Results 181 to 190 of about 60,395 (277)

Developing a Phosphospecific IHC Assay as a Predictive Biomarker for Topoisomerase I Inhibitors. [PDF]

J Histochem Cytochem, 2018
Ando K, Tohme YH, Srinivasiah A, Taylor-Parker J, Harrington Y, Shah AK, Oki E, Brahmandam M, Bharti AK.   +8 more
europepmc   +1 more source

Geminin deficiency enhances survival in a murine medulloblastoma model by inducing apoptosis of preneoplastic granule neuron precursors [PDF]

, 2017
Dearborn, Joshua, Kroll, Kristen L, Lewis, Emily M, Patterson, Ethan, Rubin, Joshua B, Sankar, Savita, Tong, Caili, Waller, Laura E, Wozniak, David   +8 more
core   +2 more sources

Protective Effect of Silymarin Against Paclitaxel‐Induced Cardiotoxicity

Food Science &Nutrition, Volume 14, Issue 4, April 2026.
Paclitaxel, a potent chemotherapeutic agent, induces oxidative stress, inflammation, and apoptosis leading to cardiotoxicity. In this study, silymarin supplementation significantly reduced oxidative stress markers, downregulated inflammatory cytokines (IL‐1β, TNF‐α, NF‐κB), and restored the balance between pro‐ and anti‐apoptotic proteins in rat heart ...
Tuğçe Tutar, Seda Yakut, Adem Kara, Aykut Ulucan, Cüneyt Çağlayan   +4 more
wiley   +1 more source

The Effect of Topoisomerase I Inhibitors on the Efficacy of T-Cell-Based Cancer Immunotherapy. [PDF]

J Natl Cancer Inst, 2018
McKenzie JA, Mbofung RM, Malu S, Zhang M, Ashkin E, Devi S, Williams L, Tieu T, Peng W, Pradeep S, Xu C, Zorro Manrique S, Liu C, Huang L, Chen Y, Forget MA, Haymaker C, Bernatchez C, Satani N, Muller F, Roszik J, Kalra A, Heffernan T, Sood A, Hu J, Amaria R, Davis RE, Hwu P.   +27 more
europepmc   +1 more source

Clinical validation of a DNA methylation biomarker associated with overall survival of relapsed ovarian cancer patients

International Journal of Cancer, Volume 158, Issue 7, Page 1821-1835, 1 April 2026.
What's new? Most patients with ovarian cancer (OC) relapse after first‐line chemotherapy, and prognosis with second‐line treatment depends largely on the platinum‐free interval. However, reliable biomarkers to predict response to second‐line therapy remain lacking.
Muhammad Habiburrahman, Nahal Masrour, Naina Patel, Anna M. Piskorz, Robert Brown, James D. Brenton, Iain A. McNeish, James M. Flanagan   +7 more
wiley   +1 more source

Discovery of novel bacterial topoisomerase I inhibitors by use of in silico docking and in vitro assays. [PDF]

Sci Rep, 2018
Sandhaus S, Chapagain PP, Tse-Dinh YC.
europepmc   +1 more source

Exposure‐Response Analyses of Datopotamab Deruxtecan (Dato‐DXd) in Patients with Hormone Receptor (HR) Positive, Human Epidermal Growth Factor Receptor 2 (HER2)‐Negative Breast Cancer

The Journal of Clinical Pharmacology, Volume 66, Issue 4, April 2026.
Abstract Dato‐DXd (datopotamab deruxtecan) is an anti‐TROP2 antibody‐drug conjugate developed for the treatment of unresectable or metastatic hormone receptor‐positive, human epidermal growth factor receptor 2‐negative breast cancer (HR+/HER2‐BC) who have received prior endocrine‐based therapy and chemotherapy for unresectable or metastatic disease ...
Zoey Tang, KyoungSoo Lim, Yu Jiang, Neelima Denduluri, Nana Rokutanda, Yuzhuo Pan, Ying Hong, Song Ren, Pavan Vajjah, Diansong Zhou   +9 more
wiley   +1 more source

Characterization of new, efficient Mycobacterium tuberculosis topoisomerase-I inhibitors and their interaction with human ABC multidrug transporters. [PDF]

PLoS One, 2018
Temesszentandrási-Ambrus C, Tóth S, Verma R, Bánhegyi P, Szabadkai I, Baska F, Szántai-Kis C, Hartkoorn RC, Lingerfelt MA, Sarkadi B, Szakács G, Őrfi L, Nagaraja V, Ekins S, Telbisz Á.   +14 more
europepmc   +1 more source

Topoisomerase I Inhibitor Genz-644282 [PDF]

, 2020
openaire   +1 more source

The Mechanism of Gut Microbiota in Breast Cancer Based on the Bulk Transcriptome, Mendelian Randomization Analysis and Single Cell RNA Sequencing

MicrobiologyOpen, Volume 15, Issue 2, April 2026.
This multi‐omics study defines the gut microbiota‐driven MCM6/NR3C1 axis as a key driver of breast cancer, providing robust biomarkers for early diagnosis and actionable therapeutic targets. ABSTRACT Breast cancer (BC) is the leading cause of cancer death in women.
Tianyu Luo, Mengyao Xue, Yi Du, Huiying Chen, Ying Sun, Haidong Sun   +5 more
wiley   +1 more source