Results 51 to 60 of about 22,889 (244)
EZN-2208 (PEG-SN38) overcomes ABCG2-mediated topotecan resistance in BRCA1-deficient mouse mammary tumors. [PDF]
PLoS ONE, 2012 BRCA1 dysfunction in hereditary breast cancer causes defective homology-directed DNA repair and sensitivity towards DNA damaging agents like the clinically used topoisomerase I inhibitors topotecan and irinotecan.
Serge A L Zander +7 more
doaj +1 more source
Investigation of Topotecan and Folic Acid Effect in Jar Choriocarcinoma Cell Culture
Batı Karadeniz Tıp Dergisi, 2021 Aim: The purpose of this study is to search the effects and treatment efficacies of topotecan and folicacid on the choriocarcinoma cultures generated in JAR cell culture.Material and Methods: Human choriocarcinoma-like JAR cell is augmented in the 10 ...
Rahşan Eyüp Doğan +5 more
doaj +1 more source
International Journal of Cancer, EarlyView.The detection of tumor‐infiltrating lymphocytes (TILs) is a positive prognostic factor in ovarian cancer. Moreover, TILs are significantly boosted by immunotherapy, though ovarian cancer patients have seen limited benefit from immune therapies. This study investigated the safety and feasibility of TIL therapy combined with PD‐1 and LAG‐3 inhibitors in ...
Tine J. Monberg +9 more
wiley +1 more source
Future Oncology, 2019 Lurbinectedin is an inhibitor of active transcription of protein-coding genes, causing DNA-break accumulation, apoptosis and modulation of the tumor microenvironment.
A. Farago +6 more
semanticscholar +1 more source
Optimization of liposomal topotecan for use in treating neuroblastoma [PDF]
, 2017 The purpose of this work was to develop an optimized liposomal formulation of topotecan for use in the treatment of patients with neuroblastoma. Drug exposure time studies were used to determine that topotecan (Hycamtin) exhibited great cytotoxic ...
Gilabert-Oriol, R +5 more
core +1 more source
Bevacizumab‐Associated Eczema Herpeticum in Metastatic Ovarian Carcinoma: A Case Report
JEADV Clinical Practice, EarlyView.ABSTRACT Eczema herpeticum (EH) is a rare but potentially life‐threatening cutaneous infection caused by herpes simplex virus (HSV), classically associated with atopic dermatitis. Its occurrence in oncology patients receiving anti‐angiogenic targeted therapy and cytotoxic chemotherapy is exceedingly uncommon.
Mandeep Dutta Joshi +6 more
wiley +1 more source
British Journal of Cancer, 2020 This Phase 2b study compared the efficacy and toxicity of belotecan and topotecan in recurrent ovarian cancer. Patients with platinum-sensitive recurrent or platinum-resistant recurrent ovarian cancer (PRROC) were randomised 1:1 to receive belotecan 0.5 ...
H. Kim +10 more
semanticscholar +1 more source
Traditional Chinese Medicine for lung cancer: Mechanisms, clinical evidence, and future perspectives
Precision Medical Sciences, EarlyView.Graphical abstract represents the risk factors for lung cancer, TCM efficacy and clinical outcomes to future challenges. Abstract Lung cancer remains a leading cause of global cancer mortality. Despite advances in conventional treatments such as surgery, chemotherapy, targeted therapy, and immunotherapy, challenges including drug resistance, toxicity ...
Zhangdeng Chen, Liujun Bao
wiley +1 more source
Interventional oncology in children: Where are we now?
Journal of Medical Imaging and Radiation Oncology, EarlyView.Abstract Paediatric Interventional Oncology (IO) lags behind adult IO due to a scarcity of specific outcome data. The suboptimal way to evolve this field is relying heavily on adult experiences. The distinct tumour types prevalent in children, such as extracranial germ cell tumours, sarcomas, and neuroblastoma, differ strongly from those found in ...
Premal Amrishkumar Patel +1 more
wiley +1 more source
Parasites & Vectors, 2021 Background The evolution of drug resistance is one of the biggest challenges in leishmaniasis and has prompted the need for new antileishmanial drugs.
Chloé Rosa-Teijeiro +6 more
doaj +1 more source