Results 101 to 110 of about 22,889 (244)
Preclinical pharmacology and clinical uses of topotecan
, 1999 Topotecan, a soluble semisynthetic derivative of camptothecin, is a specific inhibitor of topoisomerase I and is endowed of potent antiproliferative effect in vitro and in vivo on tumoral cell lines as well as on endothelial cells. Moreover, topotecan is
DEL TACCA M +2 more
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A review of topotecan in combination chemotherapy for advanced cervical cancer
, 2008 Minoo Robati, David Holtz, Charles J DuntonDepartment of Obstetrics and Gynecology, Main Line Gynecologic Oncology, Lankenau Hospital, Wynnewood, PA, USAAbstract: Treatment of advanced, recurrent or persistent cervical cancer includes radiotherapy and ...
David Holtz +2 more
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BMC Cancer, 2007 Background A platinum doublet is the current standard treatment for good performance status patients with advanced non-small cell lung cancer (NSCLC) and extensive stage small cell lung cancer (SCLC) with good performance status.
Kraft Andrew S +7 more
doaj +1 more source
Topotecan uptake and efflux in topotecan resistant cancer cells
, 2000 喜樹鹼能抑制第一型拓蹼異構酵素，在實驗室中可抑制癌細胞生長。Topotecan及CPT-11 是兩個喜樹鹼的衍生物，最近已 開發成功。Topotecan 可治療卵巢癌而CPT-11 可治療大腸癌。目前二者都使用在各種癌症的臨床試驗，以尋求更廣泛的適 應症。以喜樹鹼置於癌細胞生長培養液中，往往產生對所有喜樹鹼衍生物的抗藥性。進一步分析可發現，抗藥性癌細胞中，第一型拓蹼異構酵素可能會下降或是產生突變，以致對喜樹鹼抑制劑的敏感度下降。我們先前發現，以第二型拓蹼異構酵素抑制劑mitoxantrone ...
楊志新
core
Response to carboplatin +/− topotecan-containing ophthalmic artery chemosurgery (OAC).
, 2013 Representative case. Left: Reese-Ellsworth Group VB (IC D) left eye prior to treatment Right: Same eye following three OAC cycles consisting of carboplatin and topotecan. Note dramatic response of tumors following carboplatin/topotecan therapy.
Brian P. Marr (307426) +6 more
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International Journal of Gynecologic Cancer, 2017 Objective Despite advances in cervical cancer prevention and diagnosis, outcomes for patients given a diagnosis of advanced and recurrent disease are poor.
V. Rosen +6 more
semanticscholar +1 more source
, 2009 Background : Novobiocin was shown to sensitize cancer cells to etoposide and alkylating agents. Human breast carcinoma cells exposed to topotecan ( MCF7/TPT-300 cells) developed resistance to both mitoxantrone and topotecan.
YANG, CHIH-HSIN;CHEN, YAO-CHANG;KUO, MIN-LIANG +1 more
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Recurrent encephaloclastic cyst induced by intraventricular topotecan
, 2015 To report two rare cases of encephaloclastic cyst induced by intraventricular topotecan. To share our experience in diagnosing and treating this rare disease. Ommaya reservoirs provide fast access and reliable drug delivery to cerebral spinal fluid. They
Kamiya-Matsuoka, Carlos +5 more
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Ocular and systemic toxicity of intravitreal topotecan in rabbits for potential treatment of retinoblastoma [PDF]
, 2013 Treatment of intraocular retinoblastoma with vitreous seeding is a challenge. Different routes of chemotherapy administration have been explored in order to attaining pharmacological concentrations into the posterior chamber.
Buitagro, Emiliano +8 more
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International Journal of Molecular Sciences, 2018 The major cause of ovarian cancer treatment failure in cancer patients is inherent or acquired during treatment drug resistance of cancer. Matrix Gla protein (MGP) is a secreted, non-collagenous extracellular matrix protein involved in inhibition of ...
K. Sterzyńska +10 more
semanticscholar +1 more source