Results 131 to 140 of about 23,598 (268)

Single‐cell transcriptional consequences of leukaemogenic SETBP1 mutations

British Journal of Haematology, EarlyView.
Mi K. Trinh, Nathaniel D. Anderson, Matthew D. Young, Holly J. Whitfield, Conor Parks, Toochi Ogbonnah, Agnes Oszlanczi, Di Zhou, Emilia R. Robertson, Angus Hodder, Rebecca Thomas, Karin Straathof, Stuart Adams, Jack Bartram, Nuala Summerfield, Sam Behjati   +15 more
wiley   +1 more source

Human‐derived cardiac‐neural microtissues reveal catecholaminergic polymorphic ventricular tachycardia is also a disease of the sympathetic neuron

The Journal of Physiology, EarlyView.
Abstract figure legend Schematic diagram illustrating the proposed pathway in which regulatory defects might occur in sympathetic neurons derived from hiPSC in catecholaminergic polymorphic ventricular tachycardia (CPVT). Specifically, enhanced calcium transients appeared to derive from three sources: enhanced membrane excitability (due to loss of ...
Ni Li, Chenchen Zhang, Mengying Xu, YoonYoung Choi, Davi Sidarta‐Oliveira, Ruirui Dong, Xinyu Hu, Enrique M. Toledo, Cesar A. Prada‐Medina, Finbar Argus, Kun Liu, Mingyu Li, Linna Zhou, Hagan Bayley, Corey Smith, Chris Denning, Ana I. Domingos, Guoliang Hao, Dan Li, David J. Paterson   +19 more
wiley   +1 more source

Synergistic Effects of IMP‐1700, Ciprofloxacin, and X‐Ray Radiation in Bacteria and Mammalian Cell Lines: Implications for Use in Antimicrobial‐Resistant Bacteria

MicrobiologyOpen, Volume 15, Issue 3, June 2026.
IMP‐1700 enhances the cytotoxic effect on bacteria in combination with either ciprofloxacin (CPX) or X‐ray. In noncancerous and tumor cells, combination treatments markedly reduce viability with radiosensitizing effects. Further studies are needed to clarify the mechanism underlying IMP‐1700s effects on mammalian cells. Created in BioRender. Kjaer, A. (
Ida Vang Andersen, Ane Beth Sloth, Emilie Caroline Skuladottir Bøgestad, Christian Bernard Matthijs Poulie, Anne Skovsbo Clausen, Umberto Maria Battisti, Matthias M. Herth, Andreas Kjaer   +7 more
wiley   +1 more source

Colorectal Precancerous Lesions: Molecular Mechanisms, Research Tools, and Natural Product‐Based Clinical Translation

MedComm – Oncology, Volume 5, Issue 2, June 2026.
This article systematically elucidates the molecular mechanisms of colorectal precancerous lesions, introduces cutting‐edge research tools like multi‐omics and organoids, and highlights the potential and prospects of natural products such as berberine, resveratrol, and curcumin in preventing and intervening in colorectal carcinogenesis by modulating ...
Shunji Liu, Chujuan Cui, Lingdong Kong, Qiang Xu, Haibo Cheng, Lisha Zhou, Yang Sun   +6 more
wiley   +1 more source

Targeting EZH2 in Cancer: From Molecular Mechanisms to Clinical Translation

MedComm – Oncology, Volume 5, Issue 2, June 2026.
The abnormal overexpression or gain‐of‐function mutations of EZH2 play a significant role in cancer occurrence and progression, highlighting the importance and potential of EZH2 as a cancer biomarker. Therefore, screening for effective and safe small‐molecule inhibitors, degraders, and natural compounds targeting EZH2 through preclinical cancer models ...
Xi Zhong, Jieni Li, Mingxuan Pan, Xiaoxue Ke, Hongjuan Cui   +4 more
wiley   +1 more source

Chromosome segregation in a minimal bacterial cell driven by SMC protein complexes

Protein Science, Volume 35, Issue 6, June 2026.
Abstract Minimal bacterial cells such as JCVI‐Syn3A provide a powerful system for uncovering the essential mechanisms of chromosome organization and segregation. Lacking canonical systems such as Min and ParABS, JCVI‐Syn3A relies primarily on structural maintenance of chromosomes (SMC) protein complexes for partitioning.
Andrew K. Maytin, Benjamin R. Gilbert, Zaida Luthey‐Schulten   +2 more
wiley   +1 more source

A Feasibility Study of the Repurposing of Prazosin to Improve Treatment Outcomes in Men Receiving Radiotherapy for Prostate Cancer (MiniRaP‐00)

The Prostate, Volume 86, Issue 8, Page 891-899, June 2026.
ABSTRACT Background Further work is needed to improve treatment outcomes for prostate cancer (PCa), with the repurposing of the α1‐adrenoreceptor antagonists presenting a potential solution. This feasibility clinical trial presents the first prospective data of the use of an α1‐adrenoreceptor antagonist in men undergoing radiotherapy for PCa.
Liam D. King, David Christie, Daniel Cehic, Wendy Dare, Russ Chess‐Williams, Donna Sellers, Catherine McDermott, Alexandra McCarthy, Shailendra Anoopkumar‐Dukie   +8 more
wiley   +1 more source

Pitfalls and missing links in current understanding of 4D genomes

Quantitative Biology, Volume 14, Issue 2, June 2026.
Abstract The spatial and temporal organization of the genome—collectively termed the 4D genome—is pivotal for regulating gene expression, maintaining genome stability, and guiding development. The convergence of chromosome conformation capture technologies, super‐resolution microscopy, and single‐cell epigenomics has transformed our understanding of ...
Michael Q. Zhang
wiley   +1 more source

Trastuzumab Deruxtecan for HER2‐Low Metastatic Breast Cancer: Practical Considerations for Medical Oncologists and Pathologists in Australia

Asia-Pacific Journal of Clinical Oncology, Volume 22, Issue 3, Page 381-391, June 2026.
ABSTRACT Trastuzumab deruxtecan (T‐DXd) is a third‐generation, HER2‐targeting antibody‐drug conjugate that has been shown to significantly prolong overall survival, compared with standard chemotherapy, when used to treat patients who have “HER2‐low” (HER2 immunohistochemistry [IHC] score 1+; or HER2 IHC 2+ plus in situ hybridization‐negative ...
Andrew Redfern, Elgene Lim, Sunil Lakhani, Nirmala Pathmanathan, Sudarsha Selva‐Nayagam, Nicole McCarthy, Belinda Yeo, Benjamin Dessauvagie, Gelareh Farshid   +8 more
wiley   +1 more source

Production Performance and Ameliorative Effects of Switchgrass on Severely Saline‐Alkali Land in Coastal Areas of China

GCB Bioenergy, Volume 18, Issue 6, June 2026.
Switchgrass cultivation sustained biomass production while rapidly improving soil structure and reducing salinity in coastal saline‐alkali soils. These changes reshaped microbial communities through environmental filtering, establishing plant‐soil‐microbe feedbacks that support both bioenergy production and ecological restoration.
Aoxiang Chang, Bowen Li, Runli Li, Ting Wu, Qiang Guo, Xincun Hou, Cui Li, Mei Zheng, Honggang Chen, Yu Sun, Jinku Song, Yuejun Ma, Chunqiang Xing, Xiuyun Wan, Jinliang Chen, Chunqiao Zhao, Xifeng Fan, Zhenyu Fan   +17 more
wiley   +1 more source