Results 51 to 60 of about 67,641 (348)
RNA topoisomerase is prevalent in all domains of life and associates with polyribosomes in animals [PDF]
, 2016 DNA Topoisomerases are essential to resolve topological problems during DNA metabolism in all species. However, the prevalence and function of RNA topoisomerases remain uncertain.
Ahmad, Muzammil +20 more
core +3 more sources
Clinical Significance of Expression of Topoisomerase 2а in Breast Cancer
Антибиотики и Химиотерапия, 2020 Topoisomerases are enzymes that control the topology of DNA. Topoisomerases are divided into types 1 and 2, depending on the mechanism of action. The article discusses the structure and mechanisms of the action of topoisomerases, the possibility of an ...
A. A. Samuseva +3 more
doaj
Topological Process of Splitting DNA-Links
Biomath, 2022 A DNA replicon is modeled by a special type of 2-component link, called a DNA-link, in which two circles form a double helix around a trivial center core curve.
Abdul Adheem Mohamad, Tsukasa Yashiro
doaj +1 more source
Topoisomerase IV can functionally replace all type 1A topoisomerases in Bacillus subtilis
Nucleic Acids Research, 2019 DNA topoisomerases play essential roles in chromosome organization and replication. Most bacteria possess multiple topoisomerases which have specialized functions in the control of DNA supercoiling or in DNA catenation/decatenation during recombination ...
Daniel R. Reuß +9 more
semanticscholar +1 more source
Type IA Topoisomerases as Targets for Infectious Disease Treatments
Microorganisms, 2021 Infectious diseases are one of the main causes of death all over the world, with antimicrobial resistance presenting a great challenge. New antibiotics need to be developed to provide therapeutic treatment options, requiring novel drug targets to be ...
Ahmed Seddek +2 more
doaj +1 more source
Structural insights into the gating of DNA passage by the topoisomerase II DNA-gate. [PDF]
, 2018 Type IIA topoisomerases (Top2s) manipulate the handedness of DNA crossovers by introducing a transient and protein-linked double-strand break in one DNA duplex, termed the DNA-gate, whose opening allows another DNA segment to be transported through to ...
Chan, Nei-Li +7 more
core +2 more sources
Biomolecules, 2019 : Indole-3-acetic acid (IAA) is a major plant hormone that affects many cellular processes in plants, bacteria, yeast, and human cells through still unknown mechanisms.
Roberto Defez +7 more
doaj +1 more source
Roles of Topoisomerases in Heterochromatin, Aging, and Diseases
Genes, 2019 Heterochromatin is a transcriptionally repressive chromatin architecture that has a low abundance of genes but an enrichment of transposons. Defects in heterochromatin can cause the de-repression of genes and transposons, leading to deleterious ...
Seung kyu Lee, Weidong Wang
semanticscholar +1 more source
Transcription as a Threat to Genome Integrity [PDF]
, 2016 Genomes undergo different types of sporadic alterations, including DNA damage, point mutations, and genome rearrangements, that constitute the basis for evolution.
Aguilera López, Andrés +1 more
core +1 more source
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source