Results 101 to 110 of about 935 (235)

Accelerating Primary Screening of USP8 Inhibitors from Drug Repurposing Databases with Tree‐Based Machine Learning

Advanced Intelligent Discovery, EarlyView.
This study introduces a tree‐based machine learning approach to accelerate USP8 inhibitor discovery. The best‐performing model identified 100 high‐confidence repurposable compounds, half already approved or in clinical trials, and uncovered novel scaffolds not previously studied. These findings offer a solid foundation for rapid experimental follow‐up,
Yik Kwong Ng, Sharon Ai Er Lam, Wei Chun Lim, Hannah Hui Min Toh, Shi Jun Ang   +4 more
wiley   +1 more source

Topological structures, dark matter and gravitational waves in E6

Journal of High Energy Physics
We discuss the appearance of topological structures from the spontaneous breaking of E 6 to the Standard Model via its maximal subgroup SO(10) × U(1) ψ . They include dumbbells, metastable strings, as well as domain walls bounded by necklaces. We provide
Rinku Maji, Qaisar Shafi, Amit Tiwari
doaj   +1 more source

A Unifying Approach to Self‐Organizing Systems Interacting via Conservation Laws

Advanced Intelligent Discovery, EarlyView.
The article develops a unified way to model and analyze self‐organizing systems whose interactions are constrained by conservation laws. It represents physical/biological/engineered networks as graphs and builds projection operators (from incidence/cycle structure) that enforce those constraints and decompose network variables into constrained versus ...
F. Barrows, G. Zhang, S. Anand, Z. Chen, J. Lin, A. Desai, S. Martiniani, F. Caravelli   +7 more
wiley   +1 more source

Harnessing Machine Learning to Understand and Design Disordered Solids

Advanced Intelligent Discovery, EarlyView.
This review maps the dynamic evolution of machine learning in disordered solids, from structural representations to generative modeling. It explores how deep learning and model explainability transform property prediction into profound physical insight.
Muchen Wang, Yue Fan
wiley   +1 more source

Artificial Intelligence‐Driven Network Pharmacology: A Methodological Paradigm Shift Bridging Traditional Wisdom and Modern Science

Advanced Intelligent Discovery, EarlyView.
Artificial intelligence is redefining network pharmacology (NP). By integrating knowledge graph engineering, geometric deep learning, multiomics anchoring, and generative reasoning, AI‐driven NP (AI‐NP) transforms static target mapping into dynamic, predictive modeling.
Cong Wang, Sile Hu, Rigahai Ji, Riguna A, Siqige Hao, Ma Zhuo, Yi‐Hung Chen, Bisihalatu Hu, Ulana Bai, Xigui Hada   +9 more
wiley   +1 more source

Topological aspects of string theories

Nuclear Physics B, 1987
In previous work, a new action principle for strings and superstrings in arbitrary dimensions was developed. It led to a classification of strings similar to the classification of point particles as massive, massless and tachyonic. Topological aspects of four-dimensional strings were also investigated.
A. P. BALACHANDRAN, LIZZI, FEDELE, R. D. SORKIN, G. SPARANO   +3 more
openaire   +3 more sources

Towards Advanced Intelligent and Perceptive Soft Grippers

Advanced Intelligent Systems, EarlyView.
Implementing soft yet strong and intelligent soft grippers request innovative and creative solutions in designing soft bodies and seamlessly integrating actuated systems with hierarchical sensing. This review systematically analyses soft grippers with a deep understanding of core components, from fundamental design principles to actuation and sensing ...
Haneul Kim, Hayeon Shin, Seik Park, Changbeom Shim, Seonggun Joe   +4 more
wiley   +1 more source

Electromagnetic vacuum fluctuations around a cosmic string in de Sitter spacetime

European Physical Journal C: Particles and Fields, 2017
The electromagnetic field correlators are evaluated around a cosmic string in background of $$(D+1)$$ ( D + 1 ) -dimensional dS spacetime assuming that the field is prepared in the Bunch–Davies vacuum state.
A. A. Saharian, V. F. Manukyan, N. A. Saharyan   +2 more
doaj   +1 more source

Discovery of a Bloch point quadrupole constituting hybrid topological strings [PDF]

, 2023
Fehmi Sami Yasin, Jan Masell, Yoshio Takahashi, Tetsuya Akashi, Norio Baba, Kosuke Karube, Daisuke Shindo, T. Arima, Y. Taguchi, Yoshinori Tokura, Toshiaki Tanigaki, Xiuzhen Yu   +11 more
openalex   +1 more source

Guiding and Manipulating Light Fields in Microstructured Liquid Crystals

Advanced Physics Research, EarlyView.
This review summarizes recent advances in guided‐wave optics enabled by microstructured liquid crystal (LC) devices, covering their fundamental material properties, key degree of freedom for dynamic light field manipulations. The advances of linear guided‐wave optics, nonlinear‐optics with spatial optical solitons, and microlasers in LC‐based devices ...
Shan‐shan Chang, Yong‐shuai Li, Jin‐hui Chen   +2 more
wiley   +1 more source