Inter- and intrapatient variability in oral topotecan pharmacokinetics: implications for body-surface area dosage regimens [PDF]
, 2000 Anticancer drugs still are dosed based on the body-surface area (BSA) of the individual patient, although the BSA is not the main predictor of the clearance for the majority of drugs.
Gelderblom, A.J. (Hans) +4 more
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Dose banding as an alternative to body surface area-based dosing of chemotherapeutic agents [PDF]
, 2012 Background: Dose banding is a recently suggested dosing method that uses predefined ranges (bands) of body surface area (BSA) to calculate each patients dose by using a single BSA-value per band.
Baker, S.D. (Sharyn) +5 more
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FL118, a novel camptothecin derivative, is insensitive to ABCG2 expression and shows improved efficacy in comparison with irinotecan in colon and lung cancer models with ABCG2-induced resistance [PDF]
, 2015 International audienceAbstractBackgroundIrinotecan is a camptothecin analogue currently used in clinical practice to treat advanced colorectal cancer. However, acquired resistance mediated by the drug efflux pump ABCG2 is a recognized problem.
Celine Gongora +8 more
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DiagnosticsBackground: Small-cell lung cancer (SCLC) is a highly aggressive tumor, and overall survival (OS) remains poor despite intensive efforts to develop new treatment strategies.
Laura Lambrecht +5 more
doaj +1 more source
OncoImmunology, 2018 Despite recent advances in high-risk neuroblastoma therapy, the prognosis for patients remains poor. In addition, many patients suffer from complications related to available therapies that are highly detrimental to their quality of life.
S. Faraj +9 more
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Quantification and expert evaluation of evidence for chemopredictive biomarkers to personalize cancer treatment. [PDF]
, 2017 Predictive biomarkers have the potential to facilitate cancer precision medicine by guiding the optimal choice of therapies for patients. However, clinicians are faced with an enormous volume of often-contradictory evidence regarding the therapeutic ...
Beckman, Robert A. +8 more
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Patent Disclosure and R&D Competition in Pharmaceuticals. [PDF]
The prominent role played by patents within the pharmaceutical domain is unquestionable. In this paper we take an unusual perspective and focus on a relatively neglected implication of patents: the effect of patent-induced information disclosure (of both
Fabio Pammolli +3 more
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Mechanisms of nuclear content loading to exosomes. [PDF]
, 2019 Exosome cargoes are highly varied and include proteins, small RNAs, and genomic DNA (gDNA). The presence of gDNA suggests that different intracellular compartments contribute to exosome loading, resulting in distinct exosome subpopulations.
Burks, Jared K +13 more
core
Immediate Versus Delayed Topotecan after First-line Therapy in Small Cell Lung Cancer
Chinese Journal of Lung Cancer, 2010 Background and objective How to prolong progression free survival (PFS) and overall survival (OS) of patients with small cell lung cancer (SCLC) has been one of the hottest issues. We retrospectively reviewed our data to compare the survival of immediate
Cong XUE +7 more
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