Results 151 to 160 of about 60,395 (277)
Transcriptomic profiling and quantitative high-throughput (qHTS) drug screening of CDH1 deficient hereditary diffuse gastric cancer (HDGC) cells identify treatment leads for familial gastric cancer [PDF]
, 2017 Chen, Ina, et al,
core +2 more sources
Investigating the protective role of the natural hormone Melatonin, in reducing drug-induced cardiotoxicity in the therapy of chronic diseases [PDF]
, 2019 Heart failure (HF) is a highly complex disorder and a major end-point of cardiovascular diseases (CVD). The pathogenesis of HF is mostly unresolved but involves interplay between cardiac structural and electrical remodelling, metabolic alterations, cell ...
Kasi Ganeshan, T., Kasi Ganeshan, T.
core
Accessing New Phenanthroline–Oxazine Scaffolds as Copper‐Dependent DNA Damaging Probes
ChemBioChem, Volume 27, Issue 8, 28 April 2026.New phenanthroline–oxazine ligands derived from natural amino acids are synthesized through an optimized, predictive strategy. When coordinated to copper, these scaffolds display tunable DNA binding, groove selectivity, and oxidative cleavage activity, revealing clear structure activity relationships and expanding the toolbox of copper‐dependent ...
Rebecca Lynn +10 more
wiley +1 more source
BRCAness, SLFN11, and RB1 loss predict response to topoisomerase I inhibitors in triple-negative breast cancers. [PDF]
Sci Transl Med, 2020 Coussy F +33 more
europepmc +1 more source
ChemPhysChem, Volume 27, Issue 8, 28 April 2026.The solvation preference of irinotecan is governed by a competition between cavity formation and electrostatic stabilization. Computations reveal that the high cost of breaking water's hydrogen bond network outweighs its electrostatic benefits. In contrast, polar aprotic solvents (e.g., pyridine) offer an optimal thermodynamic balance, providing strong
Martin M. Bitabo +4 more
wiley +1 more source
Metalloids: Semi as Metals yet Full of Antimicrobial Potential
ChemMedChem, Volume 21, Issue 7, 14 April 2026.Metalloids such as boron (B), silicon (Si), germanium (Ge), arsenic (As), antimony (Sb), and tellurium (Te) bridge metals and non‐metals, displaying unique chemical versatility. Recent research highlights their diverse antimicrobial and therapeutic potentials, from natural products to synthetic organic and organometallic molcules, underscoring renewed ...
Kevin Böhm +2 more
wiley +1 more source
Molecular pathways involved in the mechanisms of cytoprotection by aspirin in cancer cells [PDF]
, 2007 Di Palma, Antonella
core +1 more source