Results 81 to 90 of about 29,245 (221)

Bevacizumab‐Associated Eczema Herpeticum in Metastatic Ovarian Carcinoma: A Case Report

JEADV Clinical Practice, EarlyView.
ABSTRACT Eczema herpeticum (EH) is a rare but potentially life‐threatening cutaneous infection caused by herpes simplex virus (HSV), classically associated with atopic dermatitis. Its occurrence in oncology patients receiving anti‐angiogenic targeted therapy and cytotoxic chemotherapy is exceedingly uncommon.
Mandeep Dutta Joshi, Nishant Pandey, Sushan Ghimire, Avilasha Shah, Anurag Tiwari, Salina Subedi, Deepika Neupane   +6 more
wiley   +1 more source

DNA topoisomerase inhibitors: biflavonoids from Ouratea species

Brazilian Journal of Medical and Biological Research, 2002
Topoisomerase inhibitors are agents with anticancer activity. 7"-O-Methyl-agathisflavone (I) and amentoflavone (II) are biflavonoids and were isolated from the Brazilian plants Ouratea hexasperma and O. semiserrata, respectively.
N.F. Grynberg, M.G. Carvalho, J.R. Velandia, M.C. Oliveira, I.C. Moreira, R. Braz- Filho, A. Echevarria   +6 more
doaj   +1 more source

Aliphatic Poly(Carbonate)s with Acid Responsive Release Mechanisms for Micellar Anti‐Tumor Drug Delivery

Macromolecular Rapid Communications, EarlyView.
Micellar systems based on biodegradable aliphatic polycarbonates and acid‐responsive triggers enhance drug solubility, stability, and tumor‐selective release. This review covers micelles with acid‐cleavable drug linkages and those that disassemble via acid‐sensitive functionalities.
Adrian V. Hauck, Lutz Nuhn
wiley   +1 more source

Universal and Lineage‐Specific Patterns in the Distribution of ECOD Domain Homology Groups Across Superkingdoms

Proteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT Proteins are built from modular domains that serve as fundamental units of structure and evolution. While individual domains have been extensively cataloged, their collective distribution across the lineages of life has remained poorly resolved.
Rui Guo, Jimin Pei, Jing Zhang, Qian Cong, Nick V. Grishin, R. Dustin Schaeffer   +5 more
wiley   +1 more source

Nicotinonitrile based dual inhibitors of tubulin and topoisomerase II exhibit potent anticancer activity

Scientific Reports
A series of 2,4,6-trisubstituted nicotinonitriles, compounds 10–41, was designed as pyridine bridged analogs of combretastatin A4 and evaluated as dual inhibitors of topoisomerase II and tubulin polymerization.
Eman S. Hassan, Abdalla E. A. Hassan, Shaikha S. Al Neyadi, Yasir S. Raouf, Hanem M. Awad, Zakaria K. M. Abdel-Samii, Amany M. M. Al-Mahmoudy, Reham A I. Abou-Elkhair   +7 more
doaj   +1 more source

DNA-Dependent Protein Kinase Inhibitor Peposertib Potentiates the Cytotoxicity of Topoisomerase II Inhibitors in Synovial Sarcoma Models. [PDF]

Cancers (Basel), 2023
Revia S, Budzinska MA, Bogatyrova O, Neumann F, Zimmermann A, Amendt C, Albers J.   +6 more
europepmc   +1 more source

A lysosome‐targeted ultra‐sensitive viscosity probe for monitoring viscosity alterations during chemotherapy

Smart Molecules, EarlyView.
A novel chemosensing platform based on a molecular rotor architecture is established for specific, dynamic detection of lysosomal viscosity. The platform allows real‐time tracking of lysosomal viscosity fluctuations induced by various chemotherapeutic agents, highlighting its significant potential as a powerful tool for early cancer diagnostics and ...
Haoyang Song, Hui Bian, Lei Liu, Gahyeon Park, Bingqing Sun, Qiongzheng Hu, Juyoung Yoon   +6 more
wiley   +1 more source

Deciphering diverse cell‐death patterns to predict the prognosis and potential therapy target of hepatocellular carcinoma patients

VIEW, EarlyView.
Abstract Ninety percent of all primary liver malignancies are hepatocellular carcinomas (HCC), making liver cancer the third most common cause of cancer‐associated mortality. Different patterns of programmed cell death (PCD) are crucial for the survival of tumors, and they might serve as a prognostic marker for HCC.
Lin Ding, Qian Li, Wenjing Yang, Te Liu, Tongtong Tian, Yu Liu, Chunyan Zhang, Baishen Pan, Beili Wang, Fan Wu, Wei Guo   +10 more
wiley   +1 more source

Investigating the potential anticancer activities of antibiotics as topoisomerase II inhibitors and DNA intercalators: in vitro, molecular docking, molecular dynamics, and SAR studies. [PDF]

J Enzyme Inhib Med Chem, 2023
Farouk F, Elmaaty AA, Elkamhawy A, Tawfik HO, Alnajjar R, Abourehab MAS, Saleh MA, Eldehna WM, Al-Karmalawy AA.   +8 more
europepmc   +1 more source

Telangiectasia in Systemic Sclerosis Is a Marker of Increased Disease Morbidity and Mortality: Analyses From the Australian Scleroderma Cohort Study

Australasian Journal of Dermatology, EarlyView.
ABSTRACT This Australian retrospective cohort analysis of 1977 patients investigates and expands on correlates of telangiectasia in systemic sclerosis to determine whether this cutaneous sign is a potential surrogate marker for disease progression and prognosis.
Vivien Wai Yun Lai, Dylan Hansen, Maryam Tabesh, Jessica Fairley, Laura Ross, Nava Ferdowsi, Gene‐Siew Ngian, Diane Apostolopoulos, Joanne Sahhar, Lauren V. Host, Jennifer Walker, Gabor Major, Susanna Proudman, Wendy Stevens, Mandana Nikpour, Amanda M. Saracino   +15 more
wiley   +1 more source