Results 61 to 70 of about 22,889 (244)

Identification of Novel Therapeutic Agent Candidates Through High Throughput Screening With Chemical Library Based on Molecular Subclassification in Canine Histiocytic Sarcoma Cell Lines

Veterinary and Comparative Oncology, EarlyView.
ABSTRACT Effective chemotherapy for canine histiocytic sarcoma (CHS) has yet to be established. In our previous study, CHS cell lines were subclassified into two groups based on their gene expression profiles: Group A and Group B. This study aimed to identify novel therapeutic agents that are effective against each CHS subgroup, and we performed high ...
Hiroki Sakuma, Hirotaka Tomiyasu, Mari Takamiya, Yuko Goto‐Koshino, Atsushi Tsukamoto, Makoto Bonkobara, Masaru Okuda   +6 more
wiley   +1 more source

Phase I Study of ATR Inhibitor M6620 in Combination With Topotecan in Patients With Advanced Solid Tumors.

Journal of Clinical Oncology, 2017
Purpose Our preclinical work identified depletion of ATR as a top candidate for topoisomerase 1 (TOP1) inhibitor synthetic lethality and showed that ATR inhibition sensitizes tumors to TOP1 inhibitors.
Anish Thomas, C. Redon, L. Sciuto, Emerson B Padiernos, J. Ji, Min-Jung Lee, Akira Yuno, Sunmin Lee, Yiping Zhang, Lan T. Tran, W. Yutzy, A. Rajan, U. Guha, Haobin Chen, R. Hassan, C. Alewine, E. Szabo, S. Bates, R. Kinders, S. Steinberg, J. Doroshow, M. Aladjem, J. Trepel, Y. Pommier   +23 more
semanticscholar   +1 more source

IVT topotecan prolongs survival of mice with leptomeningeal D425 medulloblastoma compared to bolus IP topotecan.

, 2019
Kaplan-Meier survival curves of mouse groups are shown. (A) comparison of all groups. (B) Daily IP topotecan versus daily IP saline control. (C) Daily IP topotecan, daily IVT topotecan, or continuous IVT topotecan infusion via pump.
Ellis F. Meng (6175520), Min Y. Mahdi (2838335), Tuan Q. Hoang (6175517), Rex A. Moats (370209), Anat Erdreich-Epstein (312560), Debra Hawes (20923), Hung C. Tran (6175511), Jonathan L. Finlay (6175514), Gregory M. Shackleford (2838326)   +8 more
core   +1 more source

Topotecan for ovarian cancer [PDF]

Cochrane Database of Systematic Reviews, 2008
Chemotherapeutic agents such as topotecan can be used to treat ovarian cancer. The effects of using topotecan as a therapeutic agent have not been previously been systematically reviewed.To systematically evaluate the effectiveness and safety of topotecan for the treatment of ovarian cancer.We searched the Cochrane Central Register of Controlled Trials
Minawaer Abudou, Dake Zhong, Taixiang Wu, XiaoKe Wu   +3 more
openaire   +2 more sources

Treatment patterns and clinical outcomes in real‐world patients with small‐cell lung cancer in South Korea: A single‐center experience

International Journal of Cancer, Volume 159, Issue 3, Page 719-728, 1 August 2026.
What's New? The emerging role of immunotherapy in small‐cell lung cancer treatment has not been fully elucidated, particularly outside of clinical trials. This single‐center retrospective cohort study examined real‐world treatment patterns and overall survival in South Korea during the 2018–2023 period.
Sehhoon Park, Danbee Kang, Jin Lee, Hyun Ae Jung, Jong‐Mu Sun, Se‐Hoon Lee, Jin Seok Ahn, Hojoon Lee, Hyuna Lim, Xerxes Pundole, Juhee Cho, Myung‐Ju Ahn   +11 more
wiley   +1 more source

Mechanism-based models for topotecan-induced neutropenia

, 2004
OBJECTIVE: A semiphysiologic pharmacokinetic-pharmacodynamic model was applied to describe topotecan-induced neutropenia, to quantify interindividual and intraindividual pharmacodynamic variability, and to study the effect of covariates on the model ...
Bugat, R, Chatelut, Etienne, Léger, Frédéric, Mathijssen, Ron H J; id_orcid, Goffinet, Marine, Bugat, Roland, Verweij, Jaap, Loos, Walter, Sparreboom, Alex, Goffinet, M, Léger, F, Sparreboom, A, Loos, Walter J, Mathijssen, RHJ, Chatelut, E   +14 more
core   +1 more source

A simulated trial with reinforcement learning for the efficacy of Irinotecan and Ifosfamide versus Topotecan in relapsed, extensive stage small cell lung cancer

BMC Cancer
Objectives Synthetic data may proxy clinical data. At the absence of direct clinical data, this study aimed to compare Irinotecan and Ifosfamide (II) with Topotecan in synthetic, recurrent small cell lung cancer (SCLC) patients within a simulated ...
Hakan Şat Bozcuk, Mehmet Artaç
doaj   +1 more source

Topoisomerase I inhibitors, shikonin and topotecan, inhibit growth and induce apoptosis of glioma cells and glioma stem cells.

PLoS ONE, 2013
Gliomas, the most malignant form of brain tumors, contain a small subpopulation of glioma stem cells (GSCs) that are implicated in therapeutic resistance and tumor recurrence.
Feng-Lei Zhang, Ping Wang, Yun-Hui Liu, Li-Bo Liu, Xiao-Bai Liu, Zhen Li, Yi-Xue Xue   +6 more
doaj   +1 more source

Schedule-Dependent Antiangiogenic and Cytotoxic Effects of Chemotherapy on Vascular Endothelial and Retinoblastoma Cells. [PDF]

PLoS ONE, 2016
Current treatment of retinoblastoma involves using the maximum dose of chemotherapy that induces tumor control and is tolerated by patients. The impact of dose and schedule on the cytotoxicity of chemotherapy has not been studied.
Ursula Winter, Hebe A Mena, Soledad Negrotto, Eloisa Arana, Guillem Pascual-Pasto, Viviana Laurent, Mariona Suñol, Guillermo L Chantada, Angel M Carcaboso, Paula Schaiquevich   +9 more
doaj   +1 more source

Lactone Stabilized by Crosslinked Cyclodextrin Metal-Organic Frameworks to Improve Local Bioavailability of Topotecan in Lung Cancer

Pharmaceutics, 2022
The protection of unstable anticancer molecules and their delivery to lesions are challenging issues in cancer treatment. Topotecan (TPT), a classic cytotoxic drug, is widely used for treating refractory lung cancer.
Ting Xiong, Tao Guo, Yaping He, Zeying Cao, Huipeng Xu, Wenting Wu, Li Wu, Weifeng Zhu, Jiwen Zhang   +8 more
doaj   +1 more source