Results 171 to 180 of about 41,306 (245)

Fenfluramine in SCN1A‐related GEFS+: A multicenter observational study on efficacy, EEG improvement, and tolerability

Epilepsia Open, Volume 11, Issue 2, Page 619-626, April 2026.
Abstract The SCN1A gene is implicated in a broad spectrum of epilepsy phenotypes, ranging from self‐limited genetic epilepsy with febrile seizures plus (GEFS+) to severe developmental and epileptic encephalopathies such as Dravet syndrome (DS). While fenfluramine (FFA) has demonstrated strong efficacy in DS, its role in SCN1A‐related epilepsies beyond ...
Giovanni B. Dell'Isola, Alice Muda, Lucio Giordano, Renzo Guerrini, Alessandra Boncristiano, Nicola Pietrafusa, Maria Polselli, Francesca Bisulli, Francesca Ragona, Antonella Riva, Pasquale Striano, Domenica Immacolata Battaglia, Federico Vigevano   +12 more
wiley   +1 more source

Metabolite-mediated TOR signaling regulates the circadian clock in Arabidopsis. [PDF]

Proc Natl Acad Sci U S A, 2019
Zhang N, Meng Y, Li X, Zhou Y, Ma L, Fu L, Schwarzländer M, Liu H, Xiong Y.   +8 more
europepmc   +1 more source

Vestibular Evoked Myogenic Potentials to Diagnose Vestibular Neuritis: A Scoping Review

The Laryngoscope, Volume 136, Issue 4, Page 1635-1644, April 2026.
Standardization of stimulation and recording protocols is essential to improve comparability across VEMP studies. Integrating cervical and ocular VEMPs with other vestibular tests enhances diagnostic accuracy and supports precise localization of vestibular neuritis.
Diego Piatti, Laura Casagrande Conti, Gianluca Paolocci, Iole Indovina, Marco Tramontano, Leonardo Manzari   +5 more
wiley   +1 more source

What If Each Voxel Were Measured With a Different Diffusion Protocol?

Magnetic Resonance in Medicine, Volume 95, Issue 4, Page 2277-2290, April 2026.
ABSTRACT Purpose Expansion of diffusion MRI (dMRI) both into the realm of strong gradients and into accessible imaging with portable low‐field devices brings about the challenge of gradient nonlinearities. Spatial variations of the diffusion gradients make diffusion weightings and directions non‐uniform across the field of view, and deform perfect ...
Santiago Coelho, Gregory Lemberskiy, Ante Zhu, Hong‐Hsi Lee, Nastaren Abad, Thomas K. F. Foo, Els Fieremans, Dmitry S. Novikov   +7 more
wiley   +1 more source

Engineering Yeast Extracellular Vesicle Biogenesis Through Rewiring Membrane Trafficking Pathways

Microbial Biotechnology, Volume 19, Issue 4, April 2026.
Engineered Saccharomyces cerevisiae reveals how cell wall remodelling and membrane trafficking coordinate extracellular vesicle biogenesis. Interferon overexpression and chs3 deletion enhance EV secretion and reshape SNARE‐, Rab‐ and ESCRT‐associated pathways, establishing yeast as a versatile platform for EV engineering and therapeutic cargo loading ...
Yueyan Li, XiaoRan Ma, Lichao Zhang, Ning Cao, Zhibo Li, Ruixin Khoo, Mei Wang, Changyan Li, Deping Hua, Xintian Zheng, Jinhai Huang, Lilin Zhang   +11 more
wiley   +1 more source

Effects of supplementing coated methionine in a high plant-protein diet on growth, antioxidant capacity, digestive enzymes activity and expression of TOR signaling pathway associated genes in gibel carp, Carassius auratus gibelio. [PDF]

Front Immunol
Du Y, Lin X, Shao X, Zhao J, Xu H, de Cruz CR, Xu Q.   +6 more
europepmc   +1 more source

Autophagy‐Independent Function of ATG‐18 Is Essential for Gonadal Longevity in Caenorhabditis elegans

Aging Cell, Volume 25, Issue 4, April 2026.
Neuronal and intestinal ATG‐18 promote longevity conferred by germline removal in C. elegans via non‐autophagic functions. In the intestine, ATG‐18 regulates lifespan through its interaction with the gluconeogenic enzyme PCK‐2. ABSTRACT Autophagy, a highly conserved cellular degradation process, plays essential roles in various physiological processes ...
Tatsuya Shioda, Ittetsu Takahashi, Makoto Horikawa, Taiichi Osumi, Takayuki Shima, Akiyo Yamauchi, Kayo Nakamura, Taeko Sasaki, Tatsuya Kaminishi, Harunori Yoshikawa, Miyuki Sato, Hidetaka Kosako, Tamotsu Yoshimori, Shuhei Nakamura   +13 more
wiley   +1 more source

Novel Silver(I) and Gold(I) N‐Heterocyclic Carbene Complexes Induce ROS‐Dependent Autophagic Cell Death in Human Hepatoma Cell Line HepG2

Chemical Biology &Drug Design, Volume 107, Issue 4, April 2026.
In this research work, the cytotoxicity of eight sulfonated silver(I) and gold(I) N‐heterocyclic carbene (NHC) complexes—four newly synthesized—was evaluated against human liver cancer cells. Two compounds showed selectivity for cancer cells, inducing ROS‐dependent autophagic cell death via AKT/mTOR pathway inhibition without triggering apoptosis ...
Rocchina Miglionico, Francesco Viceconte, Maria Francesca Armentano, Annaluisa Mariconda, Ilaria Nigro, Pasquale Longo, Faustino Bisaccia   +6 more
wiley   +1 more source

TOR Signaling in Budding Yeast

, 2018
Inoue, Yoshiharu, Nomura, Wataru
openaire   +3 more sources

Connecting the Dots: Does COI Variability in Paramecium caudatum (Ciliates, Protista) Support the Moderate Endemicity Model of Microeukaryote Distribution?

Journal of Biogeography, Volume 53, Issue 4, April 2026.
ABSTRACT Aim Understanding the biodiversity and distribution patterns of microbial eukaryotes is fundamental to biosphere research. The biogeography of free‐living protists remains contentious, with the ‘everything is everywhere’ and ‘moderate endemicity’ hypotheses representing competing paradigms.
Sebastian Tarcz, Sascha Krenek, Thomas U. Berendonk, Maria Rautian, Marta Surmacz, Ewa Przyboś   +5 more
wiley   +1 more source