic pathways affected by individual IMEs are the basis of their rarity and heterogeneity.
Itay Tokatly Latzer, Phillip L. Pearl
wiley +1 more source
Epileptic drop attacks: More than just atonic seizures
Epilepsia Open, EarlyView.Abstract “Drop attacks” are not officially defined by the International League Against Epilepsy. Seizures are characterized by a sudden loss of control over the trunk and posture, leading to falls and injuries, and resolving within a few seconds. Accurately diagnosing the type of seizure is usually difficult due to limitations in clinical documentation
Tomonori Ono +3 more
wiley +1 more source
Infantile Spasms Respond Poorly to Topiramate
, 2015 Introduction: Infantile spasms are seizures typical of an age-related epileptic encephalopathy. Although evidence supporting topiramate for infantile spasms is lacking, many clinicians use it for this indication.
Cole, Justin W. +2 more
core +1 more source
The multiple hit model of infantile and epileptic spasms: The 2025 update
Epilepsia Open, EarlyView.Abstract Objective Infantile and epileptic spasms syndrome (IESS) is a developmental and epileptic encephalopathy manifesting with epileptic spasms and poor neurodevelopmental outcomes. There is an urgent need for the development of more effective and tolerated therapies.
Aristea S. Galanopoulou +6 more
wiley +1 more source
Urolithiasis associated with topiramate
, 2017 OBJECTIVE: Topiramate is a sulfamate-substituted monosaccharide anticonvulsant used as adjunctive therapy for intractable refractory seizures. It is report a case of topiramate-induced urolithiasis.
Kim, Samuel C. +4 more
core
Topiramate in opiate withdrawal.
, 2002 The alpha2-adrenergic agonist clonidine is the mainly used drug for the opiate withdrawal. Its efficacy and tolerance in treating withdrawal symptoms is, however, suboptimal.
Zullino, D.F. +5 more
core +1 more source
Epilepsia Open, EarlyView.Abstract Drug‐resistant epilepsy (DRE) affects approximately one‐third of patients with epilepsy and represents a major unmet clinical need. While traditional hypotheses of pharmacoresistance have focused on alterations in drug targets, efflux transporter overexpression, and intrinsic disease severity, the gut microbiome has recently emerged as a ...
Khaled Zammar +4 more
wiley +1 more source