Results 121 to 130 of about 22,889 (244)
Topotecan in platinum-resistant epithelial ovarian cancer
, 2005 Background: Topotecan has been emerged as a new promising anticancer drug for patients with ovarian cancer. Methods: In this study, patients who were treated with topotecan were reviewed retrospectively. A total of 26 patients was included the study. All
Dikmen Y. +8 more
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Phase I and pharmacologic study of topotecan in patients with impaired renal function.
, 1996 PURPOSE To determine the toxicities, pharmacokinetics, and recommended doses of the topoisomerase I inhibitor, topotecan, in patients with varying degrees of renal excretory dysfunction.
A A Forastiere +8 more
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, 2000 PURPOSE: In in vitro studies, synergism and sequence-dependent effects were reported for the combination of topotecan and cisplatin. Recently, an oral formulation of topotecan became available.
Walter J. Loos +12 more
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, 2018 Mohammad Hassan Hodroj, Achraf Jardaly, Sarah Abi Raad, Annalise Zouein, Sandra Rizk Department of Natural Sciences, Lebanese American University, Beirut, Lebanon Background: Topotecan (TP) is an anticancer drug acting as topoisomerase I inhibitor that ...
Abi Raad S +4 more
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Immediate Versus Delayed Topotecan after First-line Therapy in Small Cell Lung Cancer
Chinese Journal of Lung Cancer, 2010 Background and objective How to prolong progression free survival (PFS) and overall survival (OS) of patients with small cell lung cancer (SCLC) has been one of the hottest issues. We retrospectively reviewed our data to compare the survival of immediate
Cong XUE +7 more
doaj
, 1999 PURPOSE: Topotecan and cyclophosphamide, doxorubicin, and vincristine (CAV) were evaluated in a randomized, multicenter study of patients with small-cell lung cancer (SCLC) who had relapsed at least 60 days after completion of first-line therapy ...
J.P. Kleisbauer +14 more
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Loading profile of topotecan into polyvinyl alcohol microspheres (DC Bead™) over a 7-day period
, 2011 Purpose: DC Bead™ is successfully used for chemoembolization of various liver cancers. The purpose of this study was todetermine the loading capacity of the semi-synthetic topoisomerase-1 inhibitor topotecan into the DC Bead™ microspheres under static ...
Irene Krämer, Jeanette Kaiser
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A study of variable hydration states in topotecan hydrochloride
, 2006 Topotecan hydrochloride, a pharmaceutical compound developed as a treatment for cancer, exhibits variable hydration states in a crystalline solid form chosen for manufacturing. This variability requires additional controls for successful development, and
Frederick G Vogt +9 more
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