Results 121 to 130 of about 29,245 (221)

Systemic anti‐cancer therapy associated with the occurrence of peripheral neurotoxicity and, specifically, peripheral neuropathy

International Journal of Cancer, Volume 159, Issue 2, Page 460-466, 15 July 2026.
What's new? While the effectiveness of systemic anticancer therapy is well documented, it commonly causes severe toxicity. This study of the 467 systemic anticancer therapy agents currently approved globally for clinical and/or research purposes found that peripheral neurotoxicity is associated with 45% of classical chemotherapies, 21% of targeted ...
Cassie Higgins, Lynn R. Gauthier, Blair H. Smith, Lesley Colvin   +3 more
wiley   +1 more source

Immunomodulatory Potential of Quinoline Q3, a Selective Inhibitor of the Canonical NF‐κB Pathway in Macrophages

ChemMedChem, Volume 21, Issue 13, 14 July 2026.
The quinolone Q3 specifically enhances the DNA binding of the p50/p50 NF‐κB dimers, while inhibiting the activity of the p65 transcriptional activator, resulting in inhibition of the NF‐κB canonical pathway in lipopolysaccharide (LPS)‐stimulated macrophages.
Konstantinos Michail, Panagiotis Ntavaroukas, Vasiliki Petriki, Evangelos Tsioupros, Stella Manta, Barry J. Campbell, Stamatia Papoutsopoulou   +6 more
wiley   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, Volume 20, Issue 7, Page 1857-1876, July 2026.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Mechanically Triggered DNA Nanovehicles for Targeted Dual‐Drug Cancer Therapy

Advanced Science, Volume 13, Issue 39, 13 July 2026.
A mechanically triggered DNA nanovehicle is introduced that co‐releases two anticancer drugs in response to integrin‐mediated cellular forces. Cholesterol‐anchored DNA assemblies undergo force‐induced unfolding at cell–cell junctions, enabling selective, localized dual‐drug activation in cancer cells while minimizing off‐target toxicity in low‐tension ...
Murali Mohana Rao Singuru, Priyanka Bhattacharyya, Mingxu You   +2 more
wiley   +1 more source

Photodynamic Priming and Minocycline Overcome Chemoresistance by Reprogramming the Pancreatic Tumor Immune Microenvironment In Vivo

Advanced Science, Volume 13, Issue 38, 9 July 2026.
Dual priming with minocycline and photodynamic priming reprograms the pancreatic tumor microenvironment to overcome chemoresistance. By suppressing DNA repair enzyme Tdp1, inducing photooxidative damage, and enhancing irinotecan delivery via light‐activated nanoencapsulation, this strategy remodels the tumor microenvironment and drives immune ...
Fernanda V. Cabral, Jose Quilez‐Alburquerque, Olivia Mooradian, Shivendran Vytheswarran, Badri Parshad, Girgis Obaid, Huang‐Chiao Huang, Tayyaba Hasan   +7 more
wiley   +1 more source

Primary cilia–extracellular vesicle crosstalk in Alzheimer's disease: Emerging mechanisms and biomarker potential

Alzheimer's &Dementia, Volume 22, Issue 7, July 2026.
Abstract Alzheimer's disease (AD) is a neurodegenerative condition marked by cognitive decline and synaptic issues. Recent studies show primary cilia (PCs), sensory organelles present on the surface of most mammalian cells, act as a critical regulators of brain homeostasis and signaling.
Vishal Singh Guleria, Charisse N. Winston   +1 more
wiley   +1 more source

Duocarmycin‐Bearing Antibody‐Mimetic Drug Conjugate Combined With an ATR Inhibitor Results in Complete Tumor Regression in a KPL‐4 Xenograft Model

Cancer Medicine, Volume 15, Issue 7, July 2026.
ABSTRACT Antibody–drug conjugates (ADCs) have demonstrated superior clinical outcomes in patients with HER2‐positive advanced breast cancer compared with previous treatment modalities. However, resistance and treatment‐limiting toxicities frequently emerge during repeated administration, underscoring an unmet need for strategies to overcome ADC failure.
Toshiya Tanaka, Akira Sugiyama, Juri Sakata, Toshifumi Tatsumi, Hiroto Katoh, Keisuke Maeda, Yuya Inagaki, Takefumi Yamashita, Takeshi Kawamura, Mayu Kuratani, Taiki Nakano, Masazumi Ishii, Mai Miura, Wakana Kamiya, Yuko Shiratori, Hisato Kitanoya, Michael Chansler, Naoki Harada, Masayuki Tsuchiya, Tsuyoshi Osawa, Shumpei Ishikawa, Tatsuhiko Kodama, Kenzo Yamatsugu, Hidetoshi Tokuyama, Motomu Kanai   +24 more
wiley   +1 more source

Insights into podophyllotoxin lactone features: New cyclolignans as potential dual tubulin-topoisomerase II inhibitors. [PDF]

Arch Pharm (Weinheim)
Hernández ÁP, Rosales-Fernández C, Miranda-Vera C, Veselinova A, Jambrina PG, García-García P, García PA, Díez D, Castro MÁ, Fuentes M.   +9 more
europepmc   +1 more source

Chemo‐Immunotherapy, a Combination Approach for the Treatment of HER2‐Positive Breast Cancer in a Mouse Model

Cancer Medicine, Volume 15, Issue 7, July 2026.
Experimental workflow of HER2/Neu‐targeted dendritic cell‐based chemo‐immunotherapy in a 4T1‐HER2 breast cancer xenograft model. ABSTRACT The discovery of tumor‐associated antigens has been a significant milestone for cancer therapy as the current conventional therapies (radiotherapy, chemotherapy) were found to be insufficient in terms of cancer ...
Cenk Serhan Özverel, Kubilay Doğan Kılıç, Yiğit Uyanikgil, İsmail Karaboz, Ayse Nalbantsoy   +4 more
wiley   +1 more source

Metronomic Chemotherapy in Ovarian Cancer: Current Scenario and AI‐Integrated Future Strategies

Cancer Reports, Volume 9, Issue 7, July 2026.
ABSTRACT Background Ovarian cancer (OC) is a globally prevalent malignancy associated with a high mortality rate and marked biological heterogeneity, with most cases arising from epithelial cells and presenting as serous, endometrioid, or clear cell subtypes.
Ravi Chauhan, Suraja Kumar Das, Lakshay Malhotra, Rajeev Goyal, Sameer Mirza, Khushi Nehra, Maysaloun Merhi, Ammira S. Al‐Shabeeb Akil, Shahab Uddin, Shweta Tripathi, Ajaz A. Bhat, Mayank Singh   +11 more
wiley   +1 more source