Results 201 to 210 of about 16,235 (248)

Glutamine Metabolism in Health and Diseases

MedComm, Volume 7, Issue 10, October 2026.
Glutamine metabolism acts as a metabolic hub connecting cellular stress adaptation, immune regulation, and disease development. Through regulating energy production, biosynthesis, redox balance, and nitrogen metabolism, glutamine supports cellular homeostasis under physiological and pathological conditions.
Yi Ding, Fan Tong, Jing Zeng, Chun‐Ping Cui   +3 more
wiley   +1 more source

Cladosporium cladosporioides, endophyte of Strelitzia nicolai, as a new producer of Alternariol monomethyl ether with a potential cytotoxic activity. [PDF]

Sci Rep
Farag NM, El-Sayed ASA, Fikry E, Tawfeek N, El-Shafae AM, El-Domiaty MM.   +5 more
europepmc   +1 more source

Universal and Lineage‐Specific Patterns in the Distribution of ECOD Domain Homology Groups Across Superkingdoms

Proteins: Structure, Function, and Bioinformatics, Volume 94, Issue 10, Page 1644-1657, October 2026.
ABSTRACT Proteins are built from modular domains that serve as fundamental units of structure and evolution. While individual domains have been extensively cataloged, their collective distribution across the lineages of life has remained poorly resolved.
Rui Guo, Jimin Pei, Jing Zhang, Qian Cong, Nick V. Grishin, R. Dustin Schaeffer   +5 more
wiley   +1 more source

Differential effect of supercoiling on bacterial transcription in topological domains. [PDF]

PLoS Comput Biol
Goldberg B, Yehya N, Xiao J, Meyer S.
europepmc   +1 more source

Mechanism‐Informed Pharmacotherapy Optimization and Deprescribing: A Redox–Mitochondrial Framework

Pharmacology Research &Perspectives, Volume 14, Issue 5, October 2026.
From cumulative drug burden to mitochondrial stress and functional decline. The graphical abstract summarizes the central concept of the review, illustrating how cumulative pharmacotherapy exposure may contribute to redox–mitochondrial stress and thereby reduce biological and functional resilience.
Boštjan Martinc
wiley   +1 more source

IID432, a parasite-selective topoisomerase II inhibitor, achieves rapid single-dose parasite clearance in a murine chronic Chagas model. [PDF]

Proc Natl Acad Sci U S A
Saldivia M, Jumani RS, Thomas B, Baxley GM, Sancheti J, Bullara D, Galarneau JR, Cheung H, Chen YL, DeAsis RS, Patra D, René O, Noeske J, Schenk AD, Deniston C, Thakore S, Luu C, Wartchow C, Koester DC, Francisco AF, Blais J, Jiricek J, Hollingsworth SA, Gable JE, Kelly JM, Hochberg N, Knutson CG, Lakshminarayana SB, Sarko C, Manjunatha UH, Osborne CS, Diagana TT, Rao SPS.   +32 more
europepmc   +1 more source

Phytochemicals as Multitarget Therapeutics in Pancreatic Cancer: Mechanisms, Clinical Evidence, and Translational Challenges

Phytotherapy Research, Volume 40, Issue 10, Page 5973-5987, October 2026.
Pancreatic cancer, particularly pancreatic ductal adenocarcinoma, is aggressive and often diagnosed late, making treatment challenging. This review highlights the potential of phytochemicals, such as curcumin and quercetin, as multitarget agents that influence key carcinogenic pathways. These compounds exhibit anticancer effects by inhibiting processes
Md. Rezaul Islam, Abdur Rauf, F. M. Shourav, Hanan A. Ogaly, Abdullah S. M. Aljohani, Waleed Al Abdulmonem, Kamala Badalova, Marcello Iriti   +7 more
wiley   +1 more source

Topological Regulation of the Mammalian Genome by Positive DNA Supercoiling

Singh AK, Altamirano-Pacheco L, Taing L, Dubois A, Navarro P.   +4 more
europepmc   +1 more source

Flavonoids as Dual Topoisomerase I and II Inhibitors: Mechanistic Insights and Emerging Anticancer Strategies. [PDF]

Chem Biodivers
Parua P, Bag S, Sisodiya D, Jana K, Ghosh A, Debnath B, Ghosh G, Rath G.   +7 more
europepmc   +1 more source

Doxorubicin and 4‐Hydroperoxycyclophosphamide Alter Mitochondrial Dynamics and miR‐34 Expression in Spermatogonia and Spermatocytes In Vitro

Basic &Clinical Pharmacology &Toxicology, Volume 139, Issue 4, October 2026.
ABSTRACT Doxorubicin (DOX) and cyclophosphamide (CP) are widely used chemotherapeutic agents with known gonadotoxic effects. Since miRNAs play a key role in the transcriptional regulation of spermatogenesis, they are suggested as biomarkers for male infertility.
Hülya Öztatlıcı, Mahmut Kemal Özbilgin, Rukiye Betül Çolaksel, Suna Karadeniz Saygılı, Mustafa Öztatlıcı   +4 more
wiley   +1 more source