Results 21 to 30 of about 17,823 (170)

DNA repair and cholesterol-mediated drug efflux induce dose-dependent chemoresistance in nutrient-deprived neuroblastoma cells

iScience, 2021
Summary: Neuroblastoma is a solid, heterogeneous pediatric tumor. Chemotherapy is widely used to treat neuroblastoma. However, dose-dependent responses and chemoresistance mechanisms of neuroblastoma cells to anticancer drugs remain challenging. Here, we
Soo Yeon Chae, Dowoon Nam, Do Young Hyeon, Areum Hong, Timothy Dain Lee, Sujin Kim, Dongjoon Im, Jiwon Hong, Chaewon Kang, Ji Won Lee, Daehee Hwang, Sang-Won Lee, Hugh I. Kim   +12 more
doaj   +1 more source

Inhalation delivery dramatically improves the efficacy of topotecan for the treatment of local and distant lung cancer

Drug Delivery, 2021
Topotecan is potent anti-cancer drug approved for various malignancies but hematopoietic toxicities undermine its wider application and use of its most effective dose. This study aims to improve these limitations through inhalation-delivery.
Philip J. Kuehl, Christin M. Yingling, Devon Dubose, Michael Burke, David A. Revelli, Wenshu Chen, Wendy W. Dye, Steven A. Belinsky, Mathewos Tessema   +8 more
doaj   +1 more source

The Lipophilic Purine Nucleoside—Tdp1 Inhibitor—Enhances DNA Damage Induced by Topotecan In Vitro and Potentiates the Antitumor Effect of Topotecan In Vivo

Molecules, 2022
The use of cancer chemotherapy sensitizers is a promising approach to induce the effect of clinically used anticancer treatments. One of the interesting targets is Tyrosyl-DNA Phosphodiesterase 1 (Tdp1), a DNA-repair enzyme, that may prevent the action ...
Irina A. Chernyshova, Aleksandra L. Zakharenko, Nikolay N. Kurochkin, Nadezhda S. Dyrkheeva, Tatyana E. Kornienko, Nelly A. Popova, Valeriy P. Nikolin, Ekaterina S. Ilina, Timofey D. Zharkov, Maxim S. Kupryushkin, Vladimir E. Oslovsky, Mikhail S. Drenichev, Olga I. Lavrik   +12 more
doaj   +1 more source

Evaluation of The Effect of Topotecan, Carvacrol, Epigallocatechin Gallate and Their Combination on Apoptotic Process in Neuroblastoma and Astrocyte Cells

, 2023
Neuroblastoma is a sympathetic nervous system cancer. Neuroblastoma most commonly affects children under five years of age and is the most common solid tumor in childhood. Topotecan is a topoisomerase 1 inhibitor.
Akıncı, Melek, Oltulu, Çağatay, Bakar, Elvan, Akinci, Melek   +3 more
core   +2 more sources

A phase I and pharmacokinetic study of intraperitoneal topotecan [PDF]

, 2001
Purpose: To evaluate the feasibility and pharmacology of intraperitoneal (IP) topotecan. Patients and methods: Fifteen patients with recurrent ovarian cancer in a phase I trial were treated with escalating IP topotecan doses (5-30 mg/m(2)) for ...
van der Zee, AGJ, Beijnen, JH, A M E Bos, N H Mulder, L S Hofstra, P H B Willemse, Rosing, H, A G J van der Zee, de Vries, EGE; id_orcid, Hofstra, LS, Willemse, PHB, de Vries, EGE, J H Beijnen, J G Aalders, Mulder, NH, Aalders, JG, E G E de Vries, H Rosing   +17 more
core   +5 more sources

Comparison of the second-line treatments for patients with small cell lung cancer sensitive to previous platinum-based chemotherapy: A systematic review and Bayesian network analysis

Frontiers in Oncology, 2023
ObjectiveIt remains unclear what the best second-line treatment is for patients with small-cell lung cancer sensitive to previous platinum-based chemotherapy.MethodsWe systematically screened randomized controlled trials from several online databases ...
Hekai Shi, Nuojin Guo, Zeming Zhao, Ligang Liu, Tianyi Ni, Jinye Zhang, Yingjie Lu   +6 more
doaj   +1 more source

Exploration of the intercellular heterogeneity of topotecan uptake into human breast cancer cells through compartmental modelling [PDF]

, 2008
A mathematical multi-cell model for the in vitro kinetics of the anti-cancer agent topotecan (TPT) following administration into a culture medium containing a population of human breast cancer cells (MCF-7 cell line) is described.
Chappell, M. J. (Michael J.), Godfrey, Keith, Godfrey, K. R., Evans, Neil D., Cheung, S. Y. Amy, Errington, Rachel J., Cheung, S. Y. A., Errington, Rachel Jane, Smith, Paul J., Evans, N. D., Smith, Paul James, Chappell, M. J.   +11 more
core   +1 more source

OUR EXPERIENCE WITH TOPOTECAN AS SECOND- LINE TREATMENT OF PATIENTS WITH RELAPSED SMALL CELL LUNG CANCER [PDF]

Journal of IMAB, 2010
Objectives: Single agent intravenous Topotecan is an effective treatment for small cell lung cancer /SCLC/ after failure of first- line chemotherapy. The aim of this study was to evaluate the efficacy and toxicity of intravenous Topotecan in recurrent ...
Deyan Davidov
doaj   +1 more source

Continuous and bolus intraventricular topotecan prolong survival in a mouse model of leptomeningeal medulloblastoma.

PLoS ONE, 2019
Leptomeningeal metastasis remains a difficult clinical challenge. Some success has been achieved by direct administration of therapeutics into the cerebrospinal fluid (CSF) circumventing limitations imposed by the blood brain barrier.
Gregory M Shackleford, Min Y Mahdi, Rex A Moats, Debra Hawes, Hung C Tran, Jonathan L Finlay, Tuan Q Hoang, Ellis F Meng, Anat Erdreich-Epstein   +8 more
doaj   +1 more source

Systematic Review of topotecan (Hycamtin) in relapsed small cell lung cancer

BMC Cancer, 2010
Background To undertake a systematic review of the available data for oral and intravenous topotecan in adults with relapsed small cell lung cancer (SCLC) for whom re-treatment with the first line regimen is not considered appropriate.
Riemsma Rob, Simons Jean P, Bashir Zahid, Gooch Caroline L, Kleijnen Jos   +4 more
doaj   +1 more source