Results 61 to 70 of about 1,164,927 (295)
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
An automated topological analysis of Multiple Routing Configurations
2015 36th IEEE Sarnoff Symposium, 2015 Topological changes in IP networks may significantly influence the performance of networking algorithms, which therefore should be carefully evaluated using a large topology pool with diverse characteristics. In this paper, we present an automated topology generation and analysis tool to perform an elaborate topological dependency analysis of a Multi ...
Selcuk Cevher +2 more
openaire +2 more sources
D-sphalerons and the topology of string configuration space [PDF]
Journal of High Energy Physics, 2000 We show that unstable D-branes play the role of ``D-sphalerons'' in string theory. Their existence implies that the configuration space of Type II string theory has a complicated homotopy structure, similar to that of an infinite Grassmannian. In particular, the configuration space of Type IIA (IIB) string theory on $\R^{10}$ has non-trivial homotopy ...
Harvey, Jeffrey A. +2 more
openaire +3 more sources
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
Cellular structures in Topology [PDF]
, 1990 This book describes the construction and the properties of CW-complexes. These spaces are important because firstly they are the correct framework for homotopy theory, and secondly most spaces that arise in pure mathematics are of this type.
Renzo Piccinini +4 more
core +1 more source
Topology Optimization of a Parallel-Leg Jacket Substructure for a 10 MW Offshore Wind Turbine
Journal of Marine Science and EngineeringThis study proposes a parallel-leg jacket concept for a 10 MW offshore wind turbine and employs density-based topology optimization as a concept-stage load-path guidance tool to develop a lightweight tubular jacket configuration.
Nouman Saeed +4 more
doaj +1 more source
Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding
FEBS Letters, EarlyView.In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança +2 more
wiley +1 more source
Configuration spaces of thick particles on graphs [PDF]
, 2011 In this thesis, we study the topology of configuration spaces of particles of variable radius r>0 moving on a metric graph. Our main tool is a piecewise linear (PL) Morse-Bott theory for affine polytope complexes, which extends the Morse theory for such ...
DEELEY, KENNETH
core
Topology optimization analysis of VLCC transverse web based on UNet deep learning
Zhongguo Jianchuan YanjiuObjectiveThis paper proposes a hull transverse web topology optimization method based on UNet for application in the optimization design of complex ship structures.
Zhenrong LI, Lijuan XIA, Shuo FENG
doaj +1 more source
Research on Configuration Synthesis of Actuator for Underwater Vehicle Receiving and Placing System
Jixie chuandong, 2023 Aiming at the problems of single structure form and limited transporting range of existing underwater vehicle receiving and placing system, comprehensive research on actuator configuration of the receiving and placing system are carried out with the help
Jiang Mingyang +4 more
doaj