Results 61 to 70 of about 61,437 (248)

Bulge oligonucleotide as an inhibitory agent of bacterial topoisomerase I

Journal of Enzyme Inhibition and Medicinal Chemistry, 2018
Bacterial topoisomerase I (Btopo I) was defined as potential target for discovery of new antibacterial compounds. Various oligonucleotides containing bulge structure were designed and synthesised as inhibitors to Btopo I in this investigation.
Zhaoqi Yang, Tuoyu Jiang, Hanshi Zhong, Yu Kang   +3 more
doaj   +1 more source

DNA-Binding Anticancer Drugs: One Target, Two Actions

Molecules, 2021
Amsacrine, an anticancer drug first synthesised in 1970 by Professor Cain and colleagues, showed excellent preclinical activity and underwent clinical trial in 1978 under the auspices of the US National Cancer Institute, showing activity against acute ...
Bruce C. Baguley, Catherine J. Drummond, Ying Yi Chen, Graeme J. Finlay   +3 more
doaj   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

DIVERSet JAG compounds inhibit topoisomerase II and are effective against adult and pediatric high-grade gliomas [PDF]

, 2019
High-grade gliomas (HGGs) are aggressive primary brain tumors with local invasive growth and poor clinical prognosis in both adult and pediatric patients.
Ajaz, Allen, An, Bristow, Broniscer, Broniscer, Cohen, Cohen, Demoulin, Dolecek, Dolgin, Dubey, Felsberg, Feun, Fillmore, Froelich-Ammon, Gewirtz, Hill, Hsieh, Joseph, Korones, Kreis, Lee, Livak, Louis, Mackay, Mehta, Mehta, Merighi, Montenegro, Northcott, Ostrom, Pace, Pollack, Pollack, Pollack, Pollack, Prados, Prados, Shaw, Sirenko, Sonabend, Stupp, Stupp, Sure, Uribe, van den Bent, Waldman, Wijdeven, Wilson, Wu, Yung   +51 more
core   +2 more sources

Topoisomerase I inhibitors: Review and update

Annals of Oncology, 1997
This review presents a summary of preclinical and clinical data on the topoisomerase I (topo I) inhibitors that are under clinical development. To date, all of the topo I inhibitors that have been clinically evaluated are analogues of camptothecin, an extract of the Chinese tree Camptotheca acuminata.
openaire   +2 more sources

Dietary nitrate and nitrite protect against doxorubicin‐induced cardiac fibrosis and oxidative protein damage in tumor‐bearing mice

FEBS Open Bio, EarlyView.
Chemotherapies such as doxorubicin can have toxic effects on healthy cardiovascular/heart tissue. Following up on a doxorubicin toxicity study in mice without tumors where nitrate water was cardioprotective (lessened toxicity), this study with tumor‐bearing mice undergoing doxorubicin treatment showed no negative effect of nitrate and nitrite on drug ...
Rama D. Yammani, Xiaofei Chen, Nildris Cruz‐Diaz, Xuewei Zhu, Swati Basu, Daniel B. Kim‐Shapiro, David R. Soto‐Pantoja, Leslie B. Poole   +7 more
wiley   +1 more source

Review and Current Perspectives on DNA Topoisomerase I and II Enzymes of Fungi as Study Models for the Development of New Antifungal Drugs

Journal of Fungi
Fungal infections represent a growing public health problem, mainly stemming from two phenomena. Firstly, certain diseases (e.g., AIDS and COVID-19) have emerged that weaken the immune system, leaving patients susceptible to opportunistic pathogens ...
Dulce Andrade-Pavón, Omar Gómez-García, Lourdes Villa-Tanaca   +2 more
doaj   +1 more source

Identification of a novel topoisomerase inhibitor effective in cells overexpressing drug efflux transporters. [PDF]

PLoS ONE, 2009
BACKGROUND:Natural product structures have high chemical diversity and are attractive as lead structures for discovery of new drugs. One of the disease areas where natural products are most frequently used as therapeutics is oncology. METHOD AND FINDINGS:
Walid Fayad, Mårten Fryknäs, Slavica Brnjic, Maria Hägg Olofsson, Rolf Larsson, Stig Linder   +5 more
doaj   +1 more source

Clinical outcome and prognostic factors in renal medullary carcinoma: a pooled analysis from 18 years of medical literature [PDF]

, 2015
INTRODUCTION: We describe clinical features and prognostic factors of renal medullary carcinoma (RMC) by performing a pooled analysis of all reported cases since 1995.
CORTESI, Enrico, IACOVELLI, ROBERTO, MODICA, DANIELA, PALAZZO, ANTONELLA, PIESCO, GABRIELE, TRENTA, PATRIZIA   +5 more
core   +1 more source

A 3D Bioprinted Spheroid‐Laden dECM‐Enriched Osteosarcoma Model for Enhanced Drug Testing and Therapeutic Discovery

Advanced Healthcare Materials, EarlyView.
A 3D biomimetic OS model was developed by bioprinting an OS‐cell‐derived dECM‐enriched bioink with OS spheroids incorporated. The model showed upregulation of known OS prognostic markers and increased resistance to doxorubicin, compared to 2D cultures and scaffold‐free spheroids, making this a more clinically relevant platform for drug discovery ...
Margarida F. Domingues, Maria Catarina Carreira, Mafalda S. Santos, Daniela Pacheco, Frederico Castelo Ferreira, Paola Sanjuan‐Alberte, João Carlos Silva   +6 more
wiley   +1 more source