Results 41 to 50 of about 22,889 (244)

Synthetic Lethal Screen Identifies NF-κB as a Target for Combination Therapy with Topotecan for patients with Neuroblastoma

BMC Cancer, 2012
Background Despite aggressive multimodal treatments the overall survival of patients with high-risk neuroblastoma remains poor. The aim of this study was to identify novel combination chemotherapy to improve survival rate in patients with high-risk ...
Tsang Patricia S, Cheuk Adam T, Chen Qing-Rong, Song Young K, Badgett Thomas C, Wei Jun S, Khan Javed   +6 more
doaj   +1 more source

Topoisomerase 1 Regulates Gene Expression in Neurons through Cleavage Complex-Dependent and -Independent Mechanisms. [PDF]

PLoS ONE, 2016
Topoisomerase 1 (TOP1) inhibitors, including camptothecin and topotecan, covalently trap TOP1 on DNA, creating cleavage complexes (cc's) that must be resolved before gene transcription and DNA replication can proceed.
Angela M Mabb, Jeremy M Simon, Ian F King, Hyeong-Min Lee, Lin-Kun An, Benjamin D Philpot, Mark J Zylka   +6 more
doaj   +1 more source

Enhancement of the Antitumor and Antimetastatic Effect of Topotecan and Normalization of Blood Counts in Mice with Lewis Carcinoma by Tdp1 Inhibitors—New Usnic Acid Derivatives

International Journal of Molecular Sciences
Tyrosyl-DNA phosphodiesterase 1 (Tdp1) is an important DNA repair enzyme and one of the causes of tumor resistance to topoisomerase 1 inhibitors such as topotecan.
T. E. Kornienko, A. Chepanova, A. Zakharenko, A. Filimonov, O. Luzina, N. Dyrkheeva, V. Nikolin, N. A. Popova, N. Salakhutdinov, O. Lavrik   +9 more
semanticscholar   +1 more source

Inhibition of Poly(ADP-Ribose) polymerase enhances the toxicity of 131I-Metaiodobenzylguanidine/Topotecan combination therapy to cells and xenografts that express the noradrenaline transporter

, 2012
Targeted radiotherapy using [131I]meta-iodobenzylguanidine ([131I]MIBG) has produced remissions in some neuroblastoma patients. We previously reported that combining [131I]MIBG with the topoisomerase I (Topo-I) inhibitor topotecan induced long-term DNA ...
Babich, J.W., Champion, S., Babich, John W, Mairs, Robert J, Gaze, Mark N, Tesson, Mathias, McCluskey, Anthony G, Champion, Sue, Mairs, R.J., McCluskey, A.G., Gaze, M.N., Pimlott, S.L., Boyd, Marie, Tesson, M., Boyd, M., Pimlott, Sally L   +15 more
core   +1 more source

Topotecan Delivery to the Optic Nerve after Ophthalmic Artery Chemosurgery. [PDF]

PLoS ONE, 2016
Extraocular retinoblastoma is a major challenge worldwide, especially in developing countries. Current treatment involves the administration of systemic chemotherapy combined with radiation, but there is a clear need for improvement of chemotherapy ...
Paula Taich, Flavio Requejo, Marcelo Asprea, Mariana Sgroi, Pierre Gobin, David H Abramson, Guillermo Chantada, Paula Schaiquevich   +7 more
doaj   +1 more source

A randomised phase 2b study comparing the efficacy and safety of belotecan vs. topotecan as monotherapy for sensitive-relapsed small-cell lung cancer

British Journal of Cancer, 2020
This study compared the efficacy/safety of the camptothecin analogues belotecan and topotecan for sensitive-relapsed small-cell lung cancer (SCLC). One-hundred-and-sixty-four patients were randomised (1:1) to receive five consecutive daily intravenous ...
Jin-Hyoung Kang, K. Lee, Dong-Wan Kim, Sang-We Kim, H. R. Kim, Joo‐Hang Kim, Jin-Hyuk Choi, H. An, Jin-Soo Kim, J. Jang, Bongseog Kim, Heung Tae Kim   +11 more
semanticscholar   +1 more source

Is Intravitreal Topotecan Toxic to Retinal Function?

British Journal of Ophthalmology, 2020
Background Intravitreal injections of topotecan are used in the management of retinoblastoma with vitreous seeds. This study evaluated whether intravitreal topotecan was associated with retinal toxicity.
Jennifer B Nadelmann, J. Francis, S. Brodie, Engjel Muca, D. Abramson   +4 more
semanticscholar   +1 more source

Intravitreal topotecan inhibits laser-induced choroidal neovascularization in a rat model

Journal of Ophthalmic & Vision Research, 2015
Purpose: A two-phase preclinical study was designed to determine the safe dose of intravitreal topotecan and its inhibitory effect on experimental choroidal neovascularization (CNV) in a rat model.
Mohammad Ali Gholipour, Mozhgan Rezaei Kanavi, Hamid Ahmadieh, Seyed Javid Aldavood, Ramin Nourinia, Seyed Bagher Hosseini, Narsis Daftarian, Ebrahim Mohammad Nashtaei, Adib Tousi, Sare Safi   +9 more
doaj   +1 more source

TME/NIR Dual‐Responsive Zinc‐Based Targeted Nanoagonist for Multimodal Amplification of STING‐Mediated Cancer Immunotherapy

Advanced Science, EarlyView.
A multifunctional nanoagonist (cDZ@IP) enables nano‐metabolite–driven multimodal activation of the STING pathway and enhanced immune recognition, achieving potent antitumor immunity and suppressing tumor growth and metastasis. This strategy highlights the rational design of therapeutic metabolites and establishes a new paradigm bridging nanomedicine ...
Kepeng Hu, Jiawei Wang, Wei Zhang, Zhixuan Wu, Jing Chen, Yujing He, Xiyue Duan, Yaoting He, Xin Xin, Haoyi Xiang, Yijing Wang, Chengwei Wu, Yang Yi, Qing Meng, Yuqian Qiao, Kui Cheng, Xiaojun Long, Zhangfa Song   +17 more
wiley   +1 more source

Hyaluronic acid–targeted topotecan liposomes improve therapeutic efficacy against lung cancer in animals

Frontiers in Oncology
Lung cancer, as a serious threat to human health and life, necessitating urgent treatment and intervention. In this study, we prepared hyaluronic acid (HA)-targeted topotecan liposomes for site-specific delivery to tumor cells.
Gangqiang Xue, Lu Tang, Xinyan Pan, Sanni Li, Juan Zhao   +4 more
doaj   +1 more source