Results 221 to 230 of about 67,641 (348)

Anthracyclines as Topoisomerase II Poisons: From Early Studies to New Perspectives [PDF]

, 2018
Jessica Marinello, Maria Delcuratolo, Giovanni Capranico   +2 more
openalex   +1 more source

Determining Preclinical Safety of Aclarubicin in Pediatric Malignancies

Pediatric Blood &Cancer, Volume 73, Issue 2, February 2026.
ABSTRACT Background Anthracyclines are among the most effective chemotherapeutic agents used to treat pediatric malignancies. However, their clinical use is limited by dose‐dependent toxicities, particularly cardiotoxicity and secondary malignancies.
Darleen S. Tu, Aaron K. Olson, Kimberly S. Waggie, Nicolas M. Garcia, Virginia J. Hoglund, Stephanie I. Walter, Jenna R. Rosinski, Harini Sadeeshkumar, Radhika Patel, Erolcan Sayar, Michael C. Haffner, Lisa Maves, Jacques Neefjes, Jay F. Sarthy, Elizabeth R. Lawlor, Shireen S. Ganapathi   +15 more
wiley   +1 more source

Cladosporium cladosporioides, endophyte of Strelitzia nicolai, as a new producer of Alternariol monomethyl ether with a potential cytotoxic activity. [PDF]

Sci Rep
Farag NM, El-Sayed ASA, Fikry E, Tawfeek N, El-Shafae AM, El-Domiaty MM.   +5 more
europepmc   +1 more source

The dynamic interplay between DNA topoisomerases and DNA topology

Biophysical Reviews, 2016
Yeonee Seol, K. Neuman
semanticscholar   +1 more source

Effect of Testosterone Therapy on Cytochrome P450 3A and P‐Glycoprotein Activities Using Midazolam and Digoxin as Probe Substrates Among Transgender Adults

Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, Volume 46, Issue 2, February 2026.
ABSTRACT Background Gender‐affirming testosterone therapy is one part of the standard of care for more than 1 million transgender adults in the United States. Testosterone therapy may influence the activities of drug‐metabolizing enzymes and transporters, but knowledge about its effect on the pharmacokinetics of other medications is limited.
Michiko Hunter, Rene Coig, Linda Risler, Kristen K. Patton, Radhika R. Narla, Dina N. Greene, Alson K. Burke, Elizabeth Micks, Mary F. Hebert, Lauren R. Cirrincione   +9 more
wiley   +1 more source

Fluoroquinolone‐Associated Psychiatric and Ocular Adverse Events: A Disproportionality Analysis Using Real‐World Data From FAERS (2011–2024)

Pharmacology Research &Perspectives, Volume 14, Issue 1, February 2026.
This pharmacovigilance study identifies a wide range of rapid‐onset neuropsychiatric and ocular adverse effects linked to fluoroquinolones (FQ). Disproportionality analysis revealed a disproportionate reporting of suicidal ideation and visual impairment following FQ treatment, emphasizing the urgent need for cautious prescribing and strengthened safety
Hau‐Tak Chau, Ngan Pan Bennett Au
wiley   +1 more source

Differential effect of supercoiling on bacterial transcription in topological domains. [PDF]

PLoS Comput Biol
Goldberg B, Yehya N, Xiao J, Meyer S.
europepmc   +1 more source

A consensus sequence for cleavage by vertebrate DNA topoisomerase II

, 1988
Jeffrey R. Spitzner, Mark T. Muller
openalex   +2 more sources

Oncofetal HMGA2 attenuates genotoxic damage induced by topoisomerase II target compounds through the regulation of local DNA topology [PDF]

, 2019
Syed Moiz Ahmed, Peter Dröge
openalex   +1 more source

Gut Microbiome Dysbiosis is Associated With Human T‐Lymphotropic Virus Type 1 (HTLV‐1) Infection and Disease Progression to HTLV‐1‐Associated Myelopathy/Tropical Spastic Paraparesis: A Cross‐Sectional Study

Smart Medicine, Volume 5, Issue 1, February 2026.
We provide the first comprehensive analysis of changes in the gut bacteriome at different clinical stages of HTLV‐1 infection. HTLV‐1 infection is associated with a dysbiosis that includes reduced bacterial diversity and an inverted Firmicutes/Bacteroidetes ratio.
Lorena Abreu Fernandes, Ana Olivia de Souza, Youko Nukui, Rosa Maria Marcusso, Augusto César Penalva de Oliveira, Jorge Casseb, Patricia Bianca Clissa, Silas G. Villas‐Boas, Sabri Saeed Sanabani   +8 more
wiley   +1 more source