Results 111 to 120 of about 4,050,496 (258)

Lactate‐H3K18la‐RPL11 Axis Drives Gemcitabine Resistance in Pancreatic Cancer by Integrating Protein Synthesis and DNA Damage Repair

Advanced Science, EarlyView.
A lactate‐H3K18la epigenetic axis upregulates RPL11 to drive gemcitabine resistance in pancreatic cancer. RPL11 orchestrates chemoresistance through a dual, compartmentalized role: enhancing cytoplasmic protein synthesis via EEF1A1 stabilization and promoting nuclear DNA damage repair by co‐activating PARP14, thus ensuring robust cell survival ...
Lijun Zhao, Jianzhong Cao, Wenyue Liu, Xuyun Li, Haolin Zhang, Xiaofang Zhang, Shiyang Shi, Huilong Yin, Junjie Li, Angang Yang, Rui Zhang   +10 more
wiley   +1 more source

UBE3A Dosage Imbalance as a Molecular Framework Linking Angelman Syndrome and Dup15q‐Associated Autism Phenotypes

American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, EarlyView.
ABSTRACT UBE3A is a dosage‐sensitive HECT E3 ubiquitin ligase whose neuronal expression is shaped by genomic imprinting at the 15q11.2‐q13 locus. Opposite directions of UBE3A dosage imbalance contribute to distinct neurodevelopmental phenotypes: loss of maternal UBE3A underlies Angelman syndrome, whereas maternally derived 15q11.2‐q13 copy‐number gains,
Ruslan Kurmashev
wiley   +1 more source

Dataset from Patulin and Xestoquinol are inhibitors of DNA topoisomerase 1

Numerical data used to generate graphs in the manuscript "Patulin and Xestoquinol are inhibitors of DNA topoisomerase 1"Peer ...
Losada, Alejandro, Wellinger, Ralf Erik, Herrera-Moyano, Emilia, Salas-Lloret, Daniel, Gaillard, Hélène, Tumini, Emanuela, Aguilera, Andrés, García-Rubio, María, Luna, Rosa, Navarro-Cansino, Patricia, Muñoz-Alonso, María J.   +10 more
core   +1 more source

Structures of representative HDAC and topoisomerase I inhibitors.

, 2018
Structures of representative HDAC and topoisomerase I inhibitors.
Raffaella Cincinelli (192154), Loana Musso (2397487), Claudio Pisano (192167), Francesco Cardile (5832497), Martina Frusciante (5832500), Roberto Artali (390573), Ilaria La Porta (5832491), Mario B. Guglielmi (1828249), Carmela Melito (5832494), Sabrina Dallavalle (553424), Fabiana Colelli (849197), Giacomo Signorino (462499), Alessandra Fucci (235943)   +12 more
core   +1 more source

Benzothiazole derivatives as human DNA topoisomerase IIα inhibitors [PDF]

, 2020
Benzothiazole derivatives resembling the structure of DNA purine bases were tested to determine their topoisomerase inhibition activities. Based on DNA topoisomerase I and II relaxation assay results, all 12 derivatives acted as human topoisomerase IIa ...
Cigdem Kaplan-Ozen, Ilkay Yildiz, Nuran Diril, Esin Aki, Betul Tekiner-Gulbas, Ismail Yalcin, Egemen Foto   +6 more
core  

Discovery of Novel Topoisomerase II Inhibitors by Medicinal Chemistry Approaches.

Journal of Medicinal Chemistry, 2018
DNA topoisomerase II (topo II) is an important enzyme involved in DNA replication, recombination, and repair. Despite the popular applications of topo II inhibitors in cancer therapy, there is still an urgent need to upgrade topo II inhibitors to cope ...
Wei Hu, Xu-Sheng Huang, Ji-feng Wu, Liang Yang, Yong-Tang Zheng, Yue-Mao Shen, Zhiyuan Li, Xun Li   +7 more
semanticscholar   +1 more source

Activation of Metal Complexes With Ultrasound Waves for Targeted Anticancer Therapy

Angewandte Chemie International Edition, EarlyView.
Ultrasound enables non‐invasive activation of metal‐based therapeutics deep within tumors. Acoustic cavitation can drive sonodynamic reactive oxygen species generation or mechanochemical metal–ligand bond dissociation, enabling controlled release of bioactive payloads.
Félix Grosjean, Nicolás Montesdeoca, Gilles Berger, Johannes Karges   +3 more
wiley   +1 more source

Integrating One Health to Mitigate the Emergence and Spread of Antimicrobial Resistance in Livestock and Aquaculture

Animal Research and One Health, EarlyView.
Antimicrobial resistance (AMR) is an escalating global threat driven by antimicrobial use in aquaculture and livestock. Resistant pathogens and genes can spread across humans, animals, and the environment through interconnected ecosystems. Using a One Health approach, this review emphasizes antimicrobial stewardship, regulatory strengthening, enhanced ...
Mir Mohammad Ali, Delower Hossain, Ridwan Olamilekan Adesola, Anum Hanif, Shamsaldeen Ibrahim Saeed, Muhammad Abdul Mannan, Anoar Jamai Masroure, Kazi Estieque Alam, Md Kamal Hossain, Sabiha Zarin Tasnim Bristi, Md Jisan Ahmed   +10 more
wiley   +1 more source

Discovery of New DNA Topoisomerase II Inhibitors using Structure Based Virtual Screening Method

Journal of the Turkish Chemical Society, Section A: Chemistry, 2019
DNA topoisomerases are proved therapeutic targets of anticancer and antibacterial drugs. Structures of topoisomerase–DNA and inhibitor ternary complexes have revealed the exact binding sites and mechanisms of topoisomerase poisons. There are two isoforms
Tugba Ertan-Bolelli, Kayhan Bolelli
doaj   +1 more source

The Effect of Topoisomerase I Inhibitors on the Efficacy of T-Cell-Based Cancer Immunotherapy

Journal of the National Cancer Institute, 2017
Background Immunotherapy has increasingly become a staple in cancer treatment. However, substantial limitations in the durability of response highlight the need for more rational therapeutic combinations.
Jodi A. McKenzie, Rina M Mbofung, Shruti Malu, Min Zhang, Emily L Ashkin, S. Devi, Leila J. Williams, T. Tieu, Weiyi Peng, S. Pradeep, Chunyu Xu, Soraya Zorro Manrique, Chengwen Liu, Lu Huang, Yuan Chen, M. Forget, C. Haymaker, C. Bernatchez, Nikunj Satani, F. Muller, J. Roszik, A. Kalra, T. Heffernan, A. Sood, Jianhua Hu, R. Amaria, R. E. Davis, P. Hwu   +27 more
semanticscholar   +1 more source