Results 181 to 190 of about 16,235 (248)

Infant Embryonal CNS Tumors: Molecular Insights and Treatment Considerations for Contemporary Pediatric Neuro‐Oncology

Pediatric Blood &Cancer, Volume 73, Issue 11, November 2026.
ABSTRACT Background Embryonal tumors comprise the majority of malignant central nervous system (CNS) neoplasms diagnosed in children under 3 years of age. Compared with their counterparts in older children, these tumors exhibit distinct molecular biology and a more aggressive clinical phenotype, while their management is complicated by the heightened ...
Sudarshawn Damodharan, Mariah Wright‐Nadkarni, Mohamed S. Abdelbaki, Girish Dhall   +3 more
wiley   +1 more source

Proteomic Analysis of Human Topoisomerases Reveals Their Distinct and Diverse Cellular Functions. [PDF]

Mol Cell Proteomics
Zhang H, Xiong Y, Chen Z, Chen J.
europepmc   +1 more source

Beneficial Role of Natural Polyphenols Against Epilepsy: Greasing the Wheels of Pharmacotherapy Research for Epilepsy

Food Frontiers, Volume 7, Issue 6, November 2026.
ABSTRACT Epilepsy is the most disabling neurological disease that affects all economic classes, age groups, regions, and races. Although many antiseizure drugs are approved for epilepsy treatment, they fail to work in about 30%–40% of patients. Thus, there is a great need to identify better pharmacological agents to treat epilepsy.
Janakiraman Pillai Udaiyappan, Rengasamy Balakrishnan, Manivasagam Muthukumaran Tamilarasan, Subasri Pandian   +3 more
wiley   +1 more source

Bacterial type II topoisomerases cleave DNA in a species-specific manner. [PDF]

Nucleic Acids Res
Morgan IL, Jian JY, Armenia JF, Osheroff N, Neuman KC.   +4 more
europepmc   +1 more source

Nerandomilast is Associated With Altered Alveolar Epithelial Cell State Dynamics While Attenuating Fibrotic Remodeling in Pulmonary Fibrosis

Genes to Cells, Volume 31, Issue 6, November 2026.
Nerandomilast treatment is associated with altered AT2 cell transcriptional programs and alveolar epithelial cell state dynamics, along with attenuated fibrotic remodeling and preservation of alveolar epithelial architecture. These findings suggest that nerandomilast may modulate alveolar epithelial responses during lung injury and repair.
Nanako Hamada, Yoshiaki Hayashi, Daisuke Motooka, Atsushi Kuwahara, Shizuo Akira, Kiyoharu Fukushima   +5 more
wiley   +1 more source

Chromosome segregation in a minimal bacterial cell driven by SMC protein complexes. [PDF]

Protein Sci
Maytin AK, Gilbert BR, Luthey-Schulten Z.   +2 more
europepmc   +1 more source

Diethylene Glycol‐Linked Ring‐Fused Bis‐Azoles: Target‐Oriented Synthesis, In Silico Screening, and Antitumor Activity

ChemMedChem, Volume 21, Issue 19, 14 October 2026.
A series of diethylene glycol‐linked cyclic derivatives with diversity in the heterocyclic motif have been synthesized and screened for antitumor activity. Two bis‐thiazolo[3,2‐a]pyrimidinone derivatives displayed moderate cytotoxicity, high selectivity against hepatocellular carcinoma cells, promising VEGFR2, and remarkable FGFR2 inhibitory activities
Sami A. Al‐Hussain, Abdulrahman S. Alharbi, Zeinab A. Muhammad, Alyaa S. Abdel Halim, Magdi E. A. Zaki, Mark C. Bagley, Refaie M. Kassab   +6 more
wiley   +1 more source

Topology Resetting During Transcription-Coupled Nucleotide Excision Repair. [PDF]

Int J Mol Sci
Lee TH, Jeon J, Jo SG, Kang TH.
europepmc   +1 more source

Multi‐regional Organoid Biobank Reveals FAK‐ACSL1‐Driven Doxorubicin‐Resistance and Predictive Biomarkers in Breast Cancer

Advanced Science, Volume 13, Issue 55, 5 October 2026.
This study established a high‐quality organoid biobank derived from 68 tumor sites across 50 Chinese patients, elucidated the drug sensitivity‐based molecular subtyping in breast cancer, and revealed a novel mechanism of drug resistance mediated by the FAK‐ACSL1 pathway.
Hao Xu, Zhijun Qin, Jiapeng Yang, Baoyuan Zhang, Manqing Cao, Peng Wang, Zaiqi Wang, Jinghui Cheng, Lei Wang, Hong Liu, Hui Yang   +10 more
wiley   +1 more source

Gyrase and Topoisomerase IV as Antibacterial Targets for Gepotidacin and Zoliflodacin: Teaching Old Enzymes New Tricks. [PDF]

Int J Mol Sci
Osheroff N.
europepmc   +1 more source