Results 231 to 240 of about 79,811 (267)
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Annual Review of Biochemistry, 1981
The various problems of disentangling DNA strands or duplexes in a cell are all rooted in the double-helical structure of DNA. Three distinct subfamilies of enzymes, known as the DNA topoisomerases, have evolved to solve these problems. This review focuses on work in the past decade on the mechanisms and cellular functions of these enzymes.
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The various problems of disentangling DNA strands or duplexes in a cell are all rooted in the double-helical structure of DNA. Three distinct subfamilies of enzymes, known as the DNA topoisomerases, have evolved to solve these problems. This review focuses on work in the past decade on the mechanisms and cellular functions of these enzymes.
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EcoSal Plus, 2015
DNA topoisomerases are enzymes that control the topology of DNA in all cells. There are two types, I and II, classified according to whether they make transient single- or double-stranded breaks in DNA. Their reactions generally involve the passage of a single- or double-strand segment of DNA through this transient break, stabilized by DNA-protein ...
Natassja G, Bush +2 more
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DNA topoisomerases are enzymes that control the topology of DNA in all cells. There are two types, I and II, classified according to whether they make transient single- or double-stranded breaks in DNA. Their reactions generally involve the passage of a single- or double-strand segment of DNA through this transient break, stabilized by DNA-protein ...
Natassja G, Bush +2 more
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Current Opinion in Cell Biology, 1990
DNA topoisomerases play an important role in regulating DNA structure, thus affecting many aspects of chromosome function inside cells. Recent progress in this field raises exciting questions regarding the distinct and critical functions of multiple topoisomerases, and the roles of DNA topoisomerases in the processes of chromosome condensation ...
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DNA topoisomerases play an important role in regulating DNA structure, thus affecting many aspects of chromosome function inside cells. Recent progress in this field raises exciting questions regarding the distinct and critical functions of multiple topoisomerases, and the roles of DNA topoisomerases in the processes of chromosome condensation ...
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Current Protocols in Pharmacology, 1998
AbstractTopoisomerases are nuclear enzymes that play essential roles in DNA replication, transcription, chromosome segregation, and recombination. All cells have two major forms of topoisomerases: the type I enzymes, which make single‐stranded cuts in DNA, and the type II enzymes, which cut and pass double‐stranded DNA.
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AbstractTopoisomerases are nuclear enzymes that play essential roles in DNA replication, transcription, chromosome segregation, and recombination. All cells have two major forms of topoisomerases: the type I enzymes, which make single‐stranded cuts in DNA, and the type II enzymes, which cut and pass double‐stranded DNA.
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2018
This chapter discusses single-molecule approaches in the study of topoisomerases. After introducing the problem posed by DNA entanglement, it describes type I and type II topoisomerases, which solve that issue. Single-molecule assays have nailed down the different mechanisms of bacterial and eukaryotic type I topoisomerases.
David Bensimon +4 more
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This chapter discusses single-molecule approaches in the study of topoisomerases. After introducing the problem posed by DNA entanglement, it describes type I and type II topoisomerases, which solve that issue. Single-molecule assays have nailed down the different mechanisms of bacterial and eukaryotic type I topoisomerases.
David Bensimon +4 more
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DNA sequence selectivity of topoisomerases and topoisomerase poisons
Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression, 1998Chemical agents able to interfere with DNA topoisomerases are widespread in nature, and some of them have clinical efficacy as antitumor or antibacterial drugs. Drugs which have as a target DNA topoisomerases could be divided into two categories: poisons and catalytic inhibitors.
G, Capranico, M, Binaschi
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Update on Cancer Therapeutics, 2003
Abstract This article reviews the mechanism of action, toxicity, pharmacology and clinical use of antineoplastic agents that inhibit the enzyme, topoisomerase II. Information presented in the medical and scientific literature in the past 3 years is especially highlighted.
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Abstract This article reviews the mechanism of action, toxicity, pharmacology and clinical use of antineoplastic agents that inhibit the enzyme, topoisomerase II. Information presented in the medical and scientific literature in the past 3 years is especially highlighted.
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DNA topoisomerases and topoisomerase inhibitors.
Pathologie-biologie, 1995DNA topoisomerases are ubiquitous nuclear enzymes, essential for several steps of DNA metabolism. They have recently been shown to be specific targets of a number of anticancer agents. In this review are discussed the most recent discoveries in the physiology and the molecular biology of DNA topoisomerases, and the mechanism of interaction with drugs ...
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Topoisomerases and Carcinogenesis: Topoisomerase IIIα and BLM
2011In human cells, Topoisomerase IIIα (Top3α) is the main partner of BLM, the Bloom syndrome (BS) helicase. BS constitutes a genetic and clinical model for recessive cancer predisposition and study of this disease may help to decipher pathways of carcinogenesis in the general population.
Mounira Amor-Guéret +1 more
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2005
Abstract Virtually every reaction that occurs in biological systems is catalysed by an enzyme. The interconversions of the different topological forms of DNA are no exceptions. The enzymes that catalyse these processes are known as DNA topoisomerases and constitute a widespread and fascinating group.
Andrew D Bates, Anthony Maxwell
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Abstract Virtually every reaction that occurs in biological systems is catalysed by an enzyme. The interconversions of the different topological forms of DNA are no exceptions. The enzymes that catalyse these processes are known as DNA topoisomerases and constitute a widespread and fascinating group.
Andrew D Bates, Anthony Maxwell
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