Results 81 to 90 of about 17,638 (200)

Establishment and Characterization of a Topotecan Resistant Non-small Cell Lung Cancer NCI-H460/TPT10 Cell Line

Frontiers in Cell and Developmental Biology, 2020
While topotecan (TPT) is a first- and second-line chemotherapeutic drug in treating lung cancer, the development of drug resistance in tumors still reserves as a major obstacle to chemotherapeutic success.
Zi-Ning Lei, Qiu-Xu Teng, Wei Zhang, Wei Zhang, Ying-Fang Fan, Ying-Fang Fan, Jing-Quan Wang, Chao-Yun Cai, Kimberly W. Lu, Kimberly W. Lu, Dong-Hua Yang, John N. D. Wurpel, Zhe-Sheng Chen   +12 more
doaj   +1 more source

Rechallenge With Immunotherapy for ES‐SCLC: Efficacy and Safety From a Retrospective Propensity Score‐Matched Study

Cancer Medicine, Volume 15, Issue 9, September 2026.
ABSTRACT Background Although immunotherapy combined with platinum‐based chemotherapy is now the standard first‐line treatment for extensive‐stage small cell lung cancer (ES‐SCLC), the benefit of continuing immune checkpoint inhibitors (ICIs) after disease progression (PD) remains uncertain.
Yuxia Wang, Yunfeng Tong, Yang Pan, Xinyue Li, Hui Li   +4 more
wiley   +1 more source

Berzosertib Plus Topotecan vs Topotecan Alone in Patients With Relapsed Small Cell Lung Cancer: A Randomized Clinical Trial

, 2023
Patients with relapsed small cell lung cancer (SCLC), a high replication stress tumor, have poor prognoses and few therapeutic options. A phase 2 study showed antitumor activity with the addition of the ataxia telangiectasia and Rad3-related kinase ...
Pachecho, Jose M, Ruiz, Jimmy, Malin, Justin, Nieva, Jorge, Gore, Steven D, Desai, Parth, Pinkiert, Danielle, Vilimas, Rasa, Shum, Elaine, Pommier, Yves, Steinberg, Seth M, Chauhan, Aman, Upadhyay, Deep, Redon, Christophe E, Shimellis, Hirity, Takahashi, Nobuyuki, Krishnamurthy, Manan, Nichols, Samantha, Schroeder, Brett, Goyal, Shubhank, Sharma, Ajit Kumar, Petty, W Jeffrey, Abel, Melissa, Kumar, Rajesh, Sciuto, Linda, Graham, Chante, Schultz, Christopher W, Villaruz, Liza C, Kattappuram, Robbie, Aladjem, Mirit I, Hao, Zhonglin, Riess, Jonathan W, Zhang, Jun, Fuld, Alexander D, Shelat, Meenakshi, Thomas, Anish, Mamdani, Hirva, McGlone, Jessie   +37 more
core   +1 more source

Copper-topotecan complexation : development of a novel liposomal fromulation of topotecan

, 2006
Previously it has been reported that transition metal complexation reactions can be used as a method to encapsulate the anticancer drug doxorubicin into liposomes.
Taggar, Amandeep S.
core   +1 more source

Pharmacokinetic Comparison of Three Different Administration Routes for Topotecan Hydrochloride in Rats

Pharmaceuticals, 2020
Topotecan is actively used in clinic, with its primary use being in treatment of various types of cancer. The approved administration routes are oral and intravenous.
Seung-Hyun Jeong, Ji-Hun Jang, Yong-Bok Lee   +2 more
doaj   +1 more source

Topotecan and Ginkgolic Acid Inhibit the Expression and Transport Activity of Human Organic Anion Transporter 3 by Suppressing SUMOylation of the Transporter

Pharmaceutics
Organic anion transporter 3 (OAT3), expressed at the basolateral membrane of kidney proximal tubule cells, facilitates the elimination of numerous metabolites, environmental toxins, and clinically important drugs.
Zhou Yu, Guofeng You
doaj   +1 more source

Augmenting tumor sensitivity to topotecan by transient hypoxia

, 2005
We examined how the effect of topotecan is modulated by transient hypoxia in three different tumor lines, Lewis lung carcinoma (LLC), U87 human glioblastoma and DMS273 human small cell lung cancer.
Lund, Eva L., Hansen, Lasse T., Kristjansen, Paul E.G.   +2 more
core   +1 more source

Development and Validation of an HPLC Method for Analysis of Topotecan in Human Cerebrospinal Fluid and Its Application in Elimination Evaluation of Topotecan after Intraventricular Injection

, 2021
Intrathecal administration of anticancer drugs is an effective dosage strategy, but the elimination of intraventricular drugs is not uniform in all patients.
Mariko Kinoshita, Naoki Yoshikawa, Ryuji Ikeda, Hiroshi Moritake, Tsubasa Yokota, Ai Yamada, Yusei Yamada   +6 more
core   +1 more source

Phase I dose escalation study of vinorelbine and topotecan combination chemotherapy in patients with recurrent lung cancer

BMC Cancer, 2007
Background A platinum doublet is the current standard treatment for good performance status patients with advanced non-small cell lung cancer (NSCLC) and extensive stage small cell lung cancer (SCLC) with good performance status.
Kraft Andrew S, Meyer Mario L, Chaudhary Uzair, Garrett-Mayer Elizabeth, Green Mark R, Sherman Carol A, Beldner Matthew A, Montero Alberto J   +7 more
doaj   +1 more source

Determination of Topotecan by ELISA.

Biological and Pharmaceutical Bulletin, 2001
A highly sensitive ELISA for the determination of (s)-9-dimethylaminomethyl-10-hydroxy-camptothecin (topotecan) capable of measuring as low as 80 pg/ml was developed. Anti-topotecan antibody was obtained by immunizing rabbits with topotecan conjugated with bovine serum albumin using diazotized m-aminobenzoic acid as a cross-linker.
SAITA, Tetsuya, FUJITO, Hiroshi, MORI, Masato   +2 more
openaire   +3 more sources