Results 231 to 240 of about 146,499 (323)

A DifluorinatedDerivative of ARC-111 Suppresses IntrahepaticCholangiocarcinoma Growth via Targeting Topoisomerase I

Yin-Peng Bai (22032220), Mi Zhang (42795), Jian-Hua Liu (340103), Gui-Sha Chen (22032223), Cheng-Jie Yang (8301990), Nan Deng (428444), Chan-Yuan Chen (22032226), Zhi-Ping Wang (3613484), Chuan-Rui Xu (15084774), Zhi-Jun Zhang (471421), Lei Li (29537), Li-Zeng Peng (12588064), Min Liu (45756), Ying-Qian Liu (1328325)   +13 more
openalex   +1 more source

Cytocidal Activities of Topoisomerase 1 Inhibitors and 5-Azacytidine against Pheochromocytoma/Paraganglioma Cells in Primary Human Tumor Cultures and Mouse Cell Lines

, 2014
James F. Powers, Parimal Korgaonkar, Stephanie Fliedner, Alessio Giubellino, G. Gary. Sahagian Karel Pacak, Arthur S. Tischler   +5 more
openalex   +2 more sources

Dual Targeting of DNA and EGFR by ZYH005 Induces DNA Damage and Mitotic Catastrophe in Glioblastoma

MedComm, Volume 7, Issue 4, April 2026.
ZYH005 exerts potent anti‐glioblastoma activity through a dual mechanism: intercalation‐mediated DNA damage and targeted inhibition of EGFR, leading to cell cycle arrest and mitotic catastrophe. ABSTRACT Glioblastoma multiforme (GBM) is an aggressive, therapy‐resistant brain tumor with limited treatment options.
Jianzheng Huang, Zijun Zhang, Yang Xiao, Ziming Zhao, Zengwei Luo, Junjun Liu, Suitian Lai, Chao Song, Shouchang Feng, Suojun Zhang, Xingjiang Yu, Qingyi Tong, Yonghui Zhang   +12 more
wiley   +1 more source

Blue Fluorescent Siloxytecans Exhibit Potent Anticancer Activity and Enable Direct Real-Time Quantification of Intracellular Uptake. [PDF]

ACS Bio Med Chem Au
Lo I, Vaidya S, Mo A, Chia AY, Li K, Parvin J, Sadagopan S, D'souza Z, Kwok O, Zhang J, Baratoff I, Somani S, Menta L, Xie Y, Sanchez T, Wang T, Chen R, Yamamoto A, Pazzi J, Njoo E.   +19 more
europepmc   +1 more source

The Histone‐Lysine N‐Methyltransferase (KMT2) Family in Health and Disease

MedComm, Volume 7, Issue 4, April 2026.
This graphical abstract clarifies KMT2 family dysregulation and disease associations: its member mutations cause epigenetic imbalance and abnormal cell development; Menin/WDR5 inhibitors and other targeted therapies block aberrant epigenetic transcriptional programs, and combined synergistic therapies boost therapeutic efficacy.
Qiu Wang, Zunjie Bo, Ya Zhang, Yun Chen, Zhiyu Wang, Shuangmei Tong, Ajing Xu, Jian Zhang, Yan Liu   +8 more
wiley   +1 more source

Correction: Exploratory analysis of gene aberrations and chemotherapy response: findings from a real-world database in Japan. [PDF]

Br J Cancer
Ishibashi N, Kamatani T, Aoyama S, Tokunaga M, Kinugasa Y, Ikeda S.   +5 more
europepmc   +1 more source

Targeted Therapies for Each Subtype of Breast Cancer

MedComm, Volume 7, Issue 4, April 2026.
This review systematically summarizes the advances in targeted therapies for the three major molecular subtypes of breast cancer (BC), highlighting key strategies, agents, and clinical progress to guide personalized treatment. HR‐positive (luminal) BC: Dominated by estrogen receptor (ER) signaling, with endocrine therapies as the cornerstone—including ...
Aiyu Liu, Puchao Peng, Yeke Zhu, Qiuwen Fei, Weiwei Liu, Shizhen Zhang   +5 more
wiley   +1 more source

A new chapter in STI management: gepotidacin's role in gonorrhea treatment. [PDF]

Ann Med Surg (Lond)
Adnan Z, Rauf H, Raza AA, Samadi A.
europepmc   +1 more source

Combatting Drug-Resistant Bacteria with Gyrase and Topoisomerase IV Inhibitors

, 2012
Ahmed F. Abdel‐Magid
openalex   +1 more source

Topoisomerases as Targets for Novel Drug Discovery. [PDF]

Pharmaceuticals (Basel)
Perdih A.
europepmc   +1 more source