Results 251 to 260 of about 146,499 (323)

Therapeutic Strategies to Overcome Payload Resistance of Trastuzumab Deruxtecan in HER2‐Positive Cancers

Cancer Science, Volume 117, Issue 4, Page 996-1009, April 2026.
Overexpression of ABC transporters, especially ABCG2 and ABCB1, mediates acquired resistance to T‐DXd in HER2‐positive cancers. Inhibition of these transporters restored T‐DXd efficacy, highlighting efflux‐mediated resistance as a potential therapeutic target. ABSTRACT Antibody–drug conjugates (ADCs) are emerging as a promising class of targeted cancer
Yuya Murase, Shigeki Nanjo, Sachiko Arai, Sota Kondo, Hayato Koba, Yifeng Liu, Koji Fukuda, Shigeki Sato, Jun Kinoshita, Noriyuki Inaki, Tsukasa Ueda, Shunichi Nomura, Yuichi Tambo, Takahiro Shimizu, Masafumi Horie, Daichi Maeda, Richard W. Wong, Kazuyoshi Hosomichi, Takafumi Kobayashi, Satoshi Watanabe, Kenta Yamamura, Noriyuki Ohkura, Miki Abo, Seiji Yano   +23 more
wiley   +1 more source

Differential effect of supercoiling on bacterial transcription in topological domains. [PDF]

PLoS Comput Biol
Goldberg B, Yehya N, Xiao J, Meyer S.
europepmc   +1 more source

Analytical Validation of an Annotation Tool for WGS‐Based Pharmacogenomics: Preparing for Clinical Implementation in Pediatric Oncology

Clinical and Translational Science, Volume 19, Issue 4, April 2026.
Selection and validation of a whole genome sequencing pharmacogenomics annotation tool. ABSTRACT Whole genome sequencing (WGS) is increasingly accessible in clinical practice, enabling pharmacogenomics (PGx) integration, including in pediatric oncology.
Meta H. M. Diekstra, Nienke Biesot, Julie Donders, Eugène T. P. Verwiel, Alex Janse, Alwin D. R. Huitema, Lidwien M. Hanff, Bastiaan B. J. Tops, Patrick Kemmeren, Jayne Y. Hehir‐Kwa   +9 more
wiley   +1 more source

Mechanism of Action of Gepotidacin: Well-Balanced Dual-Targeting against <i>Neisseria gonorrhoeae</i> Gyrase and Topoisomerase IV in Cells and In Vitro. [PDF]

ACS Infect Dis
Oviatt AA, Collins JA, Mann CA, Huang J, Mattern K, Chan PF, Osheroff N.   +6 more
europepmc   +1 more source

Disproportionality Analysis of Fluoroquinolone‐Associated Peripheral Neuropathy in the FAERS Database (2007–2024)

Clinical and Translational Science, Volume 19, Issue 4, April 2026.
ABSTRACT Fluoroquinolones (FQs) are among the most frequently prescribed antibiotic classes worldwide. Despite their therapeutic versatility in treating bacterial infections, regulatory authorities recognized risks of persistent and potentially irreversible adverse effects, particularly peripheral neuropathy (PN).
Nimra Shamim, Kelly Doughty, Hau‐Tak Chau, James Brown, Robert Baldock, Ngan Pan Bennett Au   +5 more
wiley   +1 more source

Phytochemical Profiling and Computational Docking Studies Revealing the Potential Anticancer and Antioxidant Properties of <i>Heliotropium indicum</i> L. [PDF]

Scientifica (Cairo)
Shoily SA, Parvin MS, Kazi M, Aqib AH, Hossain MS, Ahmed R, Rafi RH, Barmon J, Uddin MN, Islam ME.   +9 more
europepmc   +1 more source

Immune cells composition in the skin and subcutaneous adipose tissue of patients with systemic sclerosis

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, Volume 24, Issue 4, Page 482-492, April 2026.
Summary Background and objectives Systemic sclerosis (SSc) is a rare, chronic autoimmune disease characterized by fibrosis of the skin and/or internal organs. Emerging evidence suggests that subcutaneous adipose tissue may contribute to systemic inflammation and fibrosis in SSc.
Marija Geroldinger‐Simić, Ana E. Aguilar González, Gerald Exler, Georg Stary   +3 more
wiley   +1 more source

A convenient single-cell assay for the newly synthesized transcriptome reveals FLI1 regulon downregulation during T cell activation. [PDF]

Cell Rep Methods
Lyu J, Xu X, Chen C.
europepmc   +1 more source

Zusammensetzung der Immunzellen in der Haut und dem subkutanen Fettgewebe von Patienten mit systemischer Sklerose

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, Volume 24, Issue 4, Page 482-493, April 2026.
Zusammenfassung Hintergrund und Ziele Systemische Sklerose (SSc) ist eine seltene, chronische Autoimmunerkrankung, die durch Fibrose der Haut und/oder der inneren Organe gekennzeichnet ist. Neue Erkenntnisse deuten darauf hin, dass subkutanes Fettgewebe zur systemischen Entzündung und Fibrose bei SSc beitragen kann.
Marija Geroldinger‐Simić, Ana E. Aguilar González, Gerald Exler, Georg Stary   +3 more
wiley   +1 more source

A Critical Analysis of the Impact of Etoposide as a Topoisomerase II Inhibitor in Cervical Cancer Treatment: A Review. [PDF]

Cancer Med
Kotian N, Reddy Y, Pai P, Sundara BK.
europepmc   +1 more source