Results 161 to 170 of about 32,790 (255)

Phosphine Oxide Indenoquinoline Derivatives: Synthesis and Biological Evaluation as Topoisomerase I Inhibitors and Antiproliferative Agents. [PDF]

Molecules
Rodriguez-Paniagua A, Tesauro C, Knudsen BR, Fuertes M, Alonso C.   +4 more
europepmc   +1 more source

Novel clinical indenoisoquinoline topoisomerase I inhibitors: a twist around the camptothecins. [PDF]

Oncotarget, 2018
Pommier Y, Cushman M, Doroshow JH.
europepmc   +1 more source

Antibiotics in Veterinary Ophthalmology: Resistance, Stewardship, and Emerging Antibiotic‐Sparing Strategies

Veterinary Ophthalmology, Volume 29, Issue 4, July 2026.
ABSTRACT Antimicrobial resistance (AMR) is a growing challenge in veterinary ophthalmology, particularly in cases of bacterial keratitis, where progressive stromal infection can threaten vision and globe integrity within hours to days. This review synthesizes current evidence on pathogen distribution, antimicrobial susceptibility profiles, multidrug ...
Lionel Sebbag, Oren Pe'er
wiley   +1 more source

Unveiling the Anticancer Potential: Computational Exploration of Nitrogenated Derivatives of (+)-Pancratistatin as Topoisomerase I Inhibitors. [PDF]

Int J Mol Sci
Mohamed MA, Elsaman T, Elderdery AY, Alsrhani A, Ghanem HB, Alruwaili MM, Hamza SMA, Mekki SEI, Alotaibi HA, Mills J.   +9 more
europepmc   +1 more source

Optimisation of a Novel Class of DNA Gyrase Inhibitors to Improve Antibacterial Activity

ChemMedChem, Volume 21, Issue 11, 15 June 2026.
This article describes efforts to increase the antibacterial activity of a recently reported class of novel DNA gyrase inhibitors known as the isoquinoline sulphonamides by improving their uptake in bacterial cells. As antibiotic resistance continues to rise, the need for new antibacterials is clear.
Meg I. Ferguson, Cerissa C. van Walstijn, Vladyslav Lysenko, Marta A. Wilbrink, David Alencar Araripe, Jeroen M. Punt, Mario van der Stelt, Willem Jespers, Paolo Innocenti, Nathaniel I. Martin   +9 more
wiley   +1 more source

Pursuing Polypharmacology: Benzothiopyranoindoles as G-Quadruplex Stabilizers and Topoisomerase I Inhibitors for Effective Anticancer Strategies. [PDF]

ACS Med Chem Lett
Salerno S, Barresi E, Roggia M, Natale B, Marzano S, Hyeraci M, Reina SCR, Baglini E, Amato J, Salvati E, Dalla Via L, Da Settimo F, Cosconati S, Taliani S.   +13 more
europepmc   +1 more source

Small DNA circles as bacterial topoisomerase I inhibitors. [PDF]

RSC Adv, 2019
Li D, Wang Q, Zhou B, Zhuge Q, Lv B.
europepmc   +1 more source

Topoisomerase I Inhibitor LMP776 [PDF]

, 2020
openaire   +1 more source

Machine Learning Models Combined with Virtual Screening and Molecular Docking to Predict Human Topoisomerase I Inhibitors. [PDF]

Molecules, 2019
Li B, Kang X, Zhao D, Zou Y, Huang X, Wang J, Zhang C.   +6 more
europepmc   +1 more source

New Benzimidazole-Triazole Derivatives as Topoisomerase I Inhibitors: Design, Synthesis, Anticancer Screening, and Molecular Modeling Studies. [PDF]

ACS Omega
Çevik UA, Kaya B, Celik I, Rudrapal M, Rakshit G, Karayel A, Levent S, Osmaniye D, Sağlık Özkan BN, Baysal M, Atlı Ekliog Lu Ö, Özkay Y, Kaplancıklı ZA.   +12 more
europepmc   +1 more source