Results 51 to 60 of about 329,929 (341)

STRUCTURAL TOPOLOGY OPTIMIZATION FOR FLOOR BEAM OF RACK EMU BODY CONSIDERING MODAL FACTORS

open access: yesJixie qiangdu, 2022
The lightweight of rack EMU(Electric Multiple Units)body is one of the key factors to realize the strong climbing ability and comfort of rack EMU. Aiming at the lightweight design of rack EMU body floor beam, a structural design method combining 2 D with
CHEN RuiWen   +4 more
doaj  

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

open access: yesFEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani   +4 more
wiley   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

open access: yesFEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang   +9 more
wiley   +1 more source

Research on Configuration Synthesis of Actuator for Underwater Vehicle Receiving and Placing System

open access: yesJixie chuandong, 2023
Aiming at the problems of single structure form and limited transporting range of existing underwater vehicle receiving and placing system, comprehensive research on actuator configuration of the receiving and placing system are carried out with the help
Jiang Mingyang   +4 more
doaj  

Geometric approach to Hamiltonian dynamics and statistical mechanics

open access: yes, 1999
This paper is a review of results which have been recently obtained by applying mathematical concepts drawn, in particular, from differential geometry and topology, to the physics of Hamiltonian dynamical systems with many degrees of freedom of interest ...
Casetti, Lapo   +2 more
core   +1 more source

The Gribov Ambiguity for Maximal Abelian and Center Gauges in SU(2) Lattice Gauge Theory [PDF]

open access: yes, 2000
We present results for the fundamental string tension in SU(2) lattice gauge theory after projection to maximal abelian and direct maximal center gauges. We generate 20 Gribov copies/configuration.
't Hooft   +10 more
core   +3 more sources

Topological susceptibility on dynamical staggered fermion configurations [PDF]

open access: yesPhysical Review D, 2001
The topological susceptibility is one of the few physical quantities that directly measure the properties of the QCD vacuum. Chiral perturbation theory predicts that in the small quark mass limit the topological susceptibility depends quadratically on the pion mass, approaching zero in the chiral limit.
openaire   +2 more sources

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

open access: yesFEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman   +2 more
wiley   +1 more source

Phase transitions as topology changes in configuration space: an exact result

open access: yes, 2001
The phase transition in the mean-field XY model is shown analytically to be related to a topological change in its configuration space. Such a topology change is completely described by means of Morse theory allowing a computation of the Euler ...
A. Cavagna   +14 more
core   +1 more source

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