Results 181 to 190 of about 32,790 (255)

Exploring the Role of Topoisomerase II Beta in Macrophage Maturation and Pro-inflammatory Cytokine Production

Although it is known that DNA topo IIβis required for the regulation of transcription during neural development and differentiation, it is not clear whether the enzyme is required during differentiation of human monocytes into macrophages and/or the ...
Roythorne, Ashleigh
core  

Current Role of Topoisomerase I Inhibitors for the Treatment of Mesenchymal Malignancies and Their Potential Future Use as Payload of Sarcoma-Specific Antibody-Drug Conjugates.

Oncol Res Treat
Schöffski P, Wang CC, Schöffski MP, Wozniak A.   +3 more
europepmc   +1 more source

Novel bivalent securinine mimetics as topoisomerase I inhibitors. [PDF]

Medchemcomm, 2017
Hou W, Lin H, Wang ZY, Banwell MG, Zeng T, Sun PH, Lin J, Chen WM.   +7 more
europepmc   +1 more source

PAF1c depletion confers chemoresistance to topoisomerase inhibitors. [PDF]

Cell Insight
Li D, Zhu C, Wang T, Chen Q, Chen Q.
europepmc   +1 more source

HIF inhibition: Current strategies and clinical challenges. [PDF]

Redox Biol
Więch-Walów A, Bartoszewska S, Barton A, Czechowicz P, Dudzik J, Wielockx B, Collawn JF, Bartoszewski R.   +7 more
europepmc   +1 more source

Characterization of Alternaria alternata alternariol monomethyl ether with a potential antiproliferative activity by topoisomerases inhibition; molecular docking and dynamic simulations. [PDF]

Sci Rep
El-Sayed ASA, Aboelez MO, Ezelarab HAA, Ewedah TM, El-Baz AF, Ashraf R, Diab A, Safwat G, Rady AM, El-Mekkawy RM.   +9 more
europepmc   +1 more source

Dual-acting histone deacetylase-topoisomerase I inhibitors. [PDF]

Bioorg Med Chem Lett, 2013
Guerrant W, Patil V, Canzoneri JC, Yao LP, Hood R, Oyelere AK.   +5 more
europepmc   +1 more source

A high-throughput fluorescent DNA cleavage assay for discovering bacterial DNA gyrase poisons. [PDF]

Nucleic Acids Res
Dias M, Annamalai T, Otsuka Y, Leng S, Chapagain T, Ferdous S, Shumate J, Scampavia L, Spicer TP, Leng F.   +9 more
europepmc   +1 more source

Molecular Determinants of Response and Rational Drug Combinations for Antibody-Drug Conjugates (ADCs) with Topoisomerase I (TOP1) Inhibitor Payloads. [PDF]

J Mol Biol
Pommier Y.
europepmc   +1 more source

Structure-Based Drug Design Targeting Topoisomerase II Alpha: Discovery of Potential Antitumor Xanthone Derivatives. [PDF]

Molecules
Le TTH, Nguyen TNH, Pham MQ, Tran TTT, Dinh TT, Tran THV, Tran VL, Pham QL.   +7 more
europepmc   +1 more source