Results 141 to 150 of about 29,245 (221)

Optimisation of a Novel Class of DNA Gyrase Inhibitors to Improve Antibacterial Activity

ChemMedChem, Volume 21, Issue 11, 15 June 2026.
This article describes efforts to increase the antibacterial activity of a recently reported class of novel DNA gyrase inhibitors known as the isoquinoline sulphonamides by improving their uptake in bacterial cells. As antibiotic resistance continues to rise, the need for new antibacterials is clear.
Meg I. Ferguson, Cerissa C. van Walstijn, Vladyslav Lysenko, Marta A. Wilbrink, David Alencar Araripe, Jeroen M. Punt, Mario van der Stelt, Willem Jespers, Paolo Innocenti, Nathaniel I. Martin   +9 more
wiley   +1 more source

Topoisomerase-II Inhibitor Racemic XK469 [PDF]

, 2020
openaire   +1 more source

Rezatapopt and the Return of Targetable p53

MedComm, Volume 7, Issue 7, July 2026.
Yuanze Luo, Assam El‐Osta
wiley   +1 more source

Treatment of acquired drug resistance in multiple myeloma by combination therapy with XPO1 and topoisomerase II inhibitors. [PDF]

J Hematol Oncol, 2016
Turner JG, Dawson JL, Grant S, Shain KH, Dalton WS, Dai Y, Meads M, Baz R, Kauffman M, Shacham S, Sullivan DM.   +10 more
europepmc   +1 more source

PAF1c depletion confers chemoresistance to topoisomerase inhibitors. [PDF]

Cell Insight
Li D, Zhu C, Wang T, Chen Q, Chen Q.
europepmc   +1 more source

Characterization of Alternaria alternata alternariol monomethyl ether with a potential antiproliferative activity by topoisomerases inhibition; molecular docking and dynamic simulations. [PDF]

Sci Rep
El-Sayed ASA, Aboelez MO, Ezelarab HAA, Ewedah TM, El-Baz AF, Ashraf R, Diab A, Safwat G, Rady AM, El-Mekkawy RM.   +9 more
europepmc   +1 more source

HIF inhibition: Current strategies and clinical challenges. [PDF]

Redox Biol
Więch-Walów A, Bartoszewska S, Barton A, Czechowicz P, Dudzik J, Wielockx B, Collawn JF, Bartoszewski R.   +7 more
europepmc   +1 more source

Topoisomerase II Inhibitors Induce DNA Damage-Dependent Interferon Responses Circumventing Ebola Virus Immune Evasion. [PDF]

mBio, 2017
Luthra P, Aguirre S, Yen BC, Pietzsch CA, Sanchez-Aparicio MT, Tigabu B, Morlock LK, García-Sastre A, Leung DW, Williams NS, Fernandez-Sesma A, Bukreyev A, Basler CF.   +12 more
europepmc   +1 more source

Structure-Based Drug Design Targeting Topoisomerase II Alpha: Discovery of Potential Antitumor Xanthone Derivatives. [PDF]

Molecules
Le TTH, Nguyen TNH, Pham MQ, Tran TTT, Dinh TT, Tran THV, Tran VL, Pham QL.   +7 more
europepmc   +1 more source

Antibody-Drug Conjugates: Pharmacotherapeutic Properties and Future Perspectives. [PDF]

Pharmaceutics
Augusto A, Cristiano MLS, Conceição J.
europepmc   +1 more source