Results 51 to 60 of about 1,164,927 (295)
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
ACM SIGCOMM Computer Communication Review, 2002 Advances in microsensor and radio technology enable small but smart sensors to be deployed for a wide range of environmental monitoring applications. The low-per node cost allows these wireless networks of sensors and actuators to be densely distributed. The nodes in these dense networks coordinate to perform the distributed sensing and actuation tasks.
Cerpa, Alberto E, Estrin, D
openaire +4 more sources
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
Computational topology for configuration spaces of hard disks [PDF]
Physical Review E, 2012 version 3: 16 pages, 11 figures; made minor changes requested by journal --- changed some color figures to black and white, and reordered bibliography to appear in order of citation rather than alphabetical ...
Gunnar E. Carlsson +3 more
openaire +4 more sources
Ferroelectric topologically configurable multilevel logic unit
Neuromorphic Computing and Engineering, 2023 Abstract Multilevel devices demonstrating switchable polarization enable us to efficiently realize neuromorphic functionalities including synaptic plasticity and neuronal activity. Here we propose using the ferroelectric logic unit comprising multiple nanodots disposed between two electrodes and coated by the dielectric material.
Anna G. Razumnaya +3 more
openaire +3 more sources
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
STRUCTURAL TOPOLOGY OPTIMIZATION FOR FLOOR BEAM OF RACK EMU BODY CONSIDERING MODAL FACTORS
Jixie qiangdu, 2022 The lightweight of rack EMU（Electric Multiple Units）body is one of the key factors to realize the strong climbing ability and comfort of rack EMU. Aiming at the lightweight design of rack EMU body floor beam, a structural design method combining 2 D with
CHEN RuiWen +4 more
doaj
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
Energy Reports, 2021 A novel design of a shell-and-tube thermal energy storage unit with phase change material was proposed in the study. The layouts of highly conductive fins and phase change material (PCM) in the energy storage unit were optimized through the topology ...
Tingwei Zhang +2 more
doaj +1 more source
Arbitrarily Configurable Nonlinear Topological Modes
Physical Review LettersTopological modes (TMs) are typically localized at boundaries, interfaces and dislocations, and exponentially decay into the bulk of a large enough lattice. Recently, the non-Hermitian skin effect has been leveraged to delocalize the wavefunctions of TMs from the boundary and thus to increase the capacity of TMs dramatically.
Kai Bai +5 more
openaire +3 more sources