Results 31 to 40 of about 25,691 (210)
In Vitro Chemosensitivity Using the Histoculture Drug Response Assay in Human Epithelial Ovarian Cancer [PDF]
, 2012 The choice of chemotherapeutic drugs to treat patients with epithelial ovarian cancer has not depended on individual patient characteristics. We have investigated the correlation between in vitro chemosensitivity, as determined by the histoculture drug ...
Kim, Dae-Yeon +6 more
core +1 more source
Canadian Respiratory Journal, 2016 Purpose. Topotecan and belotecan are camptothecin derivatives that are used to treat small cell lung cancer (SCLC). This study compared the toxicities and efficacies of belotecan and topotecan monotherapies in patients with SCLC. Methods.
Yeon Hee Park +11 more
doaj +1 more source
Frontiers in Oncology, 2019 The purpose of this study was to examine pazopanib/topotecan combination activity vs. pazopanib monotherapy on anaplastic thyroid cancer (ATC) cells.
Teresa Di Desidero +3 more
doaj +1 more source
Repeating platinum/bevacizumab in recurrent or progressive cervical cancer yields marginal survival benefits [PDF]
, 2017 Our objective was to assess overall survival of cervical cancer patients following prior platinum/bevacizumab chemotherapy, comparing retreatment with platinum/bevacizumab with alternative therapies.
Massad, L. Stewart +3 more
core +3 more sources
Drug Delivery, 2018 Intravenous (IV) topotecan is approved for the treatment of various malignancies including lung cancer but its clinical use is greatly undermined by severe hematopoietic toxicity. We hypothesized that inhalation delivery of topotecan would increase local
Philip J. Kuehl +7 more
doaj +1 more source
HIF inhibitor topotecan has a neuroprotective effect in a murine retinal ischemia-reperfusion model [PDF]
PeerJ, 2019 Purpose The therapeutic approach for retinal ganglion cell (RGC) degeneration has not been fully established. Recently, it has been reported that hypoxia-inducible factor (HIF) may be involved with retinal neurodegeneration.
Hiromitsu Kunimi +4 more
doaj +2 more sources
BMC Cancer, 2012 Background Despite aggressive multimodal treatments the overall survival of patients with high-risk neuroblastoma remains poor. The aim of this study was to identify novel combination chemotherapy to improve survival rate in patients with high-risk ...
Tsang Patricia S +6 more
doaj +1 more source
Topoisomerase 1 Regulates Gene Expression in Neurons through Cleavage Complex-Dependent and -Independent Mechanisms. [PDF]
PLoS ONE, 2016 Topoisomerase 1 (TOP1) inhibitors, including camptothecin and topotecan, covalently trap TOP1 on DNA, creating cleavage complexes (cc's) that must be resolved before gene transcription and DNA replication can proceed.
Angela M Mabb +6 more
doaj +1 more source
Topotecan Delivery to the Optic Nerve after Ophthalmic Artery Chemosurgery. [PDF]
PLoS ONE, 2016 Extraocular retinoblastoma is a major challenge worldwide, especially in developing countries. Current treatment involves the administration of systemic chemotherapy combined with radiation, but there is a clear need for improvement of chemotherapy ...
Paula Taich +7 more
doaj +1 more source
Pharmaceutics, 2022 Transscleral diffusion delivery of chemotherapy is a promising way to reach the vitreal seeds of retinoblastoma, the most common intraocular malignancy in childhood.
Martina Kodetova +11 more
doaj +1 more source