Results 11 to 20 of about 6,410,919 (241)

Topoisomerase-II mediated biochemical mapping of centromeres and nitroreductase mediated drug metabolism in Trypanosomatids [PDF]

, 2012
PhDThe protozoan parasites Trypanosoma cruzi and Trypanosoma brucei are the causative agents of Chagas disease and Human African sleeping sickness respectively.
Bot, Christopher
core   +4 more sources

CRAMP1-dependent histone H1 biogenesis is essential for topoisomerase II inhibitor tolerance. [PDF]

Mol Cell
Raw uncropped, unprocessed western blots, microscopy representative images and statistical source data for our manuscript titled 'CRAMP1-dependent histone H1 biogenesis is essential for topoisomerase II inhibitor tolerance'
Ingham A, de Vega IA, Morlot L, Gittens W, Hendriks IA, Kakulidis ES, Freire R, Davey NE, Duxin JP, Lund Nielsen M, Mailand N.   +10 more
europepmc   +2 more sources

MSN8C: A Promising Candidate for Antitumor Applications as a Novel Catalytic Inhibitor of Topoisomerase II

Molecules, 2023
MSN8C, an analog of mansonone E, has been identified as a novel catalytic inhibitor of human DNA topoisomerase II that induces tumor regression and differs from VP-16(etoposide).
Jie-Bin Ou, Wei-Hao Huang, Xing-Zi Liu, Guo-Yao Dai, Lu Wang, Zhi-Shu Huang, Shi-Liang Huang   +6 more
doaj   +1 more source

DNA topoisomerase II is involved in regulation of cyst wall protein genes and differentiation in Giardia lamblia. [PDF]

PLoS Neglected Tropical Diseases, 2013
The protozoan Giardia lamblia differentiates into infectious cysts within the human intestinal tract for disease transmission. Expression of the cyst wall protein (cwp) genes increases with similar kinetics during encystation.
Bo-Chi Lin, Li-Hsin Su, Shih-Che Weng, Yu-Jiao Pan, Nei-Li Chan, Tsai-Kun Li, Hsin-Chih Wang, Chin-Hung Sun   +7 more
doaj   +1 more source

Inhibition of Poly(ADP-Ribose) polymerase enhances the toxicity of 131I-Metaiodobenzylguanidine/Topotecan combination therapy to cells and xenografts that express the noradrenaline transporter [PDF]

, 2012
Targeted radiotherapy using [131I]meta-iodobenzylguanidine ([131I]MIBG) has produced remissions in some neuroblastoma patients. We previously reported that combining [131I]MIBG with the topoisomerase I (Topo-I) inhibitor topotecan induced long-term DNA ...
McCluskey, Anthony G, Babich, John W, Champion, Sue, Mairs, Robert J, Boyd, Marie, Gaze, Mark N, Tesson, Mathias, Pimlott, Sally L   +7 more
core   +4 more sources

15-deoxy-Δ12, 14-prostaglandin J2 enhances anticancer activities independently of VHL status in renal cell carcinomas

Biochemistry and Biophysics Reports, 2019
Renal cell carcinoma (RCC) is relatively resistant to chemotherapy and radiotherapy. Clear cell RCC (ccRCC) accounts for the majority of RCC, which have mutations or epigenetic silencing of the von Hippel–Lindau (VHL) gene.
Hiromi Koma, Yasuhiro Yamamoto, Tomonari Fujita, Tatsurou Yagami   +3 more
doaj   +1 more source

Therapy Related Acute Promyelocytic Leukaemia (APML) in a Breast Cancer Survivor: Another Tale of an Ally Turned Adversary [PDF]

Journal of Clinical and Diagnostic Research, 2019
With an increase in the use of high dose chemotherapeutic regimens, higher cure rates and longer survival periods of cancer patients, the incidence of secondary malignancies are increasing.
Sujaya Mazumder, Debdatta Basu, Biswajit Dubashi   +2 more
doaj   +1 more source

MRE11 facilitates the removal of human topoisomerase II complexes from genomic DNA [PDF]

, 2012
Topoisomerase II creates a double-strand break intermediate with topoisomerase covalently coupled to the DNA via a 5'-phosphotyrosyl bond. These intermediate complexes can become cytotoxic protein-DNA adducts and DSB repair at these lesions requires ...
Caroline A. Austin, Graham H. Jackson, Nicholas J. Morris, Zbyslaw Sondka, Tainer, JA, Padget, Kay, Simon J. Cockell, Curtis, H, Cockell, SJ, Curtis, Hannah, Sondka, Zbyslaw, Austin, CA, John A. Tainer, Cowell, IG, Austin, Caroline, Padget, K, Morris, Nicholas, Moiani, Davide, Cowell, Ian, Ian G. Cowell, Sondka, Z, Lee, KC, Tainer, John, Jackson, Graham, Kay Padget, Moiani, D, Lee, Ka Cheong, Jackson, GH, Ka Cheong Lee, Davide Moiani, Hannah Curtis, Morris, NJ, Cockell, Simon   +32 more
core   +1 more source

A role for topoisomerase II alpha in chromosome damage in human cell lines [PDF]

, 2010
Human response to ionising radiation (IR) shows a wide variation. This is most clearly seen in the radiation-response of cells as measured by frequencies of chromosomal aberrations.
Terry, Samantha Y.A.
core   +2 more sources

The impact of the C-terminal domain on the interaction of human DNA topoisomerase II α and β with DNA [PDF]

, 2011
<b>Background</b> Type II DNA topoisomerases are essential, ubiquitous enzymes that act to relieve topological problems arising in DNA from normal cellular activity.
Caroline A. Austin, Kathryn L Gilroy, Caroline A Austin, Austin Caroline A., Austin, C.A., Gilroy Kathryn L., Gilroy, K.L., Kathryn L. Gilroy   +7 more
core   +2 more sources