Results 151 to 160 of about 67,641 (348)

Deciphering diverse cell‐death patterns to predict the prognosis and potential therapy target of hepatocellular carcinoma patients

VIEW, EarlyView.
Abstract Ninety percent of all primary liver malignancies are hepatocellular carcinomas (HCC), making liver cancer the third most common cause of cancer‐associated mortality. Different patterns of programmed cell death (PCD) are crucial for the survival of tumors, and they might serve as a prognostic marker for HCC.
Lin Ding, Qian Li, Wenjing Yang, Te Liu, Tongtong Tian, Yu Liu, Chunyan Zhang, Baishen Pan, Beili Wang, Fan Wu, Wei Guo   +10 more
wiley   +1 more source

Topoisomerases

, 1998
Capítulo en: Ram S. Verma (ed.). Advances in Genome Biology, vol. 5B. [S.l.]: JAI Press, 1998, p.463-486. ISBN 0-7623-0079-5. ISBN 978-0-7623-0079-2 This chapter describes topoisomerases. Much progress has been made in structural and functional studies on DNA topoisomerases.
openaire   +2 more sources

ChitoSilkBioPatch: A bio‐inspired wound dressing scaffold for antibiotic‐free diabetic wound management

VIEW, EarlyView.
We present ChitoSilkBioPatch, a maleimide‐functionalized chitosan/dACM hydrogel integrated with a stretchable nanopatterned silk mesh to provide intrinsic, antibiotic‐free antibacterial activity and bioactive wound support. The scaffold eliminates S. aureus and P.
Dorsa Dehghan‐Baniani, Babak Mehrjou, Yucong Li, Zhaowei Jiang, Xiaomin Lu, Yin Xiao, Huanxiong Chen, Tsz Lam Yiu, Chi Chiu Wang, Hongkai Wu, Gang Li, Paul K. Chu, Wayne Yuk Wai Lee   +12 more
wiley   +1 more source

The Implication of Topoisomerase II Inhibitors in Synthetic Lethality for Cancer Therapy [PDF]

, 2023
Victor M. Matias-Barrios, Xuesen Dong
openalex   +1 more source

Integrated multi‐omics analysis reveals metabolic reprogramming as a key driver of angiotensin II‐induced vascular remodeling

VIEW, EarlyView.
This study investigates the molecular alterations underlying angiotensin II (Ang II)‐induced vascular remodeling in cardiovascular diseases using a multi‐omics approach. Through data exploration and integrated multi‐omics analysis, our findings reveal that Ang II‐driven vascular injury in vascular smooth muscle cells is mediated by metabolic ...
Yiwei Hu, Dan Zhao, Lingyan Zhong, Jianxujie Zheng, Dongxue Zhang, Enhui Wu, Qian Shi, Liang Qiao, Ling Lin   +8 more
wiley   +1 more source

A Topoisomerase II-Dependent Checkpoint in G2-Phase Plant Cells Can Be Bypassed by Ectopic Expression of Mitotic Cyclin B2 [PDF]

, 2002
Juan F. Giménez-Abián, Magdalena Weingartner, Pavla Binarová, Duncan J. Clarke, Richard G. Anthony, Ornella Calderini, Erwin Heberle‐Bors, Susana Moreno Dı́az de la Espina, Díaz de la Espina, László Bögre, Consuelo de la Torre   +10 more
openalex   +1 more source

Super-resolution microscopy reveals the number and distribution of topoisomerase IIα and CENH3 molecules within barley metaphase chromosomes [PDF]

, 2023
Ivona Kubalová, Klaus Weißhart, Andreas Houben, Veit Schubert   +3 more
openalex   +1 more source

Trastuzumab Deruxtecan for HER2‐Low Metastatic Breast Cancer: Practical Considerations for Medical Oncologists and Pathologists in Australia

Asia-Pacific Journal of Clinical Oncology, EarlyView.
ABSTRACT Trastuzumab deruxtecan (T‐DXd) is a third‐generation, HER2‐targeting antibody‐drug conjugate that has been shown to significantly prolong overall survival, compared with standard chemotherapy, when used to treat patients who have “HER2‐low” (HER2 immunohistochemistry [IHC] score 1+; or HER2 IHC 2+ plus in situ hybridization‐negative ...
Andrew Redfern, Elgene Lim, Sunil Lakhani, Nirmala Pathmanathan, Sudarsha Selva‐Nayagam, Nicole McCarthy, Belinda Yeo, Benjamin Dessauvagie, Gelareh Farshid   +8 more
wiley   +1 more source

Hypomethylating agents in vacuoles, E1 enzyme, X‐linked, autoinflammatory, somatic syndrome (VEXAS): A systematic review

British Journal of Haematology, EarlyView.
Summary VEXAS syndrome (vacuoles, E1 enzyme, X‐linked, autoinflammatory, somatic) is an X‐linked, systemic, haemato‐inflammatory syndrome caused by somatic mutations in the UBA1 gene. No standardized treatment guidelines exist, but evidence is emerging that treatment with hypomethylating agents (HMAs) can induce improvement of the inflammatory symptoms,
Fieke W. Hoff, Roochi Trikha, Emma M. Groarke, Bhavisha A. Patel   +3 more
wiley   +1 more source

Balanced translocations involving chromosome bands 11q23 and 21q22 are highly characteristic of myelodysplasia and leukemia following therapy with cytostatic agents targeting at DNA-topoisomerase II [letter] [PDF]

, 1991
J Pedersen-Bjergaard, P Philip
openalex   +1 more source