Results 101 to 110 of about 629,691 (304)

A Multi‐Objective Molecular Generation Method Based on Pareto Algorithm and Monte Carlo Tree Search

open access: yesAdvanced Science, EarlyView.
Pareto Monte Carlo Tree Search Molecular Generation (PMMG), a molecular generation approach leveraging Monte Carlo Tree Search (MCTS) and Pareto algorithm, efficiently explores the Pareto front in high‐dimensional objective spaces for multi‐objective drug design.
Yifei Liu   +12 more
wiley   +1 more source

Topological amplitude computations using the pure spinor formalism

open access: yesJournal of High Energy Physics, 2019
After constructing a simplified four-dimensional version of the b ghost, topological multiloop amplitudes in type II superstring theory compactified on a six-dimensional orbifold are computed using the non-minimal pure spinor formalism. These pure spinor
Nathan Berkovits, Luis Alberto Ypanaqué
doaj   +1 more source

String topology for spheres

open access: yesCommentarii Mathematici Helvetici, 2009
Let M be a compact oriented d -dimensional smooth manifold. Chas and Sullivan have defined a structure of Batalin–Vilkovisky algebra on ℍ_∗(LM) .
openaire   +5 more sources

NKX2‐5/LHX1 and UHRF1 Establishing a Positive Feedback Regulatory Circuitry Drives Esophageal Squamous Cell Carcinoma through Epigenetic Dysregulation

open access: yesAdvanced Science, EarlyView.
The study identifies a positive feed‐forward loop that intertwines DNA methylation regulator UHRF1 with Homeobox genes‐NKX2‐5/LHX1 via UMRs as a critical driver of ESCC. Pharmacological inhibition of UHRF1 and DNMT activity inhibits ESCC growth, which may represent a promising therapeutic approach to treat ESCC patients dependent on NKX2‐5/LHX1/UHRF1 ...
Xukun Li   +13 more
wiley   +1 more source

Random Generation Topology Coding Technique in Asymmetric Topology Encryption

open access: yesMathematics
The security of traditional public key cryptography algorithms depends on the difficulty of the underlying mathematical problems. Asymmetric topological encryption is a graph-dependent encryption algorithm produced to resist attacks by quantum computers ...
Jing Su, Bing Yao
doaj   +1 more source

Defects in the 3-dimensional toric code model form a braided fusion 2-category

open access: yesJournal of High Energy Physics, 2020
It was well known that there are e-particles and m-strings in the 3-dimensional (spatial dimension) toric code model, which realizes the 3-dimensional ℤ2 topological order.
Liang Kong, Yin Tian, Zhi-Hao Zhang
doaj   +1 more source

Quantum periods and TBA-like equations for a class of Calabi-Yau geometries

open access: yesJournal of High Energy Physics, 2021
We continue the study of a novel relation between quantum periods and TBA(Thermodynamic Bethe Ansatz)-like difference equations, generalize previous works to a large class of Calabi-Yau geometries described by three-term quantum operators.
Bao-ning Du, Min-xin Huang
doaj   +1 more source

Generalized string topology operations [PDF]

open access: yesProceedings of the London Mathematical Society, 2007
We show that the Chas-Sullivan loop product, a combination of the Pontrjagin product on the fiber and intersection product on the base, makes sense on the total space homology of any fiberwise monoid E over a closed oriented manifold M. More generally the Thom spectrum E^{-TM} is a ring spectrum.
Gruher, K, SALVATORE, PAOLO
openaire   +5 more sources

Monopoles on strings

open access: yes, 2015
In cosmological scenarios based on grand unification, string theory or braneworlds, many kinds of topological or non-topological defects, including monopoles and cosmic strings, are predicted to be formed in the early universe.
Kibble, T. W. B., Vachaspati, Tanmay
core   +1 more source

Jacobi sigma models

open access: yesJournal of High Energy Physics, 2021
We introduce a two-dimensional sigma model associated with a Jacobi manifold. The model is a generalisation of a Poisson sigma model providing a topological open string theory.
Francesco Bascone   +2 more
doaj   +1 more source

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