Results 111 to 120 of about 60,395 (277)

Antimicrobial Resistance in Neisseria gonorrhoeae: Proceedings of the STAR Sexually Transmitted Infection-Clinical Trial Group Programmatic Meeting. [PDF]

, 2019
The goal of the Sexually Transmitted Infection Clinical Trial Group's Antimicrobial Resistance (AMR) in Neisseria gonorrhoeae (NG) meeting was to assemble experts from academia, government, nonprofit and industry to discuss the current state of research,
Bristow, Claire C, Cristillo, Anthony D, Dillon, Jo-Anne, Dong, Huan, Grad, Yonatan H, Kirkcaldy, Robert D, Klausner, Jeffrey D, Lawrence, Kenneth, Morris, Sheldon R, Nicholas, Robert A, Oldach, David, Rice, Peter A, Shafer, William Maurice, Torrone, Elizabeth, Wi, Teodora E, Zhou, Pei   +15 more
core   +1 more source

Synthetic Inhibitors of DNA Topoisomerase I and II.

Chemical and Pharmaceutical Bulletin, 1999
A new type of synthetic inhibitor of DNA topoisomerase I and II was examined and several of these derivatives exhibited strong dual activity against these enzymes. This series of compounds showed high cytotoxic activities against cancer cells, but only a limited number of compounds showed any noticeable activity in an in vivo test against murine P388 ...
H, Katayama, Y, Kawada, K, Kaneko, T, Oshiyama, N, Takatsu   +4 more
openaire   +3 more sources

Recent advances in noncanonical inhibition mechanisms of anti‐CRISPR proteins

mLife, EarlyView.
Abstract The CRISPR‐Cas system constitutes an adaptive immune mechanism in prokaryotes that defends against mobile genetic elements. Within the perpetual co‐evolutionary arms race between bacteria and their viral predators, bacteriophages encode anti‐CRISPR (Acr) proteins that use sophisticated molecular strategies to sabotage CRISPR‐Cas function ...
Lingguang Yang, Rongjun Luo, Wei Zhou, Peipei Yin, Yue Feng, Yi Zhang   +5 more
wiley   +1 more source

New Life of Topoisomerase I Inhibitors as Antibody-Drug Conjugate Warheads. [PDF]

Clin Cancer Res, 2023
Pommier Y, Thomas A.
europepmc   +1 more source

Harnessing Phytochemicals for Brain Cancer Therapy: Insights Into Medulloblastoma and Glioblastoma Treatment

Phytochemical Analysis, EarlyView.
ABSTRACT Primary brain tumors are life‐threatening diseases. Glioblastoma is the most aggressive type with a poor prognosis. Medulloblastoma is the most common pediatric brain tumor. While surgical treatments often result in recurrences owing to the complex nature of the tumor microenvironment, conventional treatments lower the quality of life of ...
Ilkay Irem Ozbek, Mesra Aktas, Hale Saybasili, Kutlu O. Ulgen   +3 more
wiley   +1 more source

Pharmacological treatment with inhibitors of nuclear export enhances the antitumor activity of docetaxel in human prostate cancer [PDF]

, 2017
Background and aims: Docetaxel (DTX) modestly increases patient survival of metastatic castration-resistant prostate cancer (mCRPC) due to insurgence of pharmacological resistance. Deregulation of Chromosome Region Maintenance (CRM-1)/ exportin-1 (XPO-1)-
Argueta, Christian, BIORDI, ASSUNTA LEDA, Biordi, Leda Assunta, Colapietro, Alessandro, Festuccia, Claudio, Flati, Vincenzo, Gravina, Giovanni Luca, Iorio, Roberto, Kauffman, Michael, Landesman, Yosef, Mancini, Andrea, Marampon, Francesco, Pompili, Simona, Sferra, Roberta, Shacham, Sharon   +14 more
core   +2 more sources

Polyhedral Oligomeric Silsesquioxane Based Material for Tumor Heterogeneity MR Visualization and Precise Treatment

SusMat, EarlyView.
ABSTRACT Malignant tumors whose mortality rates up to 97% possess high heterogeneity that leads to rapid growth, strong invasive capability, and low drug sensitivity. Quantitative magnetic resonance imaging enables direct visualization of tumors. However, gadolinium‐based contrast agents used in clinical practice have significant drawbacks of short ...
Xiaochuan Geng, Zhiguo Zhuang, Jiahui Zhang, Xinxin Zhao, Haiying Lyu, Zi Fu, Xi Liu, Ting Qian, Zhihui Li, Tongtong Chen, Qing Zhang, Yan Zhou, Yong Lu, Gang Wei   +13 more
wiley   +1 more source

Effect of safranal on the response of cancer cells to topoisomerase I inhibitors: Does sequence matter? [PDF]

Front Pharmacol, 2022
Lozon L, Saleh E, Menon V, Ramadan WS, Amin A, El-Awady R.   +5 more
europepmc   +1 more source

Deciphering diverse cell‐death patterns to predict the prognosis and potential therapy target of hepatocellular carcinoma patients

VIEW, EarlyView.
Abstract Ninety percent of all primary liver malignancies are hepatocellular carcinomas (HCC), making liver cancer the third most common cause of cancer‐associated mortality. Different patterns of programmed cell death (PCD) are crucial for the survival of tumors, and they might serve as a prognostic marker for HCC.
Lin Ding, Qian Li, Wenjing Yang, Te Liu, Tongtong Tian, Yu Liu, Chunyan Zhang, Baishen Pan, Beili Wang, Fan Wu, Wei Guo   +10 more
wiley   +1 more source

The application of click chemistry in the synthesis of agents with anticancer activity

Drug Design, Development and Therapy, 2015
Nan Ma,1–3 Ying Wang,3 Bing-Xin Zhao,3 Wen-Cai Ye,1,3 Sheng Jiang2 1Department of Natural Medicinal Chemistry, China Pharmaceutical University, Nanjing, 2Laboratory of Medicinal Chemistry, Guangzhou Institute of Biomedicine and Health ...
Ma N, Wang Y, Zhao BX, Ye WC, Jiang S
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