Results 101 to 110 of about 32,790 (255)
New Life of Topoisomerase I Inhibitors as Antibody-Drug Conjugate Warheads. [PDF]
Clin Cancer Res, 2023 Pommier Y, Thomas A.
europepmc +1 more source
Journal of Applied Toxicology, EarlyView.ABSTRACT One of the most serious complications associated with the use of the chemotherapeutic agent doxorubicin (DOX) is cardiomyopathy. Although cardioprotective drugs such as angiotensin receptor‐neprilysin inhibitors (ARNI) are used to prevent cardiomyopathy in DOX patients, no studies have reported the relationship between ARNI and endoplasmic ...
Mert Unvan +3 more
wiley +1 more source
Epirubicin Alters Pancreatic Autophagy and Insulin Synthesis Through a Zinc‐Dependent Mechanism
Journal of Applied Toxicology, EarlyView.ABSTRACT Epirubicin (EPI) can cause metabolic side effects, including chemotherapy‐related diabetes, partly through oxidative stress that disrupts zinc (Zn) homeostasis and impairs autophagy. This study investigated the effects of EPI on Zn regulation and autophagy in the pancreas, as well as the modulatory role of N‐acetylcysteine (NAC). Rats received
Ebru Afşar, Işıl Eranıl
wiley +1 more source
, 2012 PhDThe protozoan parasites Trypanosoma cruzi and Trypanosoma brucei are the causative agents of Chagas disease and Human African sleeping sickness respectively.
Bot, Christopher
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Topoisomerase enzymes as therapeutic targets for cancer chemotherapy
, 2005 The topoisomerase enzymes are essential for DNA metabolism, where they act to adjust the number of supercoils in DNA, a key requirement in the cellular processes of transcription and replication. Their enzymatic mechanism creates transient nicks (type I)
Sharma, Ram P., Giles, Gregory I.
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Journal of Applied Toxicology, EarlyView.ABSTRACT A Cu(II) complex derived from a pyrimidine with the isatin group was synthesized and tested for its cytotoxic effects on A549 lung cancer and MCF‐7 breast cancer cell lines, as well as its effects on apoptosis‐associated cell death and cell cycle regulation in A549 cells. To evaluate cytotoxicity, MTT assays were performed at 24, 48, and 72 h,
Müjgan Kesik Oktay +4 more
wiley +1 more source
Effect of safranal on the response of cancer cells to topoisomerase I inhibitors: Does sequence matter? [PDF]
Front Pharmacol, 2022 Lozon L +5 more
europepmc +1 more source
Experiencing 50 Years of Synergistic Development in Structural Biology and Enzymology
Journal of the Chinese Chemical Society, EarlyView.Picture of Sunney Chan with Academia Sinica (AS) President James C. Liao and three Vice Presidents: Shin‐Kun Peng (left one), Tang K. Tang (right one), and Mei‐Yin Chou (right 2), taken at the annual Chinese New Year's Banquet of AS, February 7, 2025. This was likely Sunney's last appearance in formal activities of AS.
Ming‐Daw Tsai
wiley +1 more source
Targeting neddylation sensitizes colorectal cancer to topoisomerase I inhibitors by inactivating the DCAF13-CRL4 ubiquitin ligase complex. [PDF]
Nat Commun, 2023 Sun Y +24 more
europepmc +1 more source
Benzothiazole derivatives as human DNA topoisomerase IIα inhibitors [PDF]
, 2020 Benzothiazole derivatives resembling the structure of DNA purine bases were tested to determine their topoisomerase inhibition activities. Based on DNA topoisomerase I and II relaxation assay results, all 12 derivatives acted as human topoisomerase IIa ...
Cigdem Kaplan-Ozen +6 more
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