Results 291 to 300 of about 146,499 (323)
Some of the next articles are maybe not open access.
2018
This chapter discusses single-molecule approaches in the study of topoisomerases. After introducing the problem posed by DNA entanglement, it describes type I and type II topoisomerases, which solve that issue. Single-molecule assays have nailed down the different mechanisms of bacterial and eukaryotic type I topoisomerases.
David Bensimon +4 more
openaire +1 more source
This chapter discusses single-molecule approaches in the study of topoisomerases. After introducing the problem posed by DNA entanglement, it describes type I and type II topoisomerases, which solve that issue. Single-molecule assays have nailed down the different mechanisms of bacterial and eukaryotic type I topoisomerases.
David Bensimon +4 more
openaire +1 more source
DNA sequence selectivity of topoisomerases and topoisomerase poisons
Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression, 1998Chemical agents able to interfere with DNA topoisomerases are widespread in nature, and some of them have clinical efficacy as antitumor or antibacterial drugs. Drugs which have as a target DNA topoisomerases could be divided into two categories: poisons and catalytic inhibitors.
G, Capranico, M, Binaschi
openaire +2 more sources
Update on Cancer Therapeutics, 2003
Abstract This article reviews the mechanism of action, toxicity, pharmacology and clinical use of antineoplastic agents that inhibit the enzyme, topoisomerase II. Information presented in the medical and scientific literature in the past 3 years is especially highlighted.
openaire +2 more sources
Abstract This article reviews the mechanism of action, toxicity, pharmacology and clinical use of antineoplastic agents that inhibit the enzyme, topoisomerase II. Information presented in the medical and scientific literature in the past 3 years is especially highlighted.
openaire +2 more sources
DNA topoisomerases and topoisomerase inhibitors.
Pathologie-biologie, 1995DNA topoisomerases are ubiquitous nuclear enzymes, essential for several steps of DNA metabolism. They have recently been shown to be specific targets of a number of anticancer agents. In this review are discussed the most recent discoveries in the physiology and the molecular biology of DNA topoisomerases, and the mechanism of interaction with drugs ...
openaire +1 more source
Topoisomerases and Carcinogenesis: Topoisomerase IIIα and BLM
2011In human cells, Topoisomerase IIIα (Top3α) is the main partner of BLM, the Bloom syndrome (BS) helicase. BS constitutes a genetic and clinical model for recessive cancer predisposition and study of this disease may help to decipher pathways of carcinogenesis in the general population.
Mounira Amor-Guéret +1 more
openaire +1 more source
2005
Abstract Virtually every reaction that occurs in biological systems is catalysed by an enzyme. The interconversions of the different topological forms of DNA are no exceptions. The enzymes that catalyse these processes are known as DNA topoisomerases and constitute a widespread and fascinating group.
Andrew D Bates, Anthony Maxwell
openaire +1 more source
Abstract Virtually every reaction that occurs in biological systems is catalysed by an enzyme. The interconversions of the different topological forms of DNA are no exceptions. The enzymes that catalyse these processes are known as DNA topoisomerases and constitute a widespread and fascinating group.
Andrew D Bates, Anthony Maxwell
openaire +1 more source