Results 91 to 100 of about 69,479 (251)

New biosensors and transgenic mice for multiplex cGMP imaging

British Journal of Pharmacology, EarlyView.
Background and Purpose Cyclic guanosine monophosphate (cGMP) is a versatile second messenger that is important for human (patho‐)physiology and pharmacotherapy. Live‐cell imaging of cGMP with biosensors allows to elucidate its spatiotemporal dynamics in real time under close‐to‐native conditions. However, to monitor two separate cGMP pools or cGMP/cAMP
Markus Wolters, Martin Thunemann, Barbara Birk, Susanne Feil, Viacheslav O. Nikolaev, Moritz Lehners, Robert Feil   +6 more
wiley   +1 more source

Instrumentos que avaliam a mobilidade de crianças e adolescentes com transtorno do espectro autista: Uma revisão sistemática e mapa de decisão

Developmental Medicine &Child Neurology, EarlyView.
Objetivos Identificar os instrumentos padronizados usados para avaliar aspectos de mobilidade em crianças e adolescentes com transtorno do espectro autista (TEA), analisar a qualidade de suas propriedades psicométricas e seu nível de evidência, e desenvolver um mapa de decisão clínica para esses instrumentos.
Arthur Felipe Barroso de Lima, Amanda Cristina Fernandes, Amanda Alves Rodrigues Soares, Hércules Ribeiro Leite, Ricardo Rodrigues de Sousa Junior   +4 more
wiley   +1 more source

Role-theoretic discourse analysis of German security policy: a case of German parliamentary debate on the mission in Afghanistan. [PDF]

Front Psychol, 2023
Ni X.
europepmc   +1 more source

Aristocratic identification in Felix’s Life of Guthlac

Early Medieval Europe, EarlyView.
Recent scholarship often sees high‐born monastics and clerics in early Christian England as part of the aristocratic class. Modern identity theories, however, suggest that social identity could be dynamic, situational, processual and discursive. In light of this concept, the present article reads Felix’s Life of Guthlac as a text that constructs an ...
Lek Hang Chan
wiley   +1 more source

Regulation of PHOX2B gene expression by the long non‐coding natural antisense RNA PHOX2B‐AS1

The FEBS Journal, EarlyView.
PHOX2B is a transcription factor essential for autonomic nervous system development. We identify and characterize PHOX2B‐AS1, a human long non‐coding antisense transcript at the PHOX2B locus, along with its murine counterpart. Our findings reveal bidirectional transcription and reciprocal regulation: PHOX2B activates PHOX2B‐AS1, whereas PHOX2B‐AS1 ...
Simona Di Lascio, Ana Lucia Cuadros Gamboa, Martina Bertocchi, Filippo Chiesa, Francesca Cargnin, Ettore Mosca, Paride Pelucchi, Viviana Tritto, Stefania Corti, Isabella Ceccherini, Paola Riva, Roberta Benfante, Diego Fornasari   +12 more
wiley   +1 more source

Physiologic and Transcriptomic Effects Triggered by Overexpression of Wild Type and Mutant DNA Topoisomerase I in Streptococcus pneumoniae. [PDF]

Int J Mol Sci, 2023
García-López M, Hernández P, Megias D, Ferrándiz MJ, Campa AG.   +4 more
europepmc   +1 more source

Anemia‐associated mutations disrupt the CDIN1‐Codanin1 complex in inherited congenital dyserythropoietic anemia I (CDA‐I) disease

The FEBS Journal, EarlyView.
Congenital dyserythropoietic anemia type I (CDA‐I) arises from mutations in Codanin1 and CDIN1. Using quantitative biophysical approaches, we show that disease‐associated mutations disrupt the CDIN1‐Codanin1 complex. Our findings provide critical insights into the molecular mechanism that links protein dysfunction to disturbing chromatin arrangement ...
Martin Stojaspal, Tomas Brom, Ivona Nečasová, Tomáš Janovič, Pavel Veverka, Naina Verma, Lukáš Uhrík, Lenka Hernychova, Ctirad Hofr   +8 more
wiley   +1 more source

The Incarnational Aesthetic of David Brown☆

International Journal of Systematic Theology, EarlyView.
Abstract The notion of incarnation has historically been a prominent concept for the acceptance of images and the interpretation of art within Christianity. A contemporary proponent of this line of reasoning about the theological potential of art is David Brown, who builds his theology of culture on the doctrine of incarnation. This article presents an
Filip Taufer
wiley   +1 more source

What Do Critics Owe the Romance? Keynote Address at the Second Annual Conference of the International Association for the Study of Popular Romance

Journal of Popular Romance Studies, 2011
A rhetorical analysis of criticism of popular romance fiction chosen from both the early, influential instances of such criticism as well as from more recent critical work reveals patterns of ethical lapses therein.
Pamela Regis
doaj  

Media’s role in the crisis: a discursive comparison of U.S. media representations of unemployment in 2008 and 2020

Frontiers in Communication
IntroductionThrough variations in reporting volume and discursive strategies, the media communicates risks to the public and shapes perceptions during crises.MethodsThis study conducted a corpus-based, quantitative analysis of topoi in American ...
Ling Yang, Lingli Yu
doaj   +1 more source