Results 21 to 30 of about 6,410,919 (241)

Discovery of Novel Triazole-Containing Pyrazole Ester Derivatives as Potential Antibacterial Agents

Molecules, 2019
To develop new antibacterial agents, a series of novel triazole-containing pyrazole ester derivatives were designed and synthesized and their biological activities were evaluated as potential topoisomerase II inhibitors.
Ming-Jie Chu, Wei Wang, Zi-Li Ren, Hao Liu, Xiang Cheng, Kai Mo, Li Wang, Feng Tang, Xian-Hai Lv   +8 more
doaj   +1 more source

Inhibitors of ABCB1 and ABCG2 overcame resistance to topoisomerase inhibitors in small cell lung cancer

Thoracic Cancer, 2022
Background Small cell lung cancer (SCLC) is a highly aggressive disease with a poor prognosis. Although most patients initially respond to topoisomerase inhibitors, resistance rapidly emerges.
Miwako Omori, Rintaro Noro, Masahiro Seike, Kuniko Matsuda, Mariko Hirao, Aya Fukuizumi, Natsuki Takano, Akihiko Miyanaga, Akihiko Gemma   +8 more
doaj   +1 more source

Topoisomerase II inhibition involves characteristic chromosomal expression patterns

BMC Genomics, 2008
Background The phenomenon of co-localization of transcriptionally upregulated genes showing similar expression levels is known across all eukaryotic genomes.
Borlak Jürgen, Reymann Susanne
doaj   +1 more source

Lapcin, a potent dual topoisomerase I/II inhibitor discovered by soil metagenome guided total chemical synthesis

Nature Communications, 2022
Chemical synthesis of secondary metabolites isolated from nature, and derivatives thereof, is still a paradigm of significance to drug development. Here the authors instead use bioinformatics to analyze a biosynthetic gene cluster found in the soil ...
Zongqiang Wang, Nicholas Forelli, Yozen Hernandez, Melinda Ternei, Sean F. Brady   +4 more
doaj   +1 more source

Topoisomerase IIα promotes activation of RNA polymerase I transcription by facilitating pre-initiation complex formation [PDF]

, 2013
Type II DNA topoisomerases catalyse DNA double-strand cleavage, passage and re-ligation to effect topological changes. There is considerable interest in elucidating topoisomerase II roles, particularly as these proteins are targets for anti-cancer drugs.
Porter, Andrew C. G., Panov, Konstantin I; id_orcid, Zomerdijk, Joost C.B.M., Russell, J., Miller, G. (Gail), Zomerdijk, Joost C B M, Porter, A.C., Porter, Andrew C G, Volkov, A., Panov, K.I., Panov, Konstantin I., Russell, J. (Jackie), Panova, T., Zomerdijk, J.C., Miller, Gail, Porter, Andrew C.G., Miller, G., Panova, Tatiana, Russell, Jackie, Ray, S., Ray, Swagat, Volkov, Arsen, Zomerdijk, Joost C. B. M.   +22 more
core   +1 more source

Role of Topoisomerase IIβ in DNA Damage Response following IR and Etoposide

Journal of Nucleic Acids, 2010
The role of topoisomerase IIβ was investigated in cell lines exposed to two DNA damaging agents, ionising radiation (IR) or etoposide, a drug which acts on topoisomerase II. The appearance and resolution of γH2AX foci in murine embryonic fibroblast cell
Nicola J. Sunter, Ian G. Cowell, Elaine Willmore, Gary P. Watters, Caroline A. Austin   +4 more
doaj   +1 more source

Clerocidin interacts with the cleavage complex of Streptococcus pneumoniae topoisomerase IV to induce selective irreversible DNA damage [PDF]

, 2006
Clerocidin (CL), a diterpenoid natural product, alkylates DNA through its epoxide moiety and exhibits both anticancer and antibacterial activities. We have examined CLaction in the presence of topoisomerase IV from Streptococcus pneumoniae.
Fisher, LM, RICHTER, SARA, Giaretta, G, LEO, ELISABETTA, GIARETTA, GIULIA, Palumbo, M, Leo, E, FISHER L. M, Richter, SN, Gatto, B, GATTO, BARBARA, PALUMBO, MANLIO   +11 more
core   +1 more source

The topoisomerase II inhibitor voreloxin causes cell cycle arrest and apoptosis in myeloid leukemia cells and acts in synergy with cytarabine

Haematologica, 2011
Background Topoisomerase II is essential for the maintenance of DNA integrity and the survival of proliferating cells. Topoisomerase II poisons, including etoposide and doxorubicin, inhibit enzyme-mediated DNA ligation causing the accumulation of double ...
Elisabeth J. Walsby, Steven J. Coles, Steven Knapper, Alan K. Burnett   +3 more
doaj   +1 more source

Plasmodium Topoisomerase VIB and Spo11 Constitute Functional Type IIB Topoisomerase in Malaria Parasite: Its Possible Role in Mitochondrial DNA Segregation

Microbiology Spectrum, 2023
The human malaria parasite undergoes a noncanonical cell division, namely, endoreduplication, where several rounds of nuclear, mitochondrial, and apicoplast replication occur without cytoplasmic division. Despite its importance in Plasmodium biology, the
Priyanka Singh, Wahida Tabassum, Nupur Fangaria, Sandeep Dey, Siladitya Padhi, Mrinal K. Bhattacharyya, Kota Arun Kumar, Arijit Roy, Sunanda Bhattacharyya   +8 more
doaj   +1 more source

Differential regulation of NF-κB activation and function by topoisomerase II inhibitors

BMC Cancer, 2006
Background While many common chemotherapeutic drugs and other inducers of DNA-damage result in both NF-κB nuclear translocation and DNA-binding, we have previously observed that, depending on the precise stimulus, there is great diversity of the function
Perkins Neil D, O'Shea John M, Campbell Kirsteen J   +2 more
doaj   +1 more source