Results 41 to 50 of about 2,265,648 (271)

POU2AF1 (POU domain, class 2, associating factor 1) [PDF]

, 1998
Review on POU2AF1 (POU domain, class 2, associating factor 1), with data on DNA, on the protein encoded, and where the gene is ...
Galiègue-Zouitina, Sylvie
core   +1 more source

Sub-kb Hi-C in D. melanogaster reveals conserved characteristics of TADs between insect and mammalian cells

Nature Communications, 2018
Topologically associating domain (TAD) boundaries in flies seem to be different from those in mammals. Here, the authors use Hi-C with sub-kb resolution to identify about 4000 TADs in flies, most demarcated by the insulator complexes BEAF-32/CP190 or ...
Qi Wang, Qiu Sun, Daniel M. Czajkowsky, Zhifeng Shao   +3 more
doaj   +1 more source

The generation of PD-L1 and PD-L2 in cancer cells: From nuclear chromatin reorganization to extracellular presentation

Acta Pharmaceutica Sinica B, 2022
The immune checkpoint blockade (ICB) targeting on PD-1/PD-L1 has shown remarkable promise in treating cancers. However, the low response rate and frequently observed severe side effects limit its broad benefits.
Zhiwei Fan, Changyue Wu, Miaomiao Chen, Yongying Jiang, Yuanyuan Wu, Renfang Mao, Yihui Fan   +6 more
doaj   +1 more source

Enhancer Chromatin and 3D Genome Architecture Changes from Naive to Primed Human Embryonic Stem Cell States

Stem Cell Reports, 2019
Summary: During mammalian embryogenesis, changes in morphology and gene expression are concurrent with epigenomic reprogramming. Using human embryonic stem cells representing the preimplantation blastocyst (naive) and postimplantation epiblast (primed ...
Stephanie L. Battle, Naresh Doni Jayavelu, Robert N. Azad, Jennifer Hesson, Faria N. Ahmed, Eliah G. Overbey, Joseph A. Zoller, Julie Mathieu, Hannele Ruohola-Baker, Carol B. Ware, R. David Hawkins   +10 more
doaj   +1 more source

TAD-like single-cell domain structures exist on both active and inactive X chromosomes and persist under epigenetic perturbations

Genome Biology, 2021
Background Topologically associating domains (TADs) are important building blocks of three-dimensional genome architectures. The formation of TADs has been shown to depend on cohesin in a loop-extrusion mechanism.
Yubao Cheng, Miao Liu, Mengwei Hu, Siyuan Wang   +3 more
doaj   +1 more source

Mysteries of gene regulation: Promoters are not the sole triggers of gene expression

Computational and Structural Biotechnology Journal, 2022
Cis-regulatory elements of promoters are essential for gene regulation by transcription factors (TFs). However, the regulatory roles of nonpromoter regions, TFs, and epigenetic marks remain poorly understood in plants. In this study, we characterized the
Chi-Nga Chow, Kuan-Chieh Tseng, Ping-Fu Hou, Nai-Yun Wu, Tzong-Yi Lee, Wen-Chi Chang   +5 more
doaj   +1 more source

Topologically Associated Domains Delineate Susceptibility to Somatic Hypermutation

Cell Reports, 2019
Somatic hypermutation (SHM) introduces point mutations into immunoglobulin (<i>Ig</i>) genes of activated B cells to support the process of antibody affinity maturation but also causes "off-target" mutations in other parts of the genome. We have used sensitive lentiviral SHM reporter vectors and a mutationally active human B cell line to ...
Filip Senigl, Yaakov Maman, Ravi K. Dinesh, Jukka Alinikula, Rashu B. Seth, Lubomira Pecnova, Arina D. Omer, Suhas S. P. Rao, David Weisz, Jean-Marie Buerstedde, Rafael Casellas, Erez Lieberman Aiden, Jiri Hejnar, David Schatz   +13 more
openaire   +5 more sources

TADKB: Family classification and a knowledge base of topologically associating domains [PDF]

BMC Genomics, 2019
Abstract Background Topologically associating domains (TADs) are considered the structural and functional units of the genome. However, there is a lack of an integrated resource for TADs in the literature where researchers can obtain family classifications and detailed information about TADs.
Liu, Tong, Porter, Jacob, Zhao, Chenguang, Zhu, Hao, Wang, Nan, Sun, Zheng, Mo, Yin-Yuan, Wang, Zheng   +7 more
openaire   +3 more sources

Tight DNA-protein complexes isolated from barley seedlings are rich in potential guanine quadruplex sequences [PDF]

PeerJ, 2020
Background The concept of chromatin domains attached to the nuclear matrix is being revisited, with nucleus described as a set of topologically associating domains. The significance of the tightly bound to DNA proteins (TBP), a protein group that remains
Tatjana Sjakste, Elina Leonova, Rudolfs Petrovs, Ilva Trapina, Marion S. Röder, Nikolajs Sjakste   +5 more
doaj   +2 more sources

Enhancer-instructed epigenetic landscape and chromatin compartmentalization dictate a primary antibody repertoire protective against specific bacterial pathogens [PDF]

, 2023
Antigen receptor loci are organized into variable (V), diversity (D) and joining (J) gene segments that rearrange to generate antigen receptor repertoires.
Barajas-Mora, E Mauricio, Bjanes, Elisabet, Lee, Lindsay, Lu, Hanbin, Murre, Cornelis, Hu, Ming, Nizet, Victor, Feeney, Ann J, Valderrama, J Andrés, Andrés Valderrama, J., Hanbin Lu, E. Mauricio Barajas-Mora, Lindsay Lee, Mauricio Barajas-Mora, E., Victor Nizet, Ming Hu, Elisabet Bjanes, Feeney, Ann J., J. Andrés Valderrama, Ann J. Feeney, Cornelis Murre   +20 more
core   +1 more source