Results 191 to 200 of about 16,235 (248)

Accelerating Primary Screening of USP8 Inhibitors from Drug Repurposing Databases with Tree‐Based Machine Learning

Advanced Intelligent Discovery, Volume 2, Issue 5, October 2026.
This study introduces a tree‐based machine learning approach to accelerate USP8 inhibitor discovery. The best‐performing model identified 100 high‐confidence repurposable compounds, half already approved or in clinical trials, and uncovered novel scaffolds not previously studied. These findings offer a solid foundation for rapid experimental follow‐up,
Yik Kwong Ng, Sharon Ai Er Lam, Wei Chun Lim, Hannah Hui Min Toh, Shi Jun Ang   +4 more
wiley   +1 more source

Networked salt-bridges mediate magnesium-dependent conformational dynamics and functional regulation in type IA topoisomerases. [PDF]

Nat Commun
Seol Y, Tse-Dinh YC, Neuman KC.
europepmc   +1 more source

Developmental Toxicity Study for the Antimalarial Drug Combination Cabamiquine‐Pyronaridine Using a Translational Approach

Birth Defects Research, Volume 118, Issue 10, October 2026.
ABSTRACT Background The safety of pharmacological treatments during pregnancy is a significant concern, as many medications lack comprehensive reproductive safety data. This creates gaps in therapeutic options for pregnant women, particularly malaria, which poses serious risks to maternal and fetal health.
Wookyung Kim, Geum‐Sil Cho, Andreas Gado, Tobias Hyun Ho Baeurle, Habib Karimi, Filippo Venezia, Claude Oeuvray, Thomas Spangenberg, Sebastian G. Wicha, Claudia Demarta‐Gatsi   +9 more
wiley   +1 more source

Processing of DNA Topoisomerase II-DNA-Protein Crosslinks Associated With Anticancer Drugs. [PDF]

Genes Cells
Sakasai R, Iwabuchi K.
europepmc   +1 more source

Extracellularly Activatable Conjugates of RGD Peptidomimetics and Cryptophycin for αVβ3‐Targeted Cancer Therapy

Chemistry – A European Journal, Volume 32, Issue 37, 1 October 2026.
Integrin αVβ3‐targeting small‐molecule drug conjugates (SMDCs) were synthesized by conjugating a cryptophycin payload through a neutrophil elastase‐cleavable NPV‐PABC linker. RGD peptidomimetic and linker epimers served as controls for targeting and enzymatic cleavage, and the resulting conjugates displayed subnanomolar cytotoxicity in vitro.
Dominic Seißenschmidt, Henriette Hartung, Jonah Kammer, Norbert Sewald   +3 more
wiley   +1 more source

Identification of a <i>TOP3A</i> genetic variant as a novel biomarker for sensitivity to doxorubicin. [PDF]

Front Pharmacol
Takacova T, Schirmer MA.
europepmc   +1 more source

Mapping Mutations and Signaling Network Interactions to Guide Precision Therapy in Gallbladder Cancer

Cancer Reports, Volume 9, Issue 10, October 2026.
ABSTRACT Background Gallbladder cancer (GBC) is a biologically complex malignancy arising from the epithelial lining of the gallbladder, with adenocarcinoma constituting the major histological subtype. Early detection is challenging because of vague clinical manifestations and the organ's deep‐seated anatomical location, resulting in diagnosis at ...
Nisha Manav, Akanksha Kashyap, Lakshay Malhotra, Chethan Rajegowda, Chandra Prakash Prasad   +4 more
wiley   +1 more source

SLV‐404, an anti‐RYK antibody–drug conjugate, is effective in Richter transformation patient‐derived xenografts

HemaSphere, Volume 10, Issue 10, October 2026.
Abstract Richter transformation (RT), a highly aggressive lymphoma arising from a preexisting chronic lymphocytic leukemia, represents a major unmet clinical need. Recent data have shown that an antibody–drug conjugate (ADC) targeting the cell‐surface pseudokinase ROR1 is effective in RT patients.
Matilde Micillo, Beatrice Pirajno, Francesco Edoardo Vallone, Victor Navarro‐Tableros, Elisabetta Bolli, Valentina Griggio, Brian J. Lannutti, Katti A. Jessen, Tiziana Vaisitti, Silvia Deaglio   +9 more
wiley   +1 more source

Genomic and Phenotypic Characterization of Two Novel Enterobacter Phages With EDTA‐Enhanced Antibiofilm Activity

MicrobiologyOpen, Volume 15, Issue 5, October 2026.
Two novel lytic Enterobacter phages, HHH and RZH, displayed targeted antibiofilm activity against MDR Enterobacter cloacae complex biofilms when combined with EDTA. Activity was strongest within a narrow low‐millimolar EDTA window, reducing biofilm biomass and viable burden, while higher EDTA concentrations shifted the interaction towards antagonism ...
Kashif Haq, Zac Newland‐Smith, Martin Figgit, David Lee, Kwabena Duedu   +4 more
wiley   +1 more source

Barettin Suppresses Pancreatic Ductal Adenocarcinoma Proliferation via Topoisomerase IIα Inhibition. [PDF]

Mar Drugs
Seekins CA, Archuleta MR, Evans AE, Podgorski J, Carr JE, Kaleeswaran V, Nguyen KB, Flowers ME, Hulme C, Vanderah TW, Cárdenas P, Streicher JM, Lee NY, Cartmell C.   +13 more
europepmc   +1 more source