Results 91 to 100 of about 21,546 (268)

Palaeoglaciations in the Polar and Subpolar Ural Mountains

Boreas, EarlyView.
The Ural Mountains form a major physiographic boundary between the East European Plain and West Siberia, both repeatedly glaciated during the Pleistocene by the Barents–Kara ice sheet. Although the present‐day topography reflects significant glacial modification, the extent, chronology and interaction of mountain glaciers with the Barents–Kara ice ...
Bartosz Kurjanski, Matteo Spagnolo, Irina Bushueva, Iestyn Barr, Brice R. Rea, Olga Solomina, Stanislav Kutuzov   +6 more
wiley   +1 more source

New biosensors and transgenic mice for multiplex cGMP imaging

British Journal of Pharmacology, EarlyView.
Background and Purpose Cyclic guanosine monophosphate (cGMP) is a versatile second messenger that is important for human (patho‐)physiology and pharmacotherapy. Live‐cell imaging of cGMP with biosensors allows to elucidate its spatiotemporal dynamics in real time under close‐to‐native conditions. However, to monitor two separate cGMP pools or cGMP/cAMP
Markus Wolters, Martin Thunemann, Barbara Birk, Susanne Feil, Viacheslav O. Nikolaev, Moritz Lehners, Robert Feil   +6 more
wiley   +1 more source

The fundamental progroupoid of a general topos [PDF]

, 2008
It is well known that the category of covering projections (that is, locally constant objects) of a locally connected topos is equivalent to the classifying topos of a strict progroupoid (or, equivalently, a localic prodiscrete groupoid), the fundamental
Dubuc, Eduardo Julio, Dubuc, Eduardo J.
core   +1 more source

Wee1 kinase differentially regulates maize CDKA2;1a and CDKB1;1

The FEBS Journal, EarlyView.
In eukaryotes, Wee1 kinase inhibits the kinase activity of CDK/Cyc complexes through phosphorylation of a conserved residue in the CDK moiety. Wee1 is also present in plants, but has been scarcely studied. We have studied maize Wee1 regulation of CDKA/CycD2;2a or CDKB/CycD2;2a complexes.
Mingyar N. López‐Hernández, Estefany D. Guerrero‐Molina, Ulises Martínez‐Ortega, Aurora Lara‐Núñez, Jorge M. Vázquez‐Ramos   +4 more
wiley   +1 more source

SEMILATTICES AND K-FINITE OBJECTS

Revista de Matemática: Teoría y Aplicaciones, 2017
We prove that for X Є  ǀ E ǀ, E elementary topos, the following properties are equivalent: (a) X is K-finite, (b) for every upper semilattice B, the diagonal B → BX has a left adjoint.
OSVALDO ACUÑA ORTEGA
doaj   +1 more source

Functional and transcriptomic analyses in Neurospora crassa reveal a crucial role for the N‐glycoprotein deglycosylation process in fungal homeostasis

The FEBS Journal, EarlyView.
In Neurospora crassa, a cytosolic GH18 endo‐β‐n‐acetylglucosaminidase (ENGase) functions as an active deglycosylating enzyme. Deletion of this severely alters tolerance to multiple stress conditions and causes extensive transcriptomic reprogramming, including upregulation of a GH20 exo‐β‐n‐acetylhexosaminidase under ER stress, indicating that N. crassa
Anastasios Samaras, Tanim Jabid Hossain, Magnus Karlsson, Georgios Tzelepis   +3 more
wiley   +1 more source

Newly identified human aminoacyl‐tRNA synthetase complex interacting multifunctional protein 2 (AIMP2) loss‐of‐function mutations cause neurodevelopmental defects linked to cell death in a zebrafish model

The FEBS Journal, EarlyView.
Human AIMP2 mutations lead to severe neurodevelopmental defects and brain atrophy. Using patient‐derived fibroblasts from two individuals, we show decreased AIMP2 protein levels and overall protein synthesis. In a zebrafish loss‐of‐function model, the lack of AIMP2 leads to an increase in cell death and results in smaller brains.
Patrick Mullen, Shenela Lakhani, Joshua Appelbaum, DéJenaé See, Pryce Patterson, Collin M. MacLeod, Alexandra George, Reza Maroofian, Margaret E. Ross, Christopher Francklyn, Alicia M. Ebert   +10 more
wiley   +1 more source

Generating Families in a Topos

Theory and Applications of Categories, 2006
A generating family in a category \(\mathcal C\) is a collection of objects \(\{A_i|i\in I\}\) such that if for any subobject \(Y\overset {m}\rightarrowtail X\), every \(f: A_i @>f>> X\) factors through \(m\), then \(m\) is an isomorphism -- i.e., the functors \({\mathcal C}(A_{i, -})\) are collectively conservative.
openaire   +2 more sources

Toward a minimal amino acid alphabet for protein design

The FEBS Journal, EarlyView.
Proteins are built from 20 canonical amino acids; however, it is interesting to investigate whether they can also be formed from reduced amino acid alphabets. Using protein design, we designed proteins based on all alphabets comprising 2 to 10 ‘early’ amino acids (those likely to have been present before the origin of life).
Karel Půbal, Kseniia Kushnir, Vojtěch Spiwok, Karolína Loužecká, Vladimír Setnička, Petra Lipovová   +5 more
wiley   +1 more source

Evaluating Suitability for Surface Managed Aquifer Recharge to Enhance Dry‐Season Stream Flows

Groundwater, EarlyView.
Identifying suitable sites for surface MAR projects to enhance dry‐season stream flow requires evaluating the geology of the aquifer, depth to groundwater, soil permeability, topographic slope, the distance between the infiltration basin and receiving surface water, and other factors.
Andrew L. Bobst, Ann E.H. Hanson
wiley   +1 more source